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European Journal of Nutrition
Published in: European Journal of Nutrition 3/2019

01-04-2019 | Original Contribution

Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer

Authors: Nuri El-azem, Mario Pulido-Moran, Cesar L. Ramirez-Tortosa, Jose L. Quiles, Francisca E. Cara, Pedro Sanchez-Rovira, Sergio Granados-Principal, MCarmen Ramirez-Tortosa

Published in: European Journal of Nutrition | Issue 3/2019

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Abstract

Purpose

The main objective of this study was to test the therapeutic potential of hydroxytyrosol and its combination with paclitaxel in breast cancer on oxidative stress status.

Methods

Impact on proliferation rates of different chemotherapy administration patterns was assayed in MCF-7 and MDA-MB-231 breast cancer cell lines. Breast tumor-bearing rats were randomly assigned to Control, Hydroxytyrosol, Paclitaxel and Paclitaxel plus hydroxytyrosol groups, for 6 weeks. Tumor volume, cell proliferation and several systemic oxidative stress parameters were measured. Anti-proliferative activity in vitro experiments was correlated with in vivo experiments.

Results

Combination group did significantly reduce tumor volume when compared with paclitaxel alone. Additionally, the combination improved the antioxidant status without compromising the antitumor activity of standard chemotherapy.

Conclusion

These findings reveal for the first time that hydroxytyrosol is an active partner in combined therapies with paclitaxel against breast cancer. Combination with hydroxytyrosol would also ensure a less oxidative impact of chemotherapeutic drugs that could potentially improve patient wellness.
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Metadata
Title
Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer
Authors
Nuri El-azem
Mario Pulido-Moran
Cesar L. Ramirez-Tortosa
Jose L. Quiles
Francisca E. Cara
Pedro Sanchez-Rovira
Sergio Granados-Principal
MCarmen Ramirez-Tortosa
Publication date
01-04-2019
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 3/2019
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-018-1638-9

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