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European Radiology
Published in: European Radiology 1/2006

01-01-2006 | Neuro

FMRI of working memory in patients with mild cognitive impairment and probable Alzheimer’s disease

Authors: F. Zerrin Yetkin, Roger N. Rosenberg, Myron F. Weiner, Phillip D. Purdy, C. Munro Cullum

Published in: European Radiology | Issue 1/2006

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Abstract

The goals of this study were to evaluate brain activation in patients with probable Alzheimer’s disease (AD), mild cognitive impairment (MCI), and controls while performing a working memory (WM) task. Eleven AD patients, ten MCI subjects, and nine controls underwent functional magnetic resonance imaging (fMRI) while performing a visual WM task. Statistical parametric maps of brain activation were obtained in each group, and group activation difference maps were generated. Ability to perform the task did not differ among the groups. Activation was observed in the parahippocampal region, superior-middle-inferior frontal gyri, parietal region, anterior–posterior cingulate, fusiform gyrus, and basal ganglia. MCI and AD groups showed more activation than the controls in the right superior frontal gyrus, bilateral middle temporal, middle frontal, anterior cingulate, and fusiform gyri. Activation in the right parahippocampal gyrus, left inferior frontal gyrus, bilateral cingulate and lingual gyri, right lentiform nucleus, right fusiform gyrus, and left supramarginal gyrus in the AD group was less than in the MCI group. The WM task evoked activation in widely distributed regions, consistent with previous fMRI studies. AD and MCI patients showed an increased extent of activation and recruitment of additional areas.
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Metadata
Title
FMRI of working memory in patients with mild cognitive impairment and probable Alzheimer’s disease
Authors
F. Zerrin Yetkin
Roger N. Rosenberg
Myron F. Weiner
Phillip D. Purdy
C. Munro Cullum
Publication date
01-01-2006
Publisher
Springer-Verlag
Published in
European Radiology / Issue 1/2006
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-005-2794-x

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