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01-04-2019 | Original Contribution

Does the MIND diet decrease depression risk? A comparison with Mediterranean diet in the SUN cohort

Authors: Ujué Fresán, Maira Bes-Rastrollo, Gina Segovia-Siapco, Almudena Sanchez-Villegas, Francisca Lahortiga, Pedro-Antonio de la Rosa, Miguel-Angel Martínez-Gonzalez

Published in: European Journal of Nutrition | Issue 3/2019

Abstract

Purpose

To prospectively evaluate the association of the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) diet and the Mediterranean diet (and their components), and depression risk.

Methods

We followed-up (median 10.4 years) 15,980 adults initially free of depression at baseline or in the first 2 years of follow-up. Food consumption was measured at baseline through a validated food-frequency questionnaire, and was used to compute adherence to the MIND and the Mediterranean diets. Relationships between these two diets and incident depression were assessed through Cox regression models.

Results

We identified 666 cases of incident depression. Comparing the highest versus the lowest quartiles of adherence, we found no association of the MIND diet and incident depression. This relation was statistically significant for the Mediterranean diet {hazard ratio (HR) 0.75, [95% confidence interval (95% CI) 0.61, 0.94]; p < 0.01}, although with departure from linearity. A reduced depression risk was associated with higher consumption of both fruits and nuts [HR 0.82 (95% CI 0.69, 0.96); p = 0.02], moderate nuts consumption [HR 0.77 (95% CI 0.64, 0.93); p = 0.01], and avoidance of fast/fried food [HR 0.63 (95% CI 0.41, 0.96); p = 0.03].

Conclusions

The Mediterranean diet was associated with reduced depression risk, but we found no evidence of such an association for the MIND diet.

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Whiteford HA, Degenhardt L, Rehm J et al (2013) Global burden of disease attributable to mental and substance use disorders: findings from the global burden of disease study 2010. Lancet 382(9904):1575–1586. https://doi.org/10.1016/S0140-6736(13)61611-6 CrossRefPubMed

The Lancet (2016) Global burden of disease study 2015 assesses the state of the world’s health. http://www.thelancet.com/gbd. Accessed Apr 2017

Mykletun A, Bjerkeset O, Overland S et al (2009) Levels of anxiety and depression as predictors of mortality: the HUNT study. Br J Psychiatry 195(2):118–125. https://doi.org/10.1192/bjp.bp.108.054866 CrossRefPubMed

Casacalenda N, Perry JC, Looper K (2002) Remission in major depressive disorder: a comparison of pharmacotherapy, psychotherapy, and control conditions. Am J Psychiatry 159(8):1354–1360. https://doi.org/10.1176/appi.ajp.159.8.1354 CrossRefPubMed

van Zoonen K, Buntrock C, Ebert DD et al (2014) Preventing the onset of major depressive disorder: a meta-analytic review of psychological interventions. Int J Epidemiol 43(2):318–329. https://doi.org/10.1093/ije/dyt175 CrossRefPubMedPubMedCentral

Opie RS, Itsiopoulos C, Parletta N et al (2017) Dietary recommendations for the prevention of depression. Nutr Neurosci 20(3):161–171. https://doi.org/10.1179/1476830515Y.0000000043 CrossRefPubMed

Sanchez-Villegas A, Delgado-Rodriguez M, Alonso A et al (2009) Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. Arch Gen Psychiatry 66(10):1090–1098. https://doi.org/10.1001/archgenpsychiatry.2009.129 CrossRefPubMed

Sanchez-Villegas A, Henriquez-Sanchez P, Ruiz-Canela M et al (2015) A longitudinal analysis of diet quality scores and the risk of incident depression in the SUN Project. BMC Med 13:197. https://doi.org/10.1186/s12916-015-0428-y CrossRefPubMedPubMedCentral

Orgeta V, Qazi A, Spector A et al (2015) Psychological treatments for depression and anxiety in dementia and mild cognitive impairment: systematic review and meta-analysis. Br J Psychiatry 207(4):293–298. https://doi.org/10.1192/bjp.bp.114.148130 CrossRefPubMedPubMedCentral

10.

Richard E, Reitz C, Honig LH et al (2013) Late-life depression, mild cognitive impairment, and dementia. JAMA Neurol 70(3):374–382. https://doi.org/10.1001/jamaneurol.2013.603 CrossRefPubMedPubMedCentral

11.

Martinez-Lapiscina EH, Clavero P, Toledo E et al (2013) Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry 84(12):1318–1325. https://doi.org/10.1136/jnnp-2012-304792 CrossRefPubMed

12.

Tangney CC, Li H, Wang Y et al (2014) Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons. Neurology 83(16):1410–1416. https://doi.org/10.1212/WNL.0000000000000884 CrossRefPubMedPubMedCentral

13.

Morris MC, Evans DA, Tangney CC et al (2006) Associations of vegetable and fruit consumption with age-related cognitive change. Neurology 67(8):1370–1376. https://doi.org/10.1212/01.wnl.0000240224.38978.d8 CrossRefPubMed

14.

Devore EE, Kang JH, Breteler MM et al (2012) Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol 72(1):135–143. https://doi.org/10.1002/ana.23594 CrossRefPubMedPubMedCentral

15.

Morris MC, Tangney CC, Wang Y et al (2015) MIND diet slows cognitive decline with aging. Alzheimers Dement 11(9):1015–1022. https://doi.org/10.1016/j.jalz.2015.04.011 CrossRefPubMedPubMedCentral

16.

Morris MC, Tangney CC, Wang Y et al (2015) MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement 11(9):1007–1014. https://doi.org/10.1016/j.jalz.2014.11.009 CrossRefPubMedPubMedCentral

17.

Segui-Gomez M, de la Fuente C, Vazquez Z et al (2006) Cohort profile: the ‘Seguimiento Universidad de Navarra’ (SUN) study. Int J Epidemiol 35(6):1417–1422. https://doi.org/10.1093/ije/dyl223 CrossRefPubMed

18.

Martin-Moreno JM, Boyle P, Gorgojo L et al (1993) Development and validation of a food frequency questionnaire in Spain. Int J Epidemiol 22(3):512–519CrossRefPubMed

19.

de la Fuente-Arrillaga C, Ruiz ZV, Bes-Rastrollo M et al (2010) Reproducibility of an FFQ validated in Spain. Public Health Nutr 13(9):1364–1372. https://doi.org/10.1017/S1368980009993065 CrossRefPubMed

20.

Fernandez-Ballart JD, Pinol JL, Zazpe I et al (2010) Relative validity of a semi-quantitative food-frequency questionnaire in an elderly Mediterranean population of Spain. Br J Nutr 103(12):1808–1816. https://doi.org/10.1017/S0007114509993837 CrossRefPubMed

21.

Trichopoulou A, Costacou T, Bamia C et al (2003) Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 348(26):2599–2608. https://doi.org/10.1056/NEJMoa025039 CrossRefPubMed

22.

Schroder H, Fito M, Estruch R et al (2011) A short screener is valid for assessing Mediterranean diet adherence among older Spanish men and women. J Nutr 141(6):1140–1145. https://doi.org/10.3945/jn.110.135566 CrossRefPubMed

23.

Sanchez-Villegas A, Schlatter J, Ortuno F et al (2008) Validity of a self-reported diagnosis of depression among participants in a cohort study using the structured clinical interview for DSM-IV (SCID-I). BMC Psychiatry 8(1):43. https://doi.org/10.1186/1471-244x-8-43 CrossRefPubMedPubMedCentral

24.

Desquilbet L, Mariotti F (2010) Dose–response analyses using restricted cubic spline functions in public health research. Stat Med 29(9):1037–1057. https://doi.org/10.1002/sim.3841 CrossRefPubMed

25.

Morris MC, Tangney CC, Wang Y et al (2015) MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimer’s Dement 11(9):1007–1014. https://doi.org/10.1016/j.jalz.2014.11.009 CrossRef

26.

Smagula SF, Lotrich FE, Aizenstein HJ et al (2017) Immunological biomarkers associated with brain structure and executive function in late-life depression: exploratory pilot study. Int J Geriatr Psychiatry 32(6):692–699. https://doi.org/10.1002/gps.4512 CrossRefPubMed

27.

Pasquali MA, Harlow BL, Soares CN et al (2017) A longitudinal study of neurotrophic, oxidative, and inflammatory markers in first-onset depression in midlife women. Eur Arch Psychiatry Clin Neurosci. https://doi.org/10.1007/s00406-017-0812-z CrossRefPubMed

28.

Torres SJ, Nowson CA (2012) A moderate-sodium DASH-type diet improves mood in postmenopausal women. Nutrition 28(9):896–900. https://doi.org/10.1016/j.nut.2011.11.029 CrossRefPubMed

29.

Valipour G, Esmaillzadeh A, Azadbakht L et al (2017) Adherence to the DASH diet in relation to psychological profile of Iranian adults. Eur J Nutr 56(1):309–320. https://doi.org/10.1007/s00394-015-1081-0 CrossRefPubMed

30.

Perez-Cornago A, Sanchez-Villegas A, Bes-Rastrollo M et al. (2016) Relationship between adherence to dietary approaches to stop hypertension (DASH) diet indices and incidence of depression during up to 8 years of follow-up. Public Health Nutr:1–10. https://doi.org/10.1017/S1368980016001531

31.

Sanchez-Villegas A, Martinez-Gonzalez MA (2013) Diet, a new target to prevent depression? BMC Med 11:3. https://doi.org/10.1186/1741-7015-11-3 CrossRefPubMedPubMedCentral

32.

Mila-Villarroel R, Bach-Faig A, Puig J et al (2011) Comparison and evaluation of the reliability of indexes of adherence to the Mediterranean diet. Public Health Nutr 14(12A):2338–2345. https://doi.org/10.1017/S1368980011002606 CrossRefPubMed

33.

Bach A, Serra-Majem L, Carrasco JL et al (2006) The use of indexes evaluating the adherence to the Mediterranean diet in epidemiological studies: a review. Public Health Nutr 9(1A):132–146CrossRefPubMed

34.

Trichopoulou A, Bamia C, Trichopoulos D (2009) Anatomy of health effects of Mediterranean diet: Greek EPIC prospective cohort study. BMJ 338:b2337. https://doi.org/10.1136/bmj.b2337 CrossRefPubMedPubMedCentral

35.

Lai JS, Hiles S, Bisquera A et al (2014) A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults. Am J Clin Nutr 99(1):181–197. https://doi.org/10.3945/ajcn.113.069880 CrossRefPubMed

36.

Willett WC (2013) Nutritional epidemiology, 3rd edn. Oxford University Press, New York

Title: Does the MIND diet decrease depression risk? A comparison with Mediterranean diet in the SUN cohort
Authors: Ujué Fresán
Maira Bes-Rastrollo
Gina Segovia-Siapco
Almudena Sanchez-Villegas
Francisca Lahortiga
Pedro-Antonio de la Rosa
Miguel-Angel Martínez-Gonzalez
Publication date: 01-04-2019
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 3/2019
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-018-1653-x

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