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Open Access 01-06-2019 | Review

Magnetic resonance imaging in Alzheimer’s disease and mild cognitive impairment

Authors: Avinash Chandra, George Dervenoulas, Marios Politis, for the Alzheimer’s Disease Neuroimaging Initiative

Published in: Journal of Neurology | Issue 6/2019

Abstract

Research utilizing magnetic resonance imaging (MRI) has been crucial to the understanding of the neuropathological mechanisms behind and clinical identification of Alzheimer’s disease (AD) and mild cognitive impairment (MCI). MRI modalities show patterns of brain damage that discriminate AD from other brain illnesses and brain abnormalities that are associated with risk of conversion to AD from MCI and other behavioural outcomes. This review discusses the application of various MRI techniques to and their clinical usefulness in AD and MCI. MRI modalities covered include structural MRI, diffusion tensor imaging (DTI), arterial spin labelling (ASL), magnetic resonance spectroscopy (MRS), and functional MRI (fMRI). There is much evidence supporting the validity of MRI as a biomarker for these disorders; however, only traditional structural imaging is currently recommended for routine use in clinical settings. Future research is needed to warrant the inclusion for more advanced MRI methodology in forthcoming revisions to diagnostic criteria for AD and MCI.

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Title: Magnetic resonance imaging in Alzheimer’s disease and mild cognitive impairment
Authors: Avinash Chandra
George Dervenoulas
Marios Politis
for the Alzheimer’s Disease Neuroimaging Initiative
Publication date: 01-06-2019
Publisher: Springer Berlin Heidelberg
Published in: Journal of Neurology / Issue 6/2019
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-018-9016-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Magnetic resonance imaging in Alzheimer’s disease and mild cognitive impairment

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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