Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

ACC 2024 Congress

Catch up on all the top stories and latest evidence in cardiology research with our ACC 2024 Congress hub page.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 1/2011

01-01-2011 | Urogenital

Ultra-high-b-value diffusion-weighted MR imaging for the detection of prostate cancer: evaluation in 201 cases with histopathological correlation

Authors: Kazuhiro Katahira, Taro Takahara, Thomas C. Kwee, Seitaro Oda, Yasuko Suzuki, Shoji Morishita, Kosuke Kitani, Yasuyuki Hamada, Mitsuhiko Kitaoka, Yasuyuki Yamashita

Published in: European Radiology | Issue 1/2011

Login to get access

Abstract

Purpose

To assess the diagnostic performance of diffusion-weighted magnetic resonance (MR) imaging (DWI) for prostate cancer detection, using different b-values.

Methods

A total of 201 patients who underwent MR imaging before total prostatectomy were evaluated. MR images were independently assessed by three radiologists. Three combinations of sequences were separately evaluated, as follows: group 1 [T2-weighted images (T2WI) alone], group 2 (T2WI and DWI with a b-value of 1,000 s/mm2), group 3 (T2WI and DWI with a b-value of 2,000 s/mm2). Whole-mount-section histopathological examination was the reference standard. Areas under the receiver operating characteristic curve (AUCs) and diagnostic performance parameters were determined.

Results

The sensitivity, specificity, and AUC for the detection of prostate cancer were as follows: 52.2%, 80.7%, and 0.694 in group 1; 61.2%, 82.6%, and 0.755 in group 2; 73.2%, 89.7%, and 0.842 in group 3. Group 3 achieved the highest diagnostic performance, followed by group 2 (P < 0.05). In the transition zone, the specificity was lower (P < 0.001) for group 2 (82.2%) than for group 1 (86.2%).

Conclusion

The addition of diffusion-weighted images with a b-value of 2,000 s/mm2 to T2WI can improve the diagnostic performance of MR imaging in prostate cancer detection.
Literature
1.
Buckley DL, Roberts C, Parker GJM, Logue JP, Hutchnson CE (2004) Prostate cancer: evaluation of vascular characteristics with dynamic contrast-enhanced T1-weighted MR imaging-initial experience. Radiology 233:709–715CrossRefPubMed
2.
Engelbrecht MR, Huisman HF, Laheiji RJF et al (2003) Discrimination of prostate cancer from normal peripheral zone and central gland tissue by using dynamic contrast-enhanced MR imaging. Radiology 229:248–254CrossRefPubMed
3.
Turnbull LW, Buckley DL, Turnbull LS, Liney GP, Knowles AJ (1999) Differentiation of prostatic carcinoma and benign prostatic hyperplasia:correlation between dynamic Gd-DTPA-enhanced MR imaging and histopathology. J Magn Reson Imaging 9:311–316CrossRefPubMed
4.
Kim JK, Hong SS, Choi YJ et al (2005) Wash-in rate on the basis of dynamic contrast-enhanced MRI: usefulness for prostate cancer detection and localization. J Magn Reson Imaging 22:639–646CrossRefPubMed
5.
Li H, Sugimura K, Kaji Y et al (2006) Conventional MRI capabilities in the diagnosis of prostate cancer in the transition zone. AJR Am J Roentgenol 186:729–742CrossRefPubMed
6.
Lim HK, Kim JK, Kim KA, Cho KS (2009) Prostate cancer: apparent diffusion coefficient map with T2-weighted images for detection—a multireader study. Radiology 250:145–151CrossRefPubMed
7.
Tanimoto A, Nakashima J, Kohno H et al (2007) Prostate cancer screening: the clinical value of diffusion-weighted imaging and dynamic MR imaging in combination with T2-weighted imaging. J Magn Reson Imaging 25:146–152CrossRefPubMed
8.
Shimofusa R, Fujimoto H, Akamata H et al (2005) Diffusion-weighted imaging of prostate cancer. J Comput Assist Tomogr 29:149–153CrossRefPubMed
9.
Hosseinzadah K, Schwarz S (2004) Endorectal diffusion-weighted imaging in prostate cancer to differentiate malignant and benign peripheral zone tissue. J Magn Reson Imaging 20:654–661CrossRef
10.
Kim CK, Par BK, Lee HM, Kwon GY (2007) Value of diffusion-weighted imaging for the prediction of prostate cancer location at 3 T using a phased-array coil. Invest Radiol 42:842–847CrossRefPubMed
11.
Kim JH, Kim JK, Par BW, Kim N, Cho KS (2008) Apparent diffusion coefficient: prostate cancer versus noncancerous tissue according to anatomical region. J Magn Reson Imaging 28:1173–1179CrossRefPubMed
12.
Kim CK, Par BK, Han JJ, Kang TW, Lee HM (2007) Diffusion-weighted imaging of the prostate at 3 T for differentiation of malignant and benign tissue in transition and peripheral zones: preliminary results. J Comput Assist Tomogr 31:449–454CrossRefPubMed
13.
Lichy MP, Aschoff P, Plathow C et al (2007) Tumor detection by diffusion-weighted MRI and ADC-mapping- initial clinical experiences in comparison to PET-CT. Invest Radiol 42:605–613CrossRefPubMed
14.
Takahara T, Imai Y, Yamashita T, Yasuda S, Nasu S, Van Cauteren M (2004) Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med 22:275–282PubMed
15.
Ichikawa T, Erturk SM, Motosugi U et al (2006) High-b-value diffusion-weighted MRI in colorectal cancer. AJR Am J Roentgenol 187:181–184CrossRefPubMed
16.
Ichikawa T, Erturk SM, Motosugi U et al (2007) High-b-value diffusion-weighted MRI for detecting pancreatic adenocarcinoma: preliminary results. AJR Am J Roentgenol 188:409–414CrossRefPubMed
17.
Hricak H, Choyke PL, Eberhardt SC, Leibel S, Scardino PT (2007) Imaging prostate cancer: a multidisciplinary perspective. Radiology 243:28–53CrossRefPubMed
18.
Yu KK, Scheidler J, Hricak H et al (1999) Prostate cancer: prediction of extracapusular extension with endorectal MR imaging and three-dimentional proton MR spectroscopic imaging. Radiology 213:481–488PubMed
19.
Bloch BN, Furman-Haran E, Helbich TH (2007) Prostate cancer: accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging—initial results. Radiology 245:176–185CrossRefPubMed
20.
Wang L, Mullerad M, Chen H et al (2004) Prostate cancer: incremental value of endorectal MR imaging findings for prediction of extracapsular extension. Radiology 232:133–139CrossRefPubMed
21.
Sala E, Akin O, Moskowitz C et al (2006) Endorectal MR imaging in the evaluation of seminar vesicle invastion: diagnostic accuracy and multivariate feature analysis. Radiology 238:929–937CrossRefPubMed
22.
Wang L, Hricak H, Kattan M et al (2007) Prediction of seminar vesicle invasion in prostate cancer: incremental value of adding endorectal MR imaging to the Kattan nomogram. Radiology 242:182–188CrossRefPubMed
23.
Schiebler ML, Tomaszewski JE, Bezzi M et al (1989) Prostatic carcinoma and benign prostatic hyperplasia: correlation of high-resolution MR and histopathologic findings. Radiology 172:131–137PubMed
24.
Turnbull LW, Buckley DL, Turnbull LS, Liney GP, Knowles AJ (1999) Differentiation of prostatic carcinoma and benign prostatic hyperplasia: correlation between dynamic Gd-DTPA-enhanced MR imaging and histopathology. J Magn Reson Imaging 9:311–316CrossRefPubMed
25.
Kim CK, Park BK, Kim B (2010) High-b-value diffusion-weighted imaging at 3 T to detect prostate cancer: comparisons between b values of 1,000 and 2,000 s/mm2. AJR Am J Roentgenol 194:W33–W37CrossRefPubMed
26.
Roehl KA, Anterior JAV, Catalona WJ (2002) Serial biopsy results in prostate cancer screening study. J Urol 167:2435–2439CrossRefPubMed
27.
Wefer AE, Hricak H, Vigneron DB et al (2000) Sextant localization of prostate cancer: comparison of sextant biopsy, magnetic resonance imaging and magnetic resonance spectoroscopic imaging with step section histology. J Urol 164:400–404CrossRefPubMed
28.
Haider MA, van der Kwast TH, Tanguay J et al (2007) Combined T2-Weighted and diffusion-weighted MRI for Localization of prostate cancer. AJR Am J Roentgenol 189:323–328CrossRefPubMed
Metadata
Title
Ultra-high-b-value diffusion-weighted MR imaging for the detection of prostate cancer: evaluation in 201 cases with histopathological correlation
Authors
Kazuhiro Katahira
Taro Takahara
Thomas C. Kwee
Seitaro Oda
Yasuko Suzuki
Shoji Morishita
Kosuke Kitani
Yasuyuki Hamada
Mitsuhiko Kitaoka
Yasuyuki Yamashita
Publication date
01-01-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 1/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1883-7

Other articles of this Issue 1/2011

European Radiology 1/2011 Go to the issue

Musculoskeletal

Athletic injuries of the extensor carpi ulnaris subsheath: MRI findings and utility of gadolinium-enhanced fat-saturated T1-weighted sequences with wrist pronation and supination

Letter to the Editor

Diffusion-weighted MRI for detecting liver metastases: importance of the b-value

Vascular-Interventional

High-pitch dual-source CT angiography of the aortic valve-aortic root complex without ECG-synchronization

Interpretation Corner

Fibromatosis of the breast in a 52-year-old man (2010: 10b)

Magnetic Resonance

Optimal MRI methods for direct stereotactic targeting of the subthalamic nucleus and globus pallidus

Head and Neck

Tumour thickness in oral cancer using an intra-oral ultrasound probe