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Archives of Orthopaedic and Trauma Surgery
Published in: Archives of Orthopaedic and Trauma Surgery 12/2019

01-12-2019 | Tranexamic Acid | Knee Arthroplasty

Hemostatic techniques to reduce blood transfusion after primary TKA: a meta-analysis and systematic review

Authors: Zhenyue Dong, Li Han, Yifan Song, Jianchao Qi, Fei Wang

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 12/2019

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Abstract

Purpose

To investigate the efficacy of non-tranexamic acid (TXA) on reducing blood loss and requirements of allogeneic blood transfusion (ABT) in total knee arthroplasty (TKA).

Methods

The PubMed, EMBASE, and the Cochrane Library databases were researched since incipiency to June 2018. Only randomized controlled trials (RCTs) involved with non-TXA hemostatic techniques in TKA met the inclusion criteria.

Results

A total of 36 RCTs, including 1511 patients, were recruited for analysis. The results of subgroup analysis revealed that hemostatic techniques, which could substantially decrease the rate of ABT, were cell salvage with the transfusion trigger of 9 mg/dl, fibrin sealant with a dosage of 10 ml, and postoperative flexion position.

Conclusion

The available evidence in this meta-analysis suggests that postoperative flexion position, fibrin sealant, and cell salvage can substantially decrease the rate of ABT in TKA. Further studies, including more hemostatic methods and high-quality research, are expected.
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Metadata
Title
Hemostatic techniques to reduce blood transfusion after primary TKA: a meta-analysis and systematic review
Authors
Zhenyue Dong
Li Han
Yifan Song
Jianchao Qi
Fei Wang
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Keyword
Tranexamic Acid
Published in
Archives of Orthopaedic and Trauma Surgery / Issue 12/2019
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-019-03271-y

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