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01-08-2012 | Urogenital

Detectability of low and intermediate or high risk prostate cancer with combined T2-weighted and diffusion-weighted MRI

Authors: Kyung Won Doo, Deuk Jae Sung, Beom Jin Park, Min Ju Kim, Sung Bum Cho, Yu Whan Oh, Young Hwii Ko, Kyung Sook Yang

Published in: European Radiology | Issue 8/2012

Abstract

Objectives

To evaluate the incremental value of diffusion-weighted imaging (DWI) in combination with T2-weighted imaging to detect low (Gleason score, ≤ 6) and intermediate or high risk (Gleason score, ≥ 7) prostate cancer.

Methods

Fifty-one patients who underwent MRI before prostatectomy were evaluated. Two readers independently scored the probability of tumour in eight regions of prostate on T2-weighted images (T2WI) and T2WI combined with apparent diffusion coefficient (ADC) maps. Data were divided into two groups—low risk and intermediate or high risk prostate cancer—and correlated with histopathological results. Diagnostic performance parameters, areas under the receiver-operating characteristic curve (AUCs) and interreader agreement were calculated.

Results

For both readers, AUCs of combined T2WI and ADC maps were greater than those of T2WI in intermediate or high risk (reader 1, 0.887 vs. 0.859; reader 2, 0.732 vs 0.662, P < 0.05) prostate cancers, but not in low risk (reader 1, 0.719 vs 0.725; reader 2, 0.685 vs. 0.680, P > 0.05) prostate cancers. Weighted κ value of combined T2WI and ADC maps was 0.689.

Conclusions

The addition of DWI to T2-weighted imaging improves the accuracy of detecting intermediate or high risk prostate cancers, but not for low risk prostate cancer detection.

Key Points

• Gleason scores influence diagnostic performance of MRI for prostate cancer detection.

• Addition of DWI does not improve low risk prostate cancer detection.

• Combined T2WI and DWI may help select intermediate or high risk patients.

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Title: Detectability of low and intermediate or high risk prostate cancer with combined T2-weighted and diffusion-weighted MRI
Authors: Kyung Won Doo
Deuk Jae Sung
Beom Jin Park
Min Ju Kim
Sung Bum Cho
Yu Whan Oh
Young Hwii Ko
Kyung Sook Yang
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: European Radiology / Issue 8/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2430-5

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Detectability of low and intermediate or high risk prostate cancer with combined T2-weighted and diffusion-weighted MRI

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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