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European Archives of Psychiatry and Clinical Neuroscience

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Open Access 01-08-2017 | Short Communication

Repression of telomere-associated genes by microglia activation in neuropsychiatric disease

Authors: Golo Kronenberg, Ria Uhlemann, Johanna Schöner, Stephanie Wegner, Valérie Boujon, Nikolas Deigendesch, Matthias Endres, Karen Gertz

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 5/2017

Abstract

Microglia senescence may promote neuropsychiatric disease. This prompted us to examine the relationship between microglia activation states and telomere biology. A panel of candidate genes associated with telomere maintenance, mitochondrial biogenesis, and cell-cycle regulation were investigated in M1- and M2-polarized microglia in vitro as well as in MACS-purified CD11b+ microglia/brain macrophages from models of stroke, Alzheimer’s disease, and chronic stress. M1 polarization, ischemia, and Alzheimer pathology elicited a strikingly similar transcriptomic profile with, in particular, reduced expression of murine Tert. Our results link classical microglia activation with repression of telomere-associated genes, suggesting a new mechanism underlying microglia dysfunction.

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Title: Repression of telomere-associated genes by microglia activation in neuropsychiatric disease
Authors: Golo Kronenberg
Ria Uhlemann
Johanna Schöner
Stephanie Wegner
Valérie Boujon
Nikolas Deigendesch
Matthias Endres
Karen Gertz
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 5/2017
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-016-0750-1

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Repression of telomere-associated genes by microglia activation in neuropsychiatric disease

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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