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International Journal of Colorectal Disease

Published in:

01-09-2018 | Original Article

Clinical significance of the BRAFV600E mutation in Asian patients with colorectal cancer

Authors: Hou-Hsuan Cheng, Jen-Kou Lin, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Shih-Ching Chang

Published in: International Journal of Colorectal Disease | Issue 9/2018

Abstract

Background

To investigate the clinicopathological features and prognostic significance of the BRAFV600E mutation in Asian patients with colorectal cancer.

Methods

We retrospectively reviewed the medical records of 1969 patients with colorectal cancer admitted to Taipei Veterans General Hospital for surgical treatment between 2000 and 2013. The measured endpoint was overall survival after surgery. The prognostic value of the BRAFV600E mutation was analyzed using the log-rank test and Cox regression analysis.

Results

The BRAFV600E mutation was detected in 106 (5.4%) patients and associated with female gender, abnormal cancer antigen (CA)19-9 at diagnosis, microsatellite status, right-sided primary tumors, mucinous histology, poor differentiation, and lymphovascular invasion. Metastatic patterns were more common in non-regional lymph node metastasis (20.8 vs. 7.4%, p = 0.06) and peritoneal seeding (41. vs. 21.2%, p = 0.04). Mutations were not prognostic in the overall survival of the entire study group but only in specific patients: age < 65, normal carcinoembryonic antigen at diagnosis, and stage IV disease.

Conclusion

The BRAFV600E mutation was associated with distinct clinicopathological features and metastatic patterns. The overall survival rate was lower in selected colorectal patients with the BRAFV600E mutation.

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Title: Clinical significance of the BRAFV600E mutation in Asian patients with colorectal cancer
Authors: Hou-Hsuan Cheng
Jen-Kou Lin
Wei-Shone Chen
Jeng-Kai Jiang
Shung-Haur Yang
Shih-Ching Chang
Publication date: 01-09-2018
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 9/2018
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-018-3095-6

At a glance: The STEP trials

Springer Medicine

Clinical significance of the BRAFV600E mutation in Asian patients with colorectal cancer

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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