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Published in: European Radiology 9/2010

01-09-2010 | Hepatobiliary-Pancreas

Liver virtual non-enhanced CT with dual-source, dual-energy CT: a preliminary study

Authors: Long-Jiang Zhang, Jin Peng, Sheng-Yong Wu, Z. Jane Wang, Xin-Sheng Wu, Chang-Sheng Zhou, Xue-Man Ji, Guang-Ming Lu

Published in: European Radiology | Issue 9/2010

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Abstract

Purpose

To compare virtual non-enhanced liver CT (VNCT) from dual-energy CT (DECT) with true non-enhanced liver CT (TNCT) in patients.

Methods

A total of 102 patients underwent multi-phase abdominal CT. Liver arterial VNCT (VNCTA) and portovenous VNCT (VNCTV) images were derived from the arterial and portovenous DECT data. The mean CT number, signal to noise ratio (SNR), image quality, contrast to noise (CNR) of liver lesions, lesion detectability and radiation dose were compared.

Results

There was no difference in mean CT numbers of all organs (all P > 0.05). SNR on VNCT images was higher than that of TNCT (all P < 0.001). Image quality of VNCT was diagnostic but lower than that of TNCT (P < 0.001). VNCTA images were superior to VNCTV (P < 0.001). VNCTA and VNCTV detected 78 (91%) and 70 (81%) of 86 hepatic focal lesions visualised on TNCT. There was no difference in the size, attenuation and CNR of focal hepatic lesions (all P > 0.05), but SNR of the lesions on VNCT was higher than that on TNCT (P < 0.001). Radiation dose of biphase DECT was lower than that of routine triphase CT (P < 0.001).

Conclusion

VNCTA may potentially replace TNCT as part of a multi-phase liver imaging protocol with consequent saving in radiation dose.
Literature
1.
go back to reference Johnson TR, Krauss B, Sedlmair M, Grasruck M, Bruder H, Morhard D, Fink C, Weckbach S, Lenhard M, Schmidt B, Flohr T, Reiser MF, Becker CR (2007) Material differentiation by dual energy CT: initial experience. Eur Radiol 17:1510–1517CrossRefPubMed Johnson TR, Krauss B, Sedlmair M, Grasruck M, Bruder H, Morhard D, Fink C, Weckbach S, Lenhard M, Schmidt B, Flohr T, Reiser MF, Becker CR (2007) Material differentiation by dual energy CT: initial experience. Eur Radiol 17:1510–1517CrossRefPubMed
2.
go back to reference Zhang LJ, Zhao YE, Wu SY, Yeh BM, Zhou CS, Hu XB, Hu QJ, Lu GM (2009) Pulmonary embolism detection with dual-energy CT: experimental study of dual-source CT in rabbits. Radiology 252:61–70CrossRefPubMed Zhang LJ, Zhao YE, Wu SY, Yeh BM, Zhou CS, Hu XB, Hu QJ, Lu GM (2009) Pulmonary embolism detection with dual-energy CT: experimental study of dual-source CT in rabbits. Radiology 252:61–70CrossRefPubMed
3.
go back to reference Zhang LJ, Chai X, Wu SY, Zhao YE, Hu XB, Hu YX, Xue YB, Yang GF, Zhu H, Lu GM (2009) Detection of pulmonary embolism by dual energy CT: correlation with perfusion scintigraphy and histopathological findings in rabbits. Eur Radiol 19:2844–2854CrossRef Zhang LJ, Chai X, Wu SY, Zhao YE, Hu XB, Hu YX, Xue YB, Yang GF, Zhu H, Lu GM (2009) Detection of pulmonary embolism by dual energy CT: correlation with perfusion scintigraphy and histopathological findings in rabbits. Eur Radiol 19:2844–2854CrossRef
4.
go back to reference Ruzsics B, Lee H, Zwerner PL, Gebregziabher M, Costello P, Schoepf UJ (2008) Dual-energy CT of the heart for diagnosing coronary artery stenosis and myocardial ischemia-initial experience. Eur Radiol 18:2414–2424CrossRefPubMed Ruzsics B, Lee H, Zwerner PL, Gebregziabher M, Costello P, Schoepf UJ (2008) Dual-energy CT of the heart for diagnosing coronary artery stenosis and myocardial ischemia-initial experience. Eur Radiol 18:2414–2424CrossRefPubMed
5.
go back to reference Watanabe Y, Uotani K, Nakazawa T, Higashi M, Yamada N, Hori Y, Kanzaki S, Fukuda T, Itoh T, Naito H (2009) Dual-energy direct bone removal CT angiography for evaluation of intracranial aneurysm or stenosis: comparison with conventional digital subtraction angiography. Eur Radiol 19:1019–1024CrossRefPubMed Watanabe Y, Uotani K, Nakazawa T, Higashi M, Yamada N, Hori Y, Kanzaki S, Fukuda T, Itoh T, Naito H (2009) Dual-energy direct bone removal CT angiography for evaluation of intracranial aneurysm or stenosis: comparison with conventional digital subtraction angiography. Eur Radiol 19:1019–1024CrossRefPubMed
6.
go back to reference Boll DT, Patil NA, Paulson EK, Merkle EM, Simmons WN, Pierre SA, Preminger GM (2009) Renal stone assessment with dual-energy multidetector CT and advanced postprocessing techniques: improved characterization of renal stone composition-pilot study. Radiology 250:813–820CrossRefPubMed Boll DT, Patil NA, Paulson EK, Merkle EM, Simmons WN, Pierre SA, Preminger GM (2009) Renal stone assessment with dual-energy multidetector CT and advanced postprocessing techniques: improved characterization of renal stone composition-pilot study. Radiology 250:813–820CrossRefPubMed
7.
go back to reference Marin D, Nelson RC, Samei E, Paulson EK, Ho LM, Boll DT, DeLong DM, Yoshizumi TT, Schindera ST (2009) Hypervascular liver tumors: low tube voltage, high tube current multidetector CT during late hepatic arterial phase for detection-initial clinical experience. Radiology 251:771–779CrossRefPubMed Marin D, Nelson RC, Samei E, Paulson EK, Ho LM, Boll DT, DeLong DM, Yoshizumi TT, Schindera ST (2009) Hypervascular liver tumors: low tube voltage, high tube current multidetector CT during late hepatic arterial phase for detection-initial clinical experience. Radiology 251:771–779CrossRefPubMed
8.
go back to reference Graser A, Johnson TR, Hecht EM, Becker CR, Leidecker C, Staehler M, Stief CG, Hildebrandt H, Godoy MC, Finn ME, Stepansky F, Reiser MF, Macari M (2009) Dual-energy CT in patients suspected of having renal masses: can virtual nonenhanced images replace true nonenhanced images? Radiology 252:433–440CrossRefPubMed Graser A, Johnson TR, Hecht EM, Becker CR, Leidecker C, Staehler M, Stief CG, Hildebrandt H, Godoy MC, Finn ME, Stepansky F, Reiser MF, Macari M (2009) Dual-energy CT in patients suspected of having renal masses: can virtual nonenhanced images replace true nonenhanced images? Radiology 252:433–440CrossRefPubMed
9.
go back to reference Stolzmann P, Frauenfelder T, Pfammatter T, Peter N, Scheffel H, Lachat M, Schmidt B, Marincek B, Alkadhi H, Schertler T (2008) Endoleaks after endovascular abdominal aortic aneurysm repair: detection with dual-energy dual-source CT. Radiology 249:682–691CrossRefPubMed Stolzmann P, Frauenfelder T, Pfammatter T, Peter N, Scheffel H, Lachat M, Schmidt B, Marincek B, Alkadhi H, Schertler T (2008) Endoleaks after endovascular abdominal aortic aneurysm repair: detection with dual-energy dual-source CT. Radiology 249:682–691CrossRefPubMed
10.
go back to reference Chandarana H, Godoy MC, Vlahos I, Graser A, Babb J, Leidecker C, Macari M (2008) Abdominal aorta: evaluation with dual-source dual-energy multidetector CT after endovascular repair of aneurysms-initial observations. Radiology 249:692–700CrossRefPubMed Chandarana H, Godoy MC, Vlahos I, Graser A, Babb J, Leidecker C, Macari M (2008) Abdominal aorta: evaluation with dual-source dual-energy multidetector CT after endovascular repair of aneurysms-initial observations. Radiology 249:692–700CrossRefPubMed
11.
go back to reference Ferda J, Novák M, Mírka H, Baxa J, Ferdová E, Bednářová A, Flohr T, Schmidt B, Klotz E, Kreuzberg B (2009) The assessment of intracranial bleeding with virtual unenhanced imaging by means of dual-energy CT angiography. Eur Radiol 19:2518–2522CrossRefPubMed Ferda J, Novák M, Mírka H, Baxa J, Ferdová E, Bednářová A, Flohr T, Schmidt B, Klotz E, Kreuzberg B (2009) The assessment of intracranial bleeding with virtual unenhanced imaging by means of dual-energy CT angiography. Eur Radiol 19:2518–2522CrossRefPubMed
12.
go back to reference Behrendt FF, Schmidt B, Plumhans C, Keil S, Woodruff SG, Ackermann D, Mühlenbruch G, Flohr T, Günther RW, Mahnken AH (2009) Image fusion in dual energy computed tomography: effect on contrast enhancement, signal-to-noise ratio and image quality in computed tomography angiography. Invest Radiol 44:1–6CrossRefPubMed Behrendt FF, Schmidt B, Plumhans C, Keil S, Woodruff SG, Ackermann D, Mühlenbruch G, Flohr T, Günther RW, Mahnken AH (2009) Image fusion in dual energy computed tomography: effect on contrast enhancement, signal-to-noise ratio and image quality in computed tomography angiography. Invest Radiol 44:1–6CrossRefPubMed
13.
go back to reference Fletcher JG, Takahashi N, Hartman R, Guimaraes L, Huprich JE, Hough DM, Yu L, McCollough CH (2009) Dual-energy and dual-source CT: is there a role in the abdomen and pelvis? Radiol Clin North Am 47:41–57CrossRefPubMed Fletcher JG, Takahashi N, Hartman R, Guimaraes L, Huprich JE, Hough DM, Yu L, McCollough CH (2009) Dual-energy and dual-source CT: is there a role in the abdomen and pelvis? Radiol Clin North Am 47:41–57CrossRefPubMed
14.
go back to reference Yeh BM, Shepherd JA, Wang ZJ, Teh HS, Hartman RP, Prevrhal S (2009) Dual-energy and low-kVp CT in the abdomen. AJR Am J Roentgenol 193:47–54CrossRefPubMed Yeh BM, Shepherd JA, Wang ZJ, Teh HS, Hartman RP, Prevrhal S (2009) Dual-energy and low-kVp CT in the abdomen. AJR Am J Roentgenol 193:47–54CrossRefPubMed
15.
go back to reference Brenner DJ, Elliston CD (2004) Estimated radiation risks potentially associated with full-body CT screening. Radiology 232:735–738CrossRefPubMed Brenner DJ, Elliston CD (2004) Estimated radiation risks potentially associated with full-body CT screening. Radiology 232:735–738CrossRefPubMed
16.
go back to reference Graser A, Johnson TR, Chandarana H, Macari M (2008) Dual energy CT: preliminary observations and potential clinical applications in the abdomen. Eur Radiol 19:13–23CrossRefPubMed Graser A, Johnson TR, Chandarana H, Macari M (2008) Dual energy CT: preliminary observations and potential clinical applications in the abdomen. Eur Radiol 19:13–23CrossRefPubMed
17.
go back to reference Ma X, Samir AE, Holalkere NS, Sahani DV (2008) Optimal arterial phase imaging for detection of hypervascular hepatocellular carcinoma determined by continuous image capture on 16-MDCT. AJR Am J Roentgenol 191:772–777CrossRefPubMed Ma X, Samir AE, Holalkere NS, Sahani DV (2008) Optimal arterial phase imaging for detection of hypervascular hepatocellular carcinoma determined by continuous image capture on 16-MDCT. AJR Am J Roentgenol 191:772–777CrossRefPubMed
Metadata
Title
Liver virtual non-enhanced CT with dual-source, dual-energy CT: a preliminary study
Authors
Long-Jiang Zhang
Jin Peng
Sheng-Yong Wu
Z. Jane Wang
Xin-Sheng Wu
Chang-Sheng Zhou
Xue-Man Ji
Guang-Ming Lu
Publication date
01-09-2010
Publisher
Springer-Verlag
Published in
European Radiology / Issue 9/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1778-7

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