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European Radiology

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01-02-2012 | Oncology

Prostate MRI: diffusion-weighted imaging at 1.5T correlates better with prostatectomy Gleason grades than TRUS-guided biopsies in peripheral zone tumours

Authors: Leonardo Kayat Bittencourt, Jelle O. Barentsz, Luiz Carlos Duarte de Miranda, Emerson Leandro Gasparetto

Published in: European Radiology | Issue 2/2012

Abstract

Objectives

To investigate the usefulness of Apparent Diffusion Coefficients (ADC) in predicting prostatectomy Gleason Grades (pGG) and Scores (GS), compared with ultrasound-guided biopsy Gleason Grades (bGG).

Methods

Twenty-four patients with biopsy-proven prostate cancer were included in the study. Diffusion-weighted images were obtained using 1.5-T MR with a pelvic phased-array coil. Median ADC values (b0,500,1000 s/mm²) were measured at the most suspicious areas in the peripheral zone. The relationship between ADC values and pGG or GS was assessed using Pearson’s coefficient. The relationship between bGG and pGG or GS was also evaluated. Receiver operating characteristic (ROC) curve analysis was performed to assess the performance of each method on a qualitative level.

Results

A significant negative correlation was found between mean ADCs of suspicious lesions and their pGG (r = −0.55; p < 0.01) and GS (r = −0.63; p < 0.01). No significant correlation was found between bGG and pGG (r = 0.042; p > 0.05) or GS (r = 0.048; p > 0.05). ROC analysis revealed a discriminatory performance of AUC = 0.82 for ADC and AUC = 0.46 for bGG in discerning low-grade from intermediate/high-grade lesions.

Conclusions

The ADC values of suspicious areas in the peripheral zone perform better than bGG in the correlation with prostate cancer aggressiveness, although with considerable intra-subject heterogeneity.

Key Points

• Prostate cancer aggressiveness is probably underestimated and undersampled by routine ultrasound-guided biopsies.

• Diffusion-weighted MR images show good linear correlation with prostate cancer aggressiveness.

• DWI information may be used to improve risk-assessment in prostate cancer.

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Title: Prostate MRI: diffusion-weighted imaging at 1.5T correlates better with prostatectomy Gleason grades than TRUS-guided biopsies in peripheral zone tumours
Authors: Leonardo Kayat Bittencourt
Jelle O. Barentsz
Luiz Carlos Duarte de Miranda
Emerson Leandro Gasparetto
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: European Radiology / Issue 2/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-011-2269-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prostate MRI: diffusion-weighted imaging at 1.5T correlates better with prostatectomy Gleason grades than TRUS-guided biopsies in peripheral zone tumours

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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