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BMC Medicine
Published in: BMC Medicine 1/2013

Open Access 01-12-2013 | Opinion

Diet, a new target to prevent depression?

Authors: Almudena Sanchez-Villegas, Miguel A Martínez-González

Published in: BMC Medicine | Issue 1/2013

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Abstract

Background

Research on the role of diet in the prevention of depression is scarce. Some evidence suggests that depression shares common mechanisms with cardiovascular disease.

Discussion

Before considering the role of diet in the prevention of depression, several points need to be considered. First, in general, evidence has been found for the effects of isolated nutrients or foods, and not for dietary patterns. Second, most previous studies have a cross-sectional design. Third, information is generally collected though questionnaires, increasing the risk of misclassification bias. Fourth, adequate control of confounding factors in observational studies is mandatory.

Summary

Only a few cohort studies have analyzed the relationship between overall dietary patterns, such as the Mediterranean diet, and primary prevention of depression. They have found similar results to those obtained for the role of this dietary pattern in cardiovascular disease. To confirm the findings obtained in these initial cohort studies, we need further observational longitudinal studies with improved methodology, as well as large randomized primary prevention trials, with interventions based on changes in the overall food pattern, that include participants at high risk of mental disorders.
Literature
1.
Mathers CD, Lopez AD, Murray CJL: The burden of disease and mortality by condition: data, methods, and results for 2001. Global Burden of Disease and Risk Factors. Edited by: Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJL. 2006, Washington D.C.: World Bank Publications, 45-240.
2.
World Health Organization: The Global Burden of Disease 2004 Update. 2008, Geneva, Switzerland: World Health Organization
3.
Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG: Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010, 67: 220-229.CrossRefPubMed
4.
Gimeno D, Kivimaki M, Brunner EJ, Elovainio M, De Vogli R, Steptoe A, Kumari M, Lowe GD, Rumley A, Marmot MG, Ferrie JE: Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol Med. 2009, 39: 413-423.CrossRefPubMed
5.
Do DP, Dowd JB, Ranjit N, House JS, Kaplan GA: Hopelessness, depression, and early markers of endothelial dysfunction in U.S. adults. Psychosom Med. 2010, 72: 613-619.CrossRefPubMedPubMedCentral
6.
Almeida OP, McCaul K, Hankey GJ, Norman P, Jamrozik K, Flicker L: Homocysteine and depression in later life. Arch Gen Psychiatry. 2008, 65: 1286-1294.CrossRefPubMed
7.
Miura H, Ozaki N, Sawada M, Isobe K, Ohta T, Nagatsu T: A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. Stress. 2008, 11: 198-209.CrossRefPubMed
8.
Guo S, Kim WJ, Lok J, Lee SR, Besancon E, Luo BH, Stins MF, Wang X, Dedhar S, Lo EH: Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci USA. 2008, 105: 7582-7587.CrossRefPubMedPubMedCentral
9.
Bocchio-Chiavetto L, Bagnardi V, Zanardini R, Molteni R, Nielsen MG, Placentino A, Giovannini C, Rillosi L, Ventriglia M, Riva MA, Gennarelli M: Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. World J Biol Psychiatry. 2010, 11: 763-773.CrossRefPubMed
10.
Sen S, Duman R, Sanacora G: Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry. 2008, 64: 527-532.CrossRefPubMedPubMedCentral
11.
Sanchez-Villegas A, Henríquez P, Figueiras A, Ortuño F, Lahortiga F, Martínez-González MA: Long chain omega-3 fatty acids intake, fish consumption and mental disorders in the SUN cohort study. Eur J Nutr. 2007, 46: 337-346.CrossRefPubMed
12.
Sánchez-Villegas A, Verberne L, De Irala J, Ruíz-Canela M, Toledo E, Serra-Majem L, Martínez-González MA: Dietary fat intake and the risk of depression: the SUN Project. PLoS One. 2011, 6: e16268.CrossRefPubMedPubMedCentral
13.
Sánchez-Villegas A, Toledo E, de Irala J, Ruiz-Canela M, Pla-Vidal J, Martínez-González MA: Fast-food and commercial baked goods consumption and the risk of depression. Public Health Nutr. 2012, 15: 424-432.CrossRefPubMed
14.
Liu C, Xie B, Chou CP, Koprowski C, Zhou D, Palmer P, Sun P, Guo Q, Duan L, Sun X, Anderson Johnson C: Perceived stress, depression and food consumption frequency in the college students of China Seven Cities. Physiol Behav. 2007, 92: 748-754.CrossRefPubMed
15.
Sánchez-Villegas A, Delgado-Rodríguez M, Alonso A, Schlatter J, Lahortiga F, Serra Majem L, Martínez-González MA: Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. Arch Gen Psychiatry. 2009, 66: 1090-1098.CrossRefPubMed
16.
Akbaraly TN, Brunner EJ, Ferrie JE, Marmot MG, Kivimaki M, Singh-Manoux A: Dietary pattern and depressive symptoms in middle age. Br J Psychiatry. 2009, 195: 408-413.CrossRefPubMedPubMedCentral
17.
Jacka FN, Kremer PJ, Berk M, de Silva-Sanigorski AM, Moodie M, Leslie ER, Pasco JA, Swinburn BA: A prospective study of diet quality and mental health in adolescents. PLoS One. 2011, 6: e24805.CrossRefPubMedPubMedCentral
18.
Jacka FN, Mykletun A, Berk M, Bjelland I, Tell GS: The association between habitual diet quality and the common mental disorders in community-dwelling adults: the Hordaland Health study. Psychosom Med. 2011, 73: 483-490.CrossRefPubMed
19.
Jacka FN, Pasco JA, Mykletun A, Williams LJ, Hodge AM, O'Reilly SL, Nicholson GC, Kotowicz MA, Berk M: Association of Western and traditional diets with depression and anxiety in women. Am J Psychiatry. 2010, 167: 305-311.CrossRefPubMed
20.
Sánchez-Villegas A, Galbete C, Martinez-González MA, Martinez JA, Razquin C, Salas-Salvadó J, Estruch R, Buil-Cosiales P, Martí A: The effect of the Mediterranean diet on plasma brain-derived neurotrophic factor (BDNF) levels: the PREDIMED-NAVARRA randomized trial. Nutr Neurosci. 2011, 14: 195-201.CrossRefPubMed
21.
García-Toro M, Ibarra O, Gili M, Serrano MJ, Oliván B, Vicens E, Roca M: Four hygienic-dietary recommendations as add-on treatment in depression: a randomized-controlled trial. J Affect Disord. 2012, 140: 200-203.CrossRefPubMed
22.
Bloch MH, Hannestad J: Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis. Mol Psychiatry. 2012, 17: 1272-1282.CrossRefPubMed
23.
Taylor MJ, Carney SM, Goodwin GM, Geddes JR: Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. J Psychopharmacol. 2004, 18: 251-256.CrossRefPubMed
24.
Razquin C, Martinez JA, Martinez-Gonzalez MA, Fernández-Crehuet J, Santos JM, Marti A: A Mediterranean diet rich in virgin olive oil may reverse the effects of the -174G/C IL6 gene variant on 3-year body weight change. Mol Nutr Food Res. 2010, 54 (Suppl 1): 75-82.CrossRef
25.
Lairon D, Defoort C, Martin JC, Amiot-Carlin MJ, Gastaldi M, Planells R: Nutrigenetics: links between genetic background and response to Mediterranean-type diets. Public Health Nutr. 2009, 12: 1601-1606.CrossRefPubMed
26.
Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Windhauser MM, Lin PH, Karanja N: A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997, 336: 1117-1124.CrossRefPubMed
27.
Martínez-González MÁ, Corella D, Salas-Salvadó J, Ros E, Covas MI, Fiol M, Wärnberg J, Arós F, Ruíz-Gutiérrez V, Lamuela-Raventós RM, Lapetra J, Muñoz MÁ, Martínez JA, Sáez G, Serra-Majem L, Pintó X, Mitjavila MT, Tur JA, del Portillo MP, Estruch R, PREDIMED Study Investigators: Cohort profile: design and methods of the PREDIMED study. Int J Epidemiol. 2012, 41: 377-385.CrossRefPubMed
Metadata
Title
Diet, a new target to prevent depression?
Authors
Almudena Sanchez-Villegas
Miguel A Martínez-González
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2013
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/1741-7015-11-3

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