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Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 4/2023

26-09-2022 | COVID-19 Vaccination | Maternal-Fetal Medicine

Covid-19 third vaccination during pregnancy: maternal and neonatal outcomes—a retrospective study

Authors: Misgav Rottenstreich, Reut Rotem, Yonit Wiener-Well, Sorina Grisaru-Granovsky, Hen Y. Sela

Published in: Archives of Gynecology and Obstetrics | Issue 4/2023

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Abstract

Purpose

To evaluate the impact of Covid-19 (Pfizer-BioNTech BNT162b2) third booster dose vaccination during pregnancy on maternal and neonatal outcomes.

Methods

This is a multicenter, retrospective computerized database study. Parturients who delivered in Israel between August and December 2021 with full records of Covid-19 disease and vaccination status were included. Those who received third booster during pregnancy were compared to those who received two doses of vaccine during pregnancy and to unvaccinated parturients. Various adverse maternal and neonatal outcomes were evaluated. Parturients who were previously positive with Covid-19 PCR swabs during pregnancy or before pregnancy were excluded. Univariate analysis was followed by multivariate analysis.

Results

A total of 2583 women were included in the analysis; 626 received the third booster dose of the BNT162b2 Covid-19 vaccine, 1094 received two doses of the vaccine, and 863 unvaccinated women. Maternal and neonatal outcomes were comparable between the study groups. An adjusted multivariable logistic regression analysis demonstrated that receiving the third booster was not associated with an increase in neither composite adverse maternal or neonatal outcome (aOR 0.9; 95% CI [0.65–1.22], p = 0.47; aOR 0.7; 95% CI [0.53–1.035], p= 0.09, respectively) when compared to those who received two doses of the vaccine. However, administration of the third booster dose during pregnancy was associated with a reduced composite adverse neonatal outcome when compared to unvaccinated women (aOR 0.6; 95% CI [0.42–0.86], p = 0.01).

Conclusion

Receiving the third booster dose of the BNT162b2 Covid-19 vaccine during pregnancy is not associated with an increased risk of any adverse maternal outcomes and may be beneficial for the neonates.
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Metadata
Title
Covid-19 third vaccination during pregnancy: maternal and neonatal outcomes—a retrospective study
Authors
Misgav Rottenstreich
Reut Rotem
Yonit Wiener-Well
Sorina Grisaru-Granovsky
Hen Y. Sela
Publication date
26-09-2022
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 4/2023
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-022-06786-9

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