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European Archives of Psychiatry and Clinical Neuroscience

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01-08-2017 | Original Paper

Impaired monocyte activation in schizophrenia: ultrastructural abnormalities and increased IL-1β production

Authors: Natalya A. Uranova, P. D. Bonartsev, L. V. Androsova, V. I. Rakhmanova, V. G. Kaleda

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 5/2017

Abstract

Monocyte activation is consistently reported in patients with schizophrenia (SZ). We aimed to study the ultrastructure of monocytes and monocyte production of IL-1β in drug-free patients with SZ and controls. Monocytes from young (18–30 y.o.) healthy and SZ men in relapse were studied. Electron microscopy and morphometry were applied to estimate areas of monocytes, volume density (Vv), areas, and number of organelles. The production IL-1β by monocytes was estimated by the ELISA method. Group differences were examined using ANCOVA. Pearson’s correlation coefficients were used to examine the effects of possible confounding variables. Correlation analyses were applied to detect the relationships between the parameters of monocytes measured and between the parameters measured and the IL-1β production. Area of nucleolus, Vv and area of mitochondria and lysosomes, and the number of lysosomes were significantly increased in patients as compared to controls. Area of mitochondria was correlated significantly with Vv and area of lysosomes, and the number of lysosomes was significantly correlated with area of monocyte and Vv of vacuoles only in the control group. The production of IL-1β by monocytes was higher in patients than in controls (p = 0.01) and was correlated with Vv of lysosomes (r = 0.68, p = 0.04) and area of lysosomes (r = 0.78, p = 0.013). The data provide new evidence for over activation of monocytes in SZ and disturbed metabolic relationships between lysosomes, mitochondria, and vacuoles.

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Title: Impaired monocyte activation in schizophrenia: ultrastructural abnormalities and increased IL-1β production
Authors: Natalya A. Uranova
P. D. Bonartsev
L. V. Androsova
V. I. Rakhmanova
V. G. Kaleda
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 5/2017
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-017-0782-1

At a glance: The STEP trials

Springer Medicine

Impaired monocyte activation in schizophrenia: ultrastructural abnormalities and increased IL-1β production

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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