Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 11/2019

01-11-2019 | Retinal Detachment | Retinal Disorders

Factors associated with macular complications in highly myopic eyes with dome-shaped macular configuration

Authors: Mumin Hocaoglu, M. Giray Ersoz, Isil Sayman Muslubas, Serra Arf, Murat Karacorlu

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 11/2019

Login to get access

Abstract

Purpose

To investigate the associations between macular complications and demographic, clinical, and optical coherence tomography characteristics (OCT) of highly myopic eyes with a dome-shaped macula (DSM).

Methods

We retrospectively analyzed the findings of 90 patients (167 eyes) with DSM who had vertical and horizontal OCT scans between January 2011 and June 2018. Demographic data, clinical characteristics, and OCT-derived morphologic parameters were determined, and the associations of these parameters with macular complications were evaluated.

Results

Among 167 eyes, the following patterns were observed: horizontally oriented DSM (71%), symmetric DSM (27%), and vertically oriented DSM (2%). Complications or abnormalities involving the macular area were detected by OCT in 63% (106/167) of the eyes. Specific complications were as follows: choroidal neovascularization (CNV) (37.1%), macular retinoschisis (9.0%), serous retinal detachment (RD) (7.8%), epiretinal membrane (4.2%), lamellar macular hole (3.0%), and macular hole (2.4%). The eyes with CNV had thinner choroid (P < 0.001) and lower macular bulge height (P = 0.04). The eyes with serous RD had thicker choroid (P < 0.001) and higher macular bulge height (P < 0.001). Serous RD was significantly more common when the macular height was greater than 250 μm (P = 0.001) and if the DSM pattern was vertical (P < 0.001).

Conclusions

A greater bulge height and thicker choroid in highly myopic eyes with DSM may be protective against the development of myopic CNV. A thicker choroid, a higher macular bulge (> 250 μm), and a vertical DSM pattern are associated with a risk of developing serous RD.
Literature
1.
Gaucher D, Erginay A, Lecleire-Collet A et al (2008) Dome-shaped macula in eyes with myopic posterior staphyloma. Am J Ophthalmol 145:909–914CrossRef
2.
Imamura Y, Iida T, Maruko I et al (2011) Enhanced depth imaging optical coherence tomography of the sclera in dome-shaped macula. Am J Ophthalmol 151:297–302CrossRef
3.
Pilotto E, Guidolin F, Parravano M et al (2018) Morphofunctional evaluation in dome-shaped macula: a microperimetry and optical coherence tomography study. Retina 38:922–930CrossRef
4.
Liang IC, Shimada N, Tanaka Y et al (2015) Comparison of clinical features in highly myopic eyes with and without a dome-shaped macula. Ophthalmology 122:1591–1600CrossRef
5.
Ceklic L, Wolf-Schnurrbusch U, Gekkieva M, Wolf S (2014) Visual acuity outcome in RADIANCE study patients with dome-shaped macular features. Ophthalmology 121:2288–2289CrossRef
6.
Ellabban AA, Tsujikawa A, Muraoka Y et al (2014) Dome-shaped macular configuration: longitudinal changes in the sclera and choroid by swept-source optical coherence tomography over two years. Am J Ophthalmol 158:1062–1070CrossRef
7.
Caillaux V, Gaucher D, Gualino V et al (2013) Morphologic characterization of dome-shaped macula in myopic eyes with serous macular detachment. Am J Ophthalmol 156:958–967CrossRef
8.
Mehdizadeh M, Nowroozzadeh MH (2008) Dome-shaped macula in eyes with myopic posterior staphyloma. Am J Ophthalmol 146:478CrossRef
9.
Fang Y, Jonas JB, Yokoi T et al (2017) Macular Bruch’s membrane defect and dome-shaped macula in high myopia. PLoS One 12:0178998
10.
Soudier G, Gaudric A, Gualino V et al (2016) Macular choroidal thickness in myopic eyes with and without a dome-shaped macula: a case-control study. Ophthalmologica 236:148–153CrossRef
11.
Ellabban AA, Tsujikawa A, Matsumoto A et al (2013) Three-dimensional tomographic features of dome-shaped macula by swept-source optical coherence tomography. Am J Ophthalmol 155:320–328CrossRef
12.
Ohsugi H, Ikuno Y, Oshima K et al (2014) Morphologic characteristics of macular complications of a dome-shaped macula determined by swept-source optical coherence tomography. Am J Ophthalmol 158:162–170CrossRef
13.
Viola F, Dell’Arti L, Benatti E et al (2015) Choroidal findings in dome-shaped macula in highly myopic eyes: a longitudinal study. Am J Ophthalmol 159:44–52CrossRef
14.
Coco RM, Sanabria MR, Alegria J (2012) Pathology associated with optical coherence tomography macular bending due to either dome-shaped macula or inferior staphyloma in myopic patients. Ophthalmologica 228:7–12CrossRef
15.
Curtin BJ (1979) Physiologic vs pathologic myopia: genetics vs environment. Ophthalmology 86:681–691CrossRef
16.
Chebil A, Ben Achour B, Chaker N et al (2014) Choroidal thickness assessment with SD-OCT in high myopia with dome-shaped macula. J Fr Ophtalmol 37:237–241CrossRef
17.
Ikuno Y, Sayanagi K, Soga K et al (2008) Lacquer crack formation and choroidal neovascularization in pathologic myopia. Retina 28:1124–1131CrossRef
18.
Ikuno Y, Jo Y, Hamasaki T, Tano Y (2010) Ocular risk factors for choroidal neovascularization in pathologic myopia. Invest Ophthalmol Vis Sci 51:3721–3725CrossRef
19.
Wakabayashi T, Ikuno Y (2010) Choroidal filling delay in choroidal neovascularisation due to pathological myopia. Br J Ophthalmol 94:611–615CrossRef
20.
Ng WY, Ting DS, Agrawal R et al (2016) Structural changes in myopic choroidal neovascularization after treatment with antivascular endothelial growth factor over 1 year. Invest Ophthalmol Vis Sci 57:4933–4939CrossRef
21.
Deobhakta A, Ross AH, Helal J Jr et al (2015) Localized choroidal thickness variation and pigment epithelial detachment in dome-shaped macula with subretinal fluid. Ophthalmic Surg Lasers Imaging Retina 46:391–392CrossRef
22.
García-Ben A, Garcia-Basterra I, González-Gómez A et al (2018) Comparison of long-term clinical evolution in highly myopic eyes with vertical oval-shaped dome with or without untreated serous retinal detachment. Br J Ophthalmol 103:385–389CrossRef
23.
Hsiang HW, Ohno-Matsui K, Shimada N et al (2008) Clinical characteristics of posterior staphyloma in eyes with pathologic myopia. Am J Ophthalmol 146:102–110CrossRef
Metadata
Title
Factors associated with macular complications in highly myopic eyes with dome-shaped macular configuration
Authors
Mumin Hocaoglu
M. Giray Ersoz
Isil Sayman Muslubas
Serra Arf
Murat Karacorlu
Publication date
01-11-2019
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 11/2019
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-019-04449-1

Other articles of this Issue 11/2019

Graefe's Archive for Clinical and Experimental Ophthalmology 11/2019 Go to the issue

Retinal Disorders

Comparison between non-visualized polyps and visualized polyps on optical coherence tomography angiography in polypoidal choroidal vasculopathy

Retinal Disorders

Predictive capacity of baseline hyperreflective dots on the intravitreal dexamethasone implant (Ozurdex®) outcomes in diabetic macular edema: a multicenter study

Glaucoma

Pseudoexfoliation syndrome: analysis of systemic comorbidities of 325 PEX-positive patients compared with 911 PEX-negative patients

Retinal Disorders

Folding the internal limiting membrane flap under perfluorocarbon liquid in large, chronic and myopic macular holes

Letter to the Editor

Letter to the editor relating to Lytvynchuk LM, Falkner-Radler CI, Krepler K, Glittenberg CG, Ahmed D et al.: “Dynamic intraoperative optical coherence tomography for inverted internal limiting membrane flap technique in large macular hole surgery” Graefes Arch Clin Exp Ophthalmol 2019 May 29; https://doi.org/10.1007/s00417-019-04364-5 [Epub ahead of print]

Basic Science

Effect of topical administration of the microneurotrophin BNN27 in the diabetic rat retina