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Published in: International Journal of Legal Medicine 2/2008

01-03-2008 | Original Article

Ultrasound studies on the time course of clavicular ossification

Authors: Ronald Schulz, Per Zwiesigk, Manfred Schiborr, Sven Schmidt, Andreas Schmeling

Published in: International Journal of Legal Medicine | Issue 2/2008

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Abstract

When preparing forensic age estimates for living subjects over 18 years of age, it is crucial to evaluate the stage of ossification of the medial clavicular epiphysis. The establishment of radiation-free imaging techniques for assessment of clavicular ossification would be desirable in order to reduce the radiation exposure associated with forensic age estimations. In the present study, 84 right clavicles of test subjects 12–30 years of age were prospectively evaluated by means of ultrasound. Ossification stage classification was possible in 80 of the 84 medial clavicular epiphyses studied. In the remaining cases, stage classification was not possible due to the presence of developmental anomalies. The earliest ages at which the respective ossification stages were observed were 17.1 years for stage 2, 16.7 years for stage 3, and 22.5 years for stage 4. The age intervals observed for the ossification stages are consistent with the known data from radiological and computed tomography assessments. The present study results should be confirmed in a larger number of cases and with analysis of observer variability. Evaluation of medial clavicular epiphyseal ossification by ultrasound could ultimately be a rapid and economic non-ionizing diagnostic imaging procedure for forensic age estimation.
Literature
1.
go back to reference Bilgili Y, Hizel S, Kara SA, Sanli C, Erdal HH, Altinok D (2003) Accuracy of skeletal age assessment in children from birth to 6 years of age with the ultrasonographic version of the Greulich–Pyle atlas. J Ultrasound Med 22:683–690PubMed Bilgili Y, Hizel S, Kara SA, Sanli C, Erdal HH, Altinok D (2003) Accuracy of skeletal age assessment in children from birth to 6 years of age with the ultrasonographic version of the Greulich–Pyle atlas. J Ultrasound Med 22:683–690PubMed
2.
go back to reference Braga J, Treil J (2007) Estimation of pediatric skeletal age using geometric morphometrics and three-dimensional cranial size changes. Int J Legal Med 121:439–443PubMedCrossRef Braga J, Treil J (2007) Estimation of pediatric skeletal age using geometric morphometrics and three-dimensional cranial size changes. Int J Legal Med 121:439–443PubMedCrossRef
3.
go back to reference Cameriere R, Ferrante L, Cingolani M (2006) Age estimation in children by measurement of open apices in teeth. Int J Legal Med 120:49–52PubMedCrossRef Cameriere R, Ferrante L, Cingolani M (2006) Age estimation in children by measurement of open apices in teeth. Int J Legal Med 120:49–52PubMedCrossRef
4.
go back to reference Cameriere R, Ferrante L, Mirtella D, Cingolani M (2006) Carpals and epiphyses of radius and ulna as age indicators. Int J Legal Med 120:143–146PubMedCrossRef Cameriere R, Ferrante L, Mirtella D, Cingolani M (2006) Carpals and epiphyses of radius and ulna as age indicators. Int J Legal Med 120:143–146PubMedCrossRef
5.
go back to reference Castriota-Scanderbeg A, De Micheli V (1995) Ultrasound of femoral head cartilage: a new method of assessing bone age. Skeletal Radiol 24:197–200PubMedCrossRef Castriota-Scanderbeg A, De Micheli V (1995) Ultrasound of femoral head cartilage: a new method of assessing bone age. Skeletal Radiol 24:197–200PubMedCrossRef
6.
go back to reference Castriota-Scanderbeg A, De Micheli V, Scarale MG, Bonetti MG, Cammisa M (1996) Precision of sonographic measurement of articular cartilage: inter- and intraobserver analysis. Skeletal Radiol 25:545–549PubMedCrossRef Castriota-Scanderbeg A, De Micheli V, Scarale MG, Bonetti MG, Cammisa M (1996) Precision of sonographic measurement of articular cartilage: inter- and intraobserver analysis. Skeletal Radiol 25:545–549PubMedCrossRef
7.
go back to reference Castriota-Scanderbeg A, Sacco MC, Emberti-Gialloreti L, Fraracci L (1998) Skeletal age assessment in children and young adults: comparison between a newly developed sonographic method and conventional methods. Skeletal Radiol 27:271–277PubMedCrossRef Castriota-Scanderbeg A, Sacco MC, Emberti-Gialloreti L, Fraracci L (1998) Skeletal age assessment in children and young adults: comparison between a newly developed sonographic method and conventional methods. Skeletal Radiol 27:271–277PubMedCrossRef
8.
go back to reference Giuca MR, Mazza P, Marrapese E, Cesaretti G, Calderazzi A, Carafoli D, Saggese G (2002) A comparison between radiographic and sonographic assessment of hand and wrist bones for the estimation of skeletal age in the child patient. Eur J Paediatr Dent 3:79–84PubMed Giuca MR, Mazza P, Marrapese E, Cesaretti G, Calderazzi A, Carafoli D, Saggese G (2002) A comparison between radiographic and sonographic assessment of hand and wrist bones for the estimation of skeletal age in the child patient. Eur J Paediatr Dent 3:79–84PubMed
9.
go back to reference Greulich WW, Pyle SI (1959) Radiographic atlas of skeletal development of the hand and wrist. Stanford University Press, Stanford, California Greulich WW, Pyle SI (1959) Radiographic atlas of skeletal development of the hand and wrist. Stanford University Press, Stanford, California
10.
go back to reference Kreitner K-F, Schweden F, Schild HH, Riepert T, Nafe B (1997) Die computertomographisch bestimmte Ausreifung der medialen Klavikulaepiphyse—eine additive Methode zur Altersbestimmung im Adoleszentenalter und in der dritten Lebensdekade? Fortschr Röntgenstr 166:481–486CrossRef Kreitner K-F, Schweden F, Schild HH, Riepert T, Nafe B (1997) Die computertomographisch bestimmte Ausreifung der medialen Klavikulaepiphyse—eine additive Methode zur Altersbestimmung im Adoleszentenalter und in der dritten Lebensdekade? Fortschr Röntgenstr 166:481–486CrossRef
11.
go back to reference Kreitner K-F, Schweden FJ, Riepert T, Nafe B, Thelen M (1998) Bone age determination based on the study of the medial extremity of the clavicle. Eur Radiol 8:1116–1122PubMedCrossRef Kreitner K-F, Schweden FJ, Riepert T, Nafe B, Thelen M (1998) Bone age determination based on the study of the medial extremity of the clavicle. Eur Radiol 8:1116–1122PubMedCrossRef
12.
go back to reference Lockemann U, Fuhrmann A, Püschel K, Schmeling A, Geserick G (2004) Empfehlungen für die Altersdiagnostik bei Jugendlichen und jungen Erwachsenen außerhalb des Strafverfahrens. Rechtsmedizin 14:123–125CrossRef Lockemann U, Fuhrmann A, Püschel K, Schmeling A, Geserick G (2004) Empfehlungen für die Altersdiagnostik bei Jugendlichen und jungen Erwachsenen außerhalb des Strafverfahrens. Rechtsmedizin 14:123–125CrossRef
13.
go back to reference Megremis S, Cavallo G, Michalakou M, Kehagias E, Segkos N, Agianniotakis E, Sfakianaki E (2004) Assessment of skeletal age with hand and wrist sonography: could a standardised method replace radiography? Eur Radiol 14:S514CrossRef Megremis S, Cavallo G, Michalakou M, Kehagias E, Segkos N, Agianniotakis E, Sfakianaki E (2004) Assessment of skeletal age with hand and wrist sonography: could a standardised method replace radiography? Eur Radiol 14:S514CrossRef
14.
go back to reference Mentzel HJ, Vilser C, Eulenstein M, Schwartz T, Vogt S, Bottcher J, Yaniv I, Tsoref L, Kauf E, Kaiser WA (2005) Assessment of skeletal age at the wrist in children with a new ultrasound device. Pediatr Radiol 35:429–433PubMedCrossRef Mentzel HJ, Vilser C, Eulenstein M, Schwartz T, Vogt S, Bottcher J, Yaniv I, Tsoref L, Kauf E, Kaiser WA (2005) Assessment of skeletal age at the wrist in children with a new ultrasound device. Pediatr Radiol 35:429–433PubMedCrossRef
15.
go back to reference Mentzel HJ, Vogt S, Vilser C, Schwartz T, Eulenstein M, Bottcher J, Tsoref L, Kauf E, Kaiser WA (2005) Abschätzung des Knochenalters mit einer neuen Ultraschallmethode. RoFo 177:1699–1705PubMed Mentzel HJ, Vogt S, Vilser C, Schwartz T, Eulenstein M, Bottcher J, Tsoref L, Kauf E, Kaiser WA (2005) Abschätzung des Knochenalters mit einer neuen Ultraschallmethode. RoFo 177:1699–1705PubMed
16.
go back to reference Mühler M, Schulz R, Schmidt S, Schmeling A, Reisinger W (2006) The influence of slice thickness on assessment of clavicle ossification in forensic age diagnostics. Int J Legal Med 120:15–17PubMedCrossRef Mühler M, Schulz R, Schmidt S, Schmeling A, Reisinger W (2006) The influence of slice thickness on assessment of clavicle ossification in forensic age diagnostics. Int J Legal Med 120:15–17PubMedCrossRef
17.
go back to reference Nessi R, Garattini G, Bazzini E, Zaffaroni R, Lazzerini F (1997) Ultrasonography assessment of ossification foci of the wrist and pubertal growth spurt. Radiol Med (Torino) 94:43–46 Nessi R, Garattini G, Bazzini E, Zaffaroni R, Lazzerini F (1997) Ultrasonography assessment of ossification foci of the wrist and pubertal growth spurt. Radiol Med (Torino) 94:43–46
18.
go back to reference Olze A, van Niekerk P, Ishikawa T, Zhu BL, Schulz R, Maeda H, Schmeling A (2007) Comparative study on the effect of ethnicity on wisdom tooth eruption. Int J Legal Med 121:445–448PubMedCrossRef Olze A, van Niekerk P, Ishikawa T, Zhu BL, Schulz R, Maeda H, Schmeling A (2007) Comparative study on the effect of ethnicity on wisdom tooth eruption. Int J Legal Med 121:445–448PubMedCrossRef
19.
go back to reference Owings Webb PA, Myers Suchey J (1985) Epiphyseal union of the anterior iliac crest and medial clavicle in a modern multiracial sample of American males and females. Am J Phys Anthropol 68:457–466CrossRef Owings Webb PA, Myers Suchey J (1985) Epiphyseal union of the anterior iliac crest and medial clavicle in a modern multiracial sample of American males and females. Am J Phys Anthropol 68:457–466CrossRef
20.
go back to reference Pilin A, Pudil F, Bencko V (2007) Changes in colour of different human tissues as a marker of age. Int J Legal Med 121:158–162PubMedCrossRef Pilin A, Pudil F, Bencko V (2007) Changes in colour of different human tissues as a marker of age. Int J Legal Med 121:158–162PubMedCrossRef
21.
go back to reference Schmeling A, Reisinger W, Wormanns D, Geserick G (2000) Strahlenexposition bei Röntgenuntersuchungen zur forensischen Altersschätzung Lebender. Rechtsmedizin 10:135–137CrossRef Schmeling A, Reisinger W, Wormanns D, Geserick G (2000) Strahlenexposition bei Röntgenuntersuchungen zur forensischen Altersschätzung Lebender. Rechtsmedizin 10:135–137CrossRef
22.
go back to reference Schmeling A, Kaatsch H-J, Marré B, Reisinger W, Riepert T, Ritz-Timme S, Rösing FW, Rötzscher K, Geserick G (2001) Empfehlungen für die Altersdiagnostik bei Lebenden im Strafverfahren. Rechtsmedizin 11:1–3CrossRef Schmeling A, Kaatsch H-J, Marré B, Reisinger W, Riepert T, Ritz-Timme S, Rösing FW, Rötzscher K, Geserick G (2001) Empfehlungen für die Altersdiagnostik bei Lebenden im Strafverfahren. Rechtsmedizin 11:1–3CrossRef
23.
go back to reference Schmeling A, Schulz R, Reisinger W, Mühler M, Wernecke K-D, Geserick G (2004) Studies on the time frame for ossification of medial clavicular epiphyseal cartilage in conventional radiography. Int J Legal Med 118:5–8PubMedCrossRef Schmeling A, Schulz R, Reisinger W, Mühler M, Wernecke K-D, Geserick G (2004) Studies on the time frame for ossification of medial clavicular epiphyseal cartilage in conventional radiography. Int J Legal Med 118:5–8PubMedCrossRef
24.
go back to reference Schmeling A, Baumann U, Schmidt S, Wernecke KD, Reisinger W (2006) Reference data for the Thiemann–Nitz method of assessing skeletal age for the purpose of forensic age estimation. Int J Legal Med 120:1–4PubMedCrossRef Schmeling A, Baumann U, Schmidt S, Wernecke KD, Reisinger W (2006) Reference data for the Thiemann–Nitz method of assessing skeletal age for the purpose of forensic age estimation. Int J Legal Med 120:1–4PubMedCrossRef
25.
go back to reference Schmeling A, Schulz R, Danner B, Rösing FW (2006) The impact of economic progress and modernization in medicine on the ossification of hand and wrist. Int J Legal Med 120:121–126PubMedCrossRef Schmeling A, Schulz R, Danner B, Rösing FW (2006) The impact of economic progress and modernization in medicine on the ossification of hand and wrist. Int J Legal Med 120:121–126PubMedCrossRef
26.
go back to reference Schmidt S, Koch B, Schulz R, Reisinger W, Schmeling A (2007) Comparative analysis of the applicability of the skeletal age determination methods of Greulich–Pyle and Thiemann–Nitz for forensic age estimation in living subjects. Int J Legal Med 121:293–296PubMedCrossRef Schmidt S, Koch B, Schulz R, Reisinger W, Schmeling A (2007) Comparative analysis of the applicability of the skeletal age determination methods of Greulich–Pyle and Thiemann–Nitz for forensic age estimation in living subjects. Int J Legal Med 121:293–296PubMedCrossRef
27.
go back to reference Schmidt S, Mühler M, Schmeling A, Reisinger W, Schulz R (2007) Magnetic resonance imaging of the clavicular ossification. Int J Legal Med 121:321–324PubMedCrossRef Schmidt S, Mühler M, Schmeling A, Reisinger W, Schulz R (2007) Magnetic resonance imaging of the clavicular ossification. Int J Legal Med 121:321–324PubMedCrossRef
28.
go back to reference Schulz R, Mühler M, Mutze S, Schmidt S, Reisinger W, Schmeling A (2005) Studies on the time frame for ossification of the medial epiphysis of the clavicle revealed by CT scans. Int J Legal Med 119:142–145PubMedCrossRef Schulz R, Mühler M, Mutze S, Schmidt S, Reisinger W, Schmeling A (2005) Studies on the time frame for ossification of the medial epiphysis of the clavicle revealed by CT scans. Int J Legal Med 119:142–145PubMedCrossRef
29.
go back to reference Schulze D, Rother U, Fuhrmann A, Richel S, Faulmann G, Heiland M (2006) Correlation of age and ossification of the medial clavicular epiphysis using computed tomography. Forensic Sci Int 158:184–189PubMedCrossRef Schulze D, Rother U, Fuhrmann A, Richel S, Faulmann G, Heiland M (2006) Correlation of age and ossification of the medial clavicular epiphysis using computed tomography. Forensic Sci Int 158:184–189PubMedCrossRef
30.
go back to reference Wagner UA, Diedrich V, Schmitt O (1995) Determination of skeletal maturity by ultrasound: a preliminary report. Skeletal Radiol 24:417–420PubMedCrossRef Wagner UA, Diedrich V, Schmitt O (1995) Determination of skeletal maturity by ultrasound: a preliminary report. Skeletal Radiol 24:417–420PubMedCrossRef
Metadata
Title
Ultrasound studies on the time course of clavicular ossification
Authors
Ronald Schulz
Per Zwiesigk
Manfred Schiborr
Sven Schmidt
Andreas Schmeling
Publication date
01-03-2008
Publisher
Springer-Verlag
Published in
International Journal of Legal Medicine / Issue 2/2008
Print ISSN: 0937-9827
Electronic ISSN: 1437-1596
DOI
https://doi.org/10.1007/s00414-007-0220-4

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