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International Journal of Colorectal Disease

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01-09-2018 | Original Article

Prognostic value of distant metastasis sites and surgery in stage IV colorectal cancer: a population-based study

Authors: Dakui Luo, Qi Liu, Wencheng Yu, Yanlei Ma, Ji Zhu, Peng Lian, Sanjun Cai, Qingguo Li, Xinxiang Li

Published in: International Journal of Colorectal Disease | Issue 9/2018

Abstract

Purpose

We investigated the prognostic value of distant metastasis sites among patients with metastatic colorectal cancer (CRC) and the significance of metastasectomy and resection of the primary CRC.

Methods

Between 2010 and 2014, patients diagnosed with metastatic colorectal adenocarcinoma were selected using the surveillance, epidemiology, and end results (SEER) database. The prognosis of these patients was compared according to the site of metastasis (liver, lung, bone, and brain). A total of 15,133 patients suffered from isolated organ involvement, while 5135 patients experienced multiple organ metastases.

Results

In the isolated organ metastasis cohort, median overall survival (OS) for patients with liver, lung, bone, and brain metastases was 16, 20, 7, and 5 months, respectively. Patients with isolated lung metastases had better cancer-specific survival (CSS) and OS as compared to patients with metastases at any other sites (p < 0.0001 for both CSS and OS). Patients with isolated liver metastases had better prognosis as compared to patients with isolated bone or brain metastases (p < 0.0001 for both CSS and OS). Moreover, patients with a single metastatic site had better prognosis than patients with multiple organs involved (p < 0.0001 for both CSS and OS). Multivariate analysis in patients with isolated organ metastases demonstrated that age ≤ 60 years, rectal cancer, being married, non-black race, N0 stage, and surgery of the primary and distant lesions showed more favorable prognosis.

Conclusions

The metastatic site was an independent prognostic factor in stage IV colorectal cancer. Also, carefully chosen patients may benefit from surgery.

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Title: Prognostic value of distant metastasis sites and surgery in stage IV colorectal cancer: a population-based study
Authors: Dakui Luo
Qi Liu
Wencheng Yu
Yanlei Ma
Ji Zhu
Peng Lian
Sanjun Cai
Qingguo Li
Xinxiang Li
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 9/2018
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-018-3091-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Prognostic value of distant metastasis sites and surgery in stage IV colorectal cancer: a population-based study

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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