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Open Access 01-06-2019 | Magnetic Resonance

Technical challenges of quantitative chest MRI data analysis in a large cohort pediatric study

Authors: Anh H. Nguyen, Adria Perez-Rovira, Piotr A. Wielopolski, Juan A. Hernandez Tamames, Liesbeth Duijts, Marleen de Bruijne, Andrea Aliverti, Francesca Pennati, Tetyana Ivanovska, Harm A. W. M. Tiddens, Pierluigi Ciet

Published in: European Radiology | Issue 6/2019

Abstract

Objectives

This study was conducted in order to evaluate the effect of geometric distortion (GD) on MRI lung volume quantification and evaluate available manual, semi-automated, and fully automated methods for lung segmentation.

Methods

A phantom was scanned with MRI and CT. GD was quantified as the difference in phantom’s volume between MRI and CT, with CT as gold standard. Dice scores were used to measure overlap in shapes. Furthermore, 11 subjects from a prospective population-based cohort study each underwent four chest MRI acquisitions. The resulting 44 MRI scans with 2D and 3D Gradwarp were used to test five segmentation methods. Intraclass correlation coefficient, Bland–Altman plots, Wilcoxon, Mann–Whitney U, and paired t tests were used for statistics.

Results

Using phantoms, volume differences between CT and MRI varied according to MRI positions and 2D and 3D Gradwarp correction. With the phantom located at the isocenter, MRI overestimated the volume relative to CT by 5.56 ± 1.16 to 6.99 ± 0.22% with body and torso coils, respectively. Higher Dice scores and smaller intraobject differences were found for 3D Gradwarp MR images. In subjects, semi-automated and fully automated segmentation tools showed high agreement with manual segmentations (ICC = 0.971–0.993 for end-inspiratory scans; ICC = 0.992–0.995 for end-expiratory scans). Manual segmentation time per scan was approximately 3–4 h and 2–3 min for fully automated methods.

Conclusions

Volume overestimation of MRI due to GD can be quantified. Semi-automated and fully automated segmentation methods allow accurate, reproducible, and fast lung volume quantification. Chest MRI can be a valid radiation-free imaging modality for lung segmentation and volume quantification in large cohort studies.

Key Points

• Geometric distortion varies according to MRI setting and patient positioning.

• Automated segmentation methods allow fast and accurate lung volume quantification.

• MRI is a valid radiation-free alternative to CT for quantitative data analysis.

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Title: Technical challenges of quantitative chest MRI data analysis in a large cohort pediatric study
Authors: Anh H. Nguyen
Adria Perez-Rovira
Piotr A. Wielopolski
Juan A. Hernandez Tamames
Liesbeth Duijts
Marleen de Bruijne
Andrea Aliverti
Francesca Pennati
Tetyana Ivanovska
Harm A. W. M. Tiddens
Pierluigi Ciet
Publication date: 01-06-2019
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 6/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5863-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Technical challenges of quantitative chest MRI data analysis in a large cohort pediatric study

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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