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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 11/2019

01-11-2019 | Cornea

Validation of corneal topographic and aberrometric measurements obtained by color light-emitting diode reflection topography in healthy eyes

Authors: David P. Piñero, Ainhoa Molina-Martín, Vicent J. Camps, Dolores de Fez, María Teresa Caballero

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2019

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Abstract

Purpose

To evaluate the intrasession repeatability of anterior corneal topographic and aberrometric measurements provided by a color-LED topographer as well as their interchangeability with those provided by a Scheimpflug-based system in healthy eyes.

Methods

Thirty-five healthy eyes of 35 patients (age, 16–66 years) were enrolled. A complete eye examination was performed in all cases including a complete corneal analysis with the Scheimpflug-based system Pentacam (Oculus Optikgeräte) (one measurement) and the Cassini system (i-Optics) (three consecutive measurements). Intrasession repeatability of the Cassini measurements was assessed with the within-subject standard deviation (Sw) and the intraclass correlation coefficient (ICC). The Bland-Altman analysis was used to evaluate the agreement between both devices.

Results

Mean Sw for keratometric readings was 0.02 mm (ICC ≥ 0.992), ranging between 0.16 and 0.05 D (ICC 0.930–0.978) for anterior and total astigmatic measurements. Mean Sw for asphericity and corneal diameter were 0.06 (ICC 0.926) and 0.03 mm (IC 0.997), respectively. Aberrometric parameters showed ICCs ≥ 0.816, except for Z42 (ICC 0.741) and Z44 (ICC 0.544). When comparing devices, statistically significant differences were found for most of topographic and aberrometric data (p ≤ 0.044). Likewise, ranges of agreement between devices were clinically relevant (keratometry > 0.06 mm; total astigmatic components > 0.69 D; asphericity 0.35; second-, third-, and fourth-order Zernike terms, more than 0.20, 0.13, and 0.01 μm, respectively).

Conclusions

Consistent anterior corneal topographic, total corneal astigmatic, and aberrometric measurements are obtained with color-LED topography in healthy eyes, which are not interchangeable with those provided by the Scheimpflug-based topography.
Literature
1.
Piñero DP (2015) Technologies for anatomical and geometric characterization of the corneal structure and anterior segment: a review. Semin Ophthalmol 30:161–170CrossRef
2.
Klijn S, Reus NJ, Sicam VADP (2015) Evaluation of keratometry with a novel color-LED corneal topographer. J Refract Surg 31:249–256CrossRef
3.
Ferreira TB, Ribeiro FJ, Kanellopoulos J, Asimellis G, Ferreira TB, Ribeiro FJ (2018) Comparability and repeatability of different methods of corneal astigmatism assessment. Clin Ophthalmol 12:29–34CrossRef
4.
Kanellopoulos J, Asimellis G (2015) Color light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas. Clin Ophthalmol 9:245–252CrossRef
5.
Hidalgo IR, Rozema JJ, Dhubhghaill SN, Zakaria N, Koppen C, Tassignon MJ (2015) Repeatability and inter-device agreement for three different methods of keratometry: Placido, Scheimpflug, and color LED corneal topography. J Refract Surg 31:176–181CrossRef
6.
Ventura BV, Al-Mohtaseb Z, Wang L, Koch DD, Weikert MP (2015) Repeatability and comparability of corneal power and corneal astigmatism obtained from a point-source color light–emitting diode topographer, a Placido-based corneal topographer, and a low-coherence reflectometer. J Cataract Refract Surg 41:2242–2250CrossRef
7.
Kanellopoulos AJ, Asimellis G (2015) Distribution and repeatability of corneal astigmatism measurements (magnitude and axis) evaluated with color light emitting diode reflection topography. Cornea 34:937–944CrossRef
8.
Hummel CD, Diakonis VF, Desai NR, Arana A, Weinstock RJ (2017) Cyclorotation during femtosecond laser–assisted cataract surgery measured using iris registration. J Cataract Refract Surg 43:952–955CrossRef
9.
Klijn S, Reus NJ, van der Sommen CM, Sicam VADP (2016) Accuracy of total corneal astigmatism measurements with a Scheimpflug imager and a color light-emitting diode corneal topographer. Am J Ophthalmol 167:72–78CrossRef
10.
Ferreira TB, Ribeiro FJ (2016) A novel color-LED corneal topographer to assess astigmatism in pseudophakic eyes. Clin Ophthalmol 10:1521–1529CrossRef
11.
Kanellopoulos AJ, Asimellis G (2013) Forme fruste keratoconus imaging and validation via novel multi-spot reflection topography. Case Rep Ophthalmol 4:199–209CrossRef
12.
Kanellopoulos AJ, Asimellis G (2014) Clinical correlation between Placido, Scheimpflug and LED color reflection topographies in imaging of a scarred cornea. Case Rep Ophthalmol 5:311–317CrossRef
13.
Piñero DP, Camps VJ, de Fez D, García C, Caballero MT (2019) Validation of posterior corneal curvature measurements obtained by color light-emitting diode reflection topography in healthy eyes. Eur J Ophthalmol (in press)
14.
Montalbán R, Piñero DP, Javaloy J, Alio JL (2013) Correlation of the corneal toricity between anterior and posterior corneal surfaces in the normal human eye. Cornea 32:791–798CrossRef
15.
Vos FM, van der Heijde GL, Spoelder HJW, van Stokkum IHM, Groen FCA (1997) A new instrument to measure the shape of the cornea based on pseudorandom color coding. IEEE Trans Instrum Meas 46:794–797CrossRef
16.
Snellenburg JJ, Braaf B, Hermans EA, van der Heijde RGL, Sicam VADP (2010) Forward ray tracing for image projection prediction and surface reconstruction in the evaluation of corneal topography systems. Opt Express 18:19324–19338CrossRef
17.
Chen D, Lam AKC (2007) Intrasession and intersession repeatability of the Pentacam system on posterior corneal assessment in the normal human eye. J Cataract Refract Surg 33:448–454CrossRef
18.
Montalbán R, Piñero DP, Javaloy J, Alió JL (2012) Intrasubject repeatability of corneal morphology measurements obtained with a new Scheimpflug photography-based system. J Cataract Refract Surg 38:971–977CrossRef
19.
Ruiz-Belda C, Rodrigo F, Piñero DP (2018) Validation of keratometric measurements obtained with an intraoperative image-guided system: intra-session repeatability and interchangeability with an optical biometer. Clin Exp Optom 101:200–205CrossRef
20.
Kumar M, Shetty R, Jayadev C, Rao HL, Dutta D (2017) Repeatability and agreement of five imaging systems for measuring anterior segment parameters in healthy eyes. Indian J Ophthalmol 65:288–294CrossRef
21.
Shetty R, Arora V, Jayadev C, Nuijts RM, Kumar M, Puttaiah NK, Kummelil MK (2014) Repeatability and agreement of three Scheimpflug-based imaging systems for measuring anterior segment parameters in keratoconus. Invest Ophthalmol Vis Sci 55:5263–5268CrossRef
22.
Mehravaran S, Asgari S, Bigdeli S, Shahnazi A, Hashemi H (2014) Keratometry with five different techniques: a study of device repeatability and inter-device agreement. Int Ophthalmol 34:869–875CrossRef
23.
Piñero DP, Camps VJ, Mateo V, Ruiz-Fortes P (2012) Clinical validation of an algorithm to correct the error in the keratometric estimation of corneal power in normal eyes. J Cataract Refract Surg 38:1333–1338CrossRef
24.
Savini G, Schiano-Lomoriello D, Hoffer KJ (2018) Repeatability of automatic measurements by a new anterior segment optical coherence tomographer combined with Placido topography and agreement with 2 Scheimpflug cameras. J Cataract Refract Surg 44:471–478CrossRef
25.
Savini G, Barboni P, Carbonelli M, Hoffer KJ (2011) Repeatability of automatic measurements by a new Scheimpflug camera combined with Placido topography. J Cataract Refract Surg 37:1809–1816CrossRef
26.
Piñero DP, López-Navarro A, Cabezos I, de Fez D, Caballero MT, Camps VJ (2017) Corneal topographic and aberrometric measurements obtained with a multidiagnostic device in healthy eyes: intrasession repeatability. J Ophthalmol 2017:2149145PubMedPubMedCentral
27.
Vinciguerra P, Camesasca FI, Calossi A (2003) Statistical analysis of physiological aberrations of the cornea. J Refract Surg 19(2 Suppl):S265–S269PubMed
28.
Shankar H, Taranath D, Santhirathelagan CT, Pesudovs K (2008) Repeatability of corneal first-surface wavefront aberrations measured with Pentacam corneal topography. J Cataract Refract Surg 34:727–734CrossRef
29.
Cerviño A, Dominguez-Vicent A, Ferrer-Blasco T, García-Lázaro S, Albarrán-Diego C (2015) Intrasubject repeatability of corneal power, thickness, and wavefront aberrations with a new version of a dual rotating Scheimpflug-Placido system. J Cataract Refract Surg 41:186–192CrossRef
30.
Wang L, Shirayama M, Koch DD (2010) Repeatability of corneal power and wavefront aberration measurements with a dual-Scheimpflug Placido corneal topographer. J Cataract Refract Surg 36:425–430CrossRef
31.
Bayhan HA, Aslan Bayhan S, Muhafiz E, Can I (2014) Repeatability of aberrometric measurements in normal and keratoconus eyes using a new Scheimpflug-Placido topographer. J Cataract Refract Surg 40:269–275CrossRef
32.
Yazdani N, Shahkarami L, OstadiMoghaddam H, Ehsaei A (2017) Topographic determination of corneal asphericity as a function of age, gender, and refractive error. Int Ophthalmol 37:807–812CrossRef
33.
Piñero DP, Caballero MT, Nicolás-Albujer JM, de Fez D, Camps VJ (2018) A new approach for the calculation of total corneal astigmatism considering the magnitude and orientation of posterior corneal astigmatism and thickness. Cornea 37:720–726CrossRef
Metadata
Title
Validation of corneal topographic and aberrometric measurements obtained by color light-emitting diode reflection topography in healthy eyes
Authors
David P. Piñero
Ainhoa Molina-Martín
Vicent J. Camps
Dolores de Fez
María Teresa Caballero
Publication date
01-11-2019
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-019-04453-5

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