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01-08-2017 | Original Contribution

Free-choice high-fat diet alters circadian oscillation of energy intake in adolescent mice: role of prefrontal cortex

Authors: Danila Del Rio, Paula Stucchi, Francisco Hernández-Nuño, Victoria Cano, Lidia Morales, Julie A. Chowen, Nuria Del Olmo, Mariano Ruiz-Gayo

Published in: European Journal of Nutrition | Issue 5/2017

Abstract

Purpose

Our aim was to characterize the effect of an unfamiliar high-fat diet (HFD) on circadian feeding behaviour, plasma parameters, body weight (BW), and gene expression in the prefrontal cortex (PFC) of adolescent male mice. To this end, mice were allowed to consume a HFD during 48 h, but one group was allowed a free choice of HFD or normal chow (FC-HFD), while the other was restricted to a non-optional unfamiliar HFD feeding (NOP-HFD).

Methods

Energy intake was monitored at 6-h intervals during 48 h. Mice cohorts were killed at 6-h intervals after 48-h dietary treatment, and PFC samples dissected for RT-PCR analysis.

Results

Mice on the FC-HFD protocol avoided eating the standard chow, showed lower energy intake and lower BW increase than NOP-HFD mice. All animals with access to HFD exhibited nocturnal overeating, but diurnal hyperphagia was more prominent in the FC-HFD cohort. A robust increase in tyrosine hydroxylase (Th) gene expression was detected specifically during the light period of the circadian cycle in FC-HFD mice. In contrast, both protocols similarly up-regulated the expression of cytosolic malic enzyme (Me1), which is very sensitive to HFD.

Conclusion

Our data show that the PFC participates in driving motivational feeding during HFD-evoked hyperphagia and also suggest that sensory neural pathways might be relevant for the onset of eating disorders and overweight. Moreover, we have observed that animals that had the possibility of choosing between standard chow and HFD were more hyperphagic and specifically displayed an overexpression of the tyrosine hydroxylase gene.

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Title: Free-choice high-fat diet alters circadian oscillation of energy intake in adolescent mice: role of prefrontal cortex
Authors: Danila Del Rio
Paula Stucchi
Francisco Hernández-Nuño
Victoria Cano
Lidia Morales
Julie A. Chowen
Nuria Del Olmo
Mariano Ruiz-Gayo
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 5/2017
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1225-x

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Free-choice high-fat diet alters circadian oscillation of energy intake in adolescent mice: role of prefrontal cortex

Abstract

Purpose

Methods

Results

Conclusion

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Abstract

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Conclusion

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