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European Radiology

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01-09-2010 | Magnetic Resonance

Can quantitative dynamic contrast-enhanced MRI independently characterize an ovarian mass?

Authors: Philip Dilks, Priya Narayanan, Rodney Reznek, Anju Sahdev, Andrea Rockall

Published in: European Radiology | Issue 9/2010

Abstract

Objectives

Our aim was to establish threshold criteria based on quantitative DCE-MRI data as independent predictors of malignancy in a complex (solid, solid/cystic) ovarian mass.

Methods

The MRI of 26 lesions in 25 patients with a complex ovarian mass (age range, 17–80 years; mean 43 years) was retrospectively reviewed and correlated with histology following resection. Cases with solid tumour components, definitive histology and relevant dynamic imaging were included. These were categorised into two groups, benign (N = 14) and malignant (N = 12). Following dynamic contrast-enhanced imaging, regions of interest were drawn around the solid tumour component. Maximum actual enhancement (SImax), maximum relative enhancement (SIrel), wash-in rate (WIR) and SImax (tumour)/SImax (psoas) ratio were analysed. Threshold criteria for malignancy were established.

Results

There was a significant difference in SImax (p < 0.001), SIrel (p < 0.05), WIR (p < 0.001) and SImax (tumour)/SImax (psoas) between the two groups. Optimal threshold criteria for malignancy were established; SImax ≥ 250 or SImax (tumour)/SImax (psoas) ≥ 2.35 divided the two groups with 100% sensitivity, specificity and accuracy.

Conclusion

Threshold criteria established in this preliminary study using quantitative DCE-MRI provide an accurate method for the prediction of malignancy, particularly in preoperative indeterminate cases.

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Title: Can quantitative dynamic contrast-enhanced MRI independently characterize an ovarian mass?
Authors: Philip Dilks
Priya Narayanan
Rodney Reznek
Anju Sahdev
Andrea Rockall
Publication date: 01-09-2010
Publisher: Springer-Verlag
Published in: European Radiology / Issue 9/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-010-1795-6

2024 ASCO Annual Meeting

Springer Medicine

Can quantitative dynamic contrast-enhanced MRI independently characterize an ovarian mass?

Abstract

Objectives

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

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