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International Journal of Colorectal Disease

Published in:

01-09-2018 | Original Article

Ulcerative colitis and the aging-related development of colonic diverticula

Authors: Riccardo Nascimbeni, Silvia Casiraghi, Rosanna Cannatelli, Francesco Lanzarotto, Claudio Casella, Chiara Ricci, Vincenzo Villanacci, Nazario Portolani, Dario Moneghini

Published in: International Journal of Colorectal Disease | Issue 9/2018

Abstract

Purpose

Aim of this observational case-control study was to assess the prevalence, features, and risk factors of colonic diverticula in patients with ulcerative colitis (UC).

Methods

The data of 896 UC patients aged ≥ 30 years from Brescia IBD database were retrospectively analyzed. Individuals with colonic diverticula were identified and prevalence was compared with that of control patients undergoing screening colonoscopy after gender/age matching. A nested cohort study was then conducted among UC patients in order to define eventual association of diverticula with specific clinico-pathologic parameters.

Results

Prevalence of subjects with diverticula was 11.4% among 465 UC patients aged 49 years and older, significantly lower than 35.1% prevalence in control patients of same age and gender (p < 0.001). Advancing age was a significant risk factor for diverticula development in both groups. Among UC patients, a short duration and a late onset of UC were both significantly associated to the presence of diverticula. Moreover, UC patients with diverticula had a significantly lower frequency of flares per year, even if maximal flare severity and frequency of hospital admission were similar to those of subjects without diverticula. UC patients with diverticula had a trend toward more frequent extension of UC to the left colon, possibly because of their older age. The majority of those patients had few sigmoid diverticula without symptoms.

Conclusions

Development of colonic diverticula is substantially reduced in patients with UC, markedly among those with an early onset, a long history of inflammatory disease, and a high flare frequency. This study reinforces the hypothesis sustaining a protective role of UC against colonic diverticula.

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Title: Ulcerative colitis and the aging-related development of colonic diverticula
Authors: Riccardo Nascimbeni
Silvia Casiraghi
Rosanna Cannatelli
Francesco Lanzarotto
Claudio Casella
Chiara Ricci
Vincenzo Villanacci
Nazario Portolani
Dario Moneghini
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 9/2018
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-018-3040-8

At a glance: The STEP trials

Springer Medicine

Ulcerative colitis and the aging-related development of colonic diverticula

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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