Skip to main content
Top
Published in: Rheumatology International 10/2020

01-10-2020 | Fibromyalgia | Review

The effectiveness and safety of electrotherapy in the management of fibromyalgia

Author: Ilke Coskun Benlidayi

Published in: Rheumatology International | Issue 10/2020

Login to get access

Abstract

Treating fibromyalgia is a challenging task for physicians. With its multifaceted features, fibromyalgia requires a comprehensive management strategy focusing on both the pharmacological and non-pharmacological treatment options. During the last decades, there has been growing evidence regarding the role of electrotherapy in fibromyalgia treatment. In this regard, the present article aimed to review the recent literature on the effectiveness and safety of the electrotherapy in the treatment of fibromyalgia. A literature search was conducted through PubMed/MEDLINE and Scopus databases. Transcutaneous electrical nerve stimulation (TENS), non-invasive brain stimulation (transcranial direct current/magnetic stimulation), and light amplification by stimulated emission of radiation (LASER) emerged as the most commonly examined electrotherapy techniques in fibromyalgia. Currently, there is growing data regarding the effectiveness of electrotherapy in the management of fibromyalgia-related pain. Besides, non-invasive electrotherapy techniques are related to no/minor side effects. Further studies are warranted to identify the optimal treatment protocols for each electrotherapy modality.
Literature
7.
go back to reference Castillo-Saavedra L, Gebodh N, Bikson M, Diaz-Cruz C, Brandao R, Coutinho L, Truong D, Datta A, Shani-Hershkovich R, Weiss M, Laufer I, Reches A, Peremen Z, Geva A, Parra LC, Fregni F (2016) Clinically effective treatment of fibromyalgia pain with high-definition transcranial direct current stimulation: phase ii open-label dose optimization. J Pain 17:14–26. https://doi.org/10.1016/j.jpain.2015.09.009CrossRefPubMed Castillo-Saavedra L, Gebodh N, Bikson M, Diaz-Cruz C, Brandao R, Coutinho L, Truong D, Datta A, Shani-Hershkovich R, Weiss M, Laufer I, Reches A, Peremen Z, Geva A, Parra LC, Fregni F (2016) Clinically effective treatment of fibromyalgia pain with high-definition transcranial direct current stimulation: phase ii open-label dose optimization. J Pain 17:14–26. https://​doi.​org/​10.​1016/​j.​jpain.​2015.​09.​009CrossRefPubMed
9.
go back to reference Vayvay ES, Tok D, Turgut E, Tunay VB (2016) The effect of Laser and taping on pain, functional status and quality of life in patients with fibromyalgia syndrome: a placebo-randomized controlled clinical trial. J Back Musculoskelet Rehabil 29:77–83CrossRef Vayvay ES, Tok D, Turgut E, Tunay VB (2016) The effect of Laser and taping on pain, functional status and quality of life in patients with fibromyalgia syndrome: a placebo-randomized controlled clinical trial. J Back Musculoskelet Rehabil 29:77–83CrossRef
12.
17.
go back to reference Sherry JE, Oehrlein KM, Hegge KS, Morgan BJ (2001) Effect of burst-mode transcutaneous electrical nerve stimulation on peripheral vascular resistance. Phys Ther 81:1183–1191CrossRef Sherry JE, Oehrlein KM, Hegge KS, Morgan BJ (2001) Effect of burst-mode transcutaneous electrical nerve stimulation on peripheral vascular resistance. Phys Ther 81:1183–1191CrossRef
19.
go back to reference Carbonario F, Matsutani LA, Yuan SL, Marques AP (2013) Effectiveness of high-frequency transcutaneous electrical nerve stimulation at tender points as adjuvant therapy for patients with fibromyalgia. Eur J Phys Rehabil Med 49:197–204PubMed Carbonario F, Matsutani LA, Yuan SL, Marques AP (2013) Effectiveness of high-frequency transcutaneous electrical nerve stimulation at tender points as adjuvant therapy for patients with fibromyalgia. Eur J Phys Rehabil Med 49:197–204PubMed
22.
go back to reference Scaturro D, Guggino G, Tumminelli LG, Ciccia F, Letizia Mauro G (2019) An intense physical rehabilitation programme determines pain relief and improves the global quality of life in patients with fibromyalgia. Clin Exp Rheumatol 37:670–675PubMed Scaturro D, Guggino G, Tumminelli LG, Ciccia F, Letizia Mauro G (2019) An intense physical rehabilitation programme determines pain relief and improves the global quality of life in patients with fibromyalgia. Clin Exp Rheumatol 37:670–675PubMed
28.
go back to reference Guinot M, Maindet C, Hodaj H, Hodaj E, Bachasson D, Baillieul S, Cracowski JL, Launois S (2019) Effects of repetitive transcranial magnetic stimulation and multicomponent therapy in patients with fibromyalgia: a randomized controlled trial. Arthr Care Res (Hoboken) https://doi.org/10.1002/acr.24118 (Epub ahead of print)CrossRef Guinot M, Maindet C, Hodaj H, Hodaj E, Bachasson D, Baillieul S, Cracowski JL, Launois S (2019) Effects of repetitive transcranial magnetic stimulation and multicomponent therapy in patients with fibromyalgia: a randomized controlled trial. Arthr Care Res (Hoboken) https://​doi.​org/​10.​1002/​acr.​24118 (Epub ahead of print)CrossRef
30.
go back to reference Foerster BR, Nascimento TD, DeBoer M, Bender MA, Rice IC, Truong DQ, Bikson M, Clauw DJ, Zubieta JK, Harris RE, DaSilva AF (2015) Excitatory and inhibitory brain metabolites as targets of motor cortex transcranial direct current stimulation therapy and predictors of its efficacy in fibromyalgia. Arthritis Rheumatol 67:576–581CrossRef Foerster BR, Nascimento TD, DeBoer M, Bender MA, Rice IC, Truong DQ, Bikson M, Clauw DJ, Zubieta JK, Harris RE, DaSilva AF (2015) Excitatory and inhibitory brain metabolites as targets of motor cortex transcranial direct current stimulation therapy and predictors of its efficacy in fibromyalgia. Arthritis Rheumatol 67:576–581CrossRef
33.
36.
go back to reference Khedr EM, Omran EAH, Ismail NM, El-Hammady DH, Goma SH, Kotb H, Galal H, Osman AM, Farghaly HSM, Karim AA, Ahmed GA (2017) Effects of transcranial direct current stimulation on pain, mood and serum endorphin level in the treatment of fibromyalgia: a double blinded, randomized clinical trial. Brain Stimul 10:893–901. https://doi.org/10.1016/j.brs.2017.06.006CrossRefPubMed Khedr EM, Omran EAH, Ismail NM, El-Hammady DH, Goma SH, Kotb H, Galal H, Osman AM, Farghaly HSM, Karim AA, Ahmed GA (2017) Effects of transcranial direct current stimulation on pain, mood and serum endorphin level in the treatment of fibromyalgia: a double blinded, randomized clinical trial. Brain Stimul 10:893–901. https://​doi.​org/​10.​1016/​j.​brs.​2017.​06.​006CrossRefPubMed
37.
go back to reference Villamar MF, Wivatvongvana P, Patumanond J, Bikson M, Truong DQ, Datta A, Fregni F (2013) Focal modulation of the primary motor cortex in fibromyalgia using 4×1-ring high-definition transcranial direct current stimulation (HD-tDCS): immediate and delayed analgesic effects of cathodal and anodal stimulation. J Pain 14:371–383. https://doi.org/10.1016/j.jpain.2012.12.007CrossRefPubMed Villamar MF, Wivatvongvana P, Patumanond J, Bikson M, Truong DQ, Datta A, Fregni F (2013) Focal modulation of the primary motor cortex in fibromyalgia using 4×1-ring high-definition transcranial direct current stimulation (HD-tDCS): immediate and delayed analgesic effects of cathodal and anodal stimulation. J Pain 14:371–383. https://​doi.​org/​10.​1016/​j.​jpain.​2012.​12.​007CrossRefPubMed
40.
41.
go back to reference Carvalho F, Brietzke AP, Gasparin A, Dos Santos FP, Vercelino R, Ballester RF, Sanches PRS, da Silva DP, Torres ILS, Fregni F, Caumo W (2018) Home-based transcranial direct current stimulation device development: an updated protocol used at home in healthy subjects and fibromyalgia patients. J Vis Exp https://doi.org/10.3791/57614(137)CrossRefPubMedPubMedCentral Carvalho F, Brietzke AP, Gasparin A, Dos Santos FP, Vercelino R, Ballester RF, Sanches PRS, da Silva DP, Torres ILS, Fregni F, Caumo W (2018) Home-based transcranial direct current stimulation device development: an updated protocol used at home in healthy subjects and fibromyalgia patients. J Vis Exp https://​doi.​org/​10.​3791/​57614(137)CrossRefPubMedPubMedCentral
42.
go back to reference Berlim MT, Van den Eynde F, Jeff Daskalakis Z (2013) Clinically meaningful efficacy and acceptability of low-frequency repetitive transcranial magnetic stimulation (rTMS) for treating primary major depression: a meta-analysis of randomized, double-blind and sham-controlled trials. Neuropsychopharmacology 38:543–551. https://doi.org/10.1038/npp.2012.237CrossRefPubMed Berlim MT, Van den Eynde F, Jeff Daskalakis Z (2013) Clinically meaningful efficacy and acceptability of low-frequency repetitive transcranial magnetic stimulation (rTMS) for treating primary major depression: a meta-analysis of randomized, double-blind and sham-controlled trials. Neuropsychopharmacology 38:543–551. https://​doi.​org/​10.​1038/​npp.​2012.​237CrossRefPubMed
44.
go back to reference Tekin A, Ozdil E, Güleken MD, Iliser R, Bakim B, Oncu J, Cevik M, Kuran B (2014) Efficacy of high frequency [10 Hz] repetitive transcranial magnetic stimulation of the primary motor cortex in patients with fibromyalgia syndrome: a randomized double blind, sham-controlled trial. J Musculoskelet Pain 22:20–26. https://doi.org/10.3109/10582452.2014.883042CrossRef Tekin A, Ozdil E, Güleken MD, Iliser R, Bakim B, Oncu J, Cevik M, Kuran B (2014) Efficacy of high frequency [10 Hz] repetitive transcranial magnetic stimulation of the primary motor cortex in patients with fibromyalgia syndrome: a randomized double blind, sham-controlled trial. J Musculoskelet Pain 22:20–26. https://​doi.​org/​10.​3109/​10582452.​2014.​883042CrossRef
45.
go back to reference Abd Elghany SE, Al Ashkar DS, El-Barbary AM, El Khouly RM, Aboelhawa MA, Nada DW, Darwish NF, Hussein MS, Rageh ES, Abo-Zaid MH, Eldesoky IF, Afifi S (2019) Regenerative injection therapy and repetitive transcranial magnetic stimulation in primary fibromyalgia treatment: a comparative study. J Back Musculoskelet Rehabil 32:55–62. https://doi.org/10.3233/BMR-181127CrossRefPubMed Abd Elghany SE, Al Ashkar DS, El-Barbary AM, El Khouly RM, Aboelhawa MA, Nada DW, Darwish NF, Hussein MS, Rageh ES, Abo-Zaid MH, Eldesoky IF, Afifi S (2019) Regenerative injection therapy and repetitive transcranial magnetic stimulation in primary fibromyalgia treatment: a comparative study. J Back Musculoskelet Rehabil 32:55–62. https://​doi.​org/​10.​3233/​BMR-181127CrossRefPubMed
46.
go back to reference Fitzgibbon BM, Hoy KE, Knox LA, Guymer EK, Littlejohn G, Elliot D, Wambeek LE, McQueen S, Elford KA, Lee SJ, Enticott PG, Fitzgerald PB (2018) Evidence for the improvement of fatigue in fibromyalgia: a 4-week left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation randomized-controlled trial. Eur J Pain 22:1255–1267. https://doi.org/10.1002/ejp.1213CrossRefPubMed Fitzgibbon BM, Hoy KE, Knox LA, Guymer EK, Littlejohn G, Elliot D, Wambeek LE, McQueen S, Elford KA, Lee SJ, Enticott PG, Fitzgerald PB (2018) Evidence for the improvement of fatigue in fibromyalgia: a 4-week left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation randomized-controlled trial. Eur J Pain 22:1255–1267. https://​doi.​org/​10.​1002/​ejp.​1213CrossRefPubMed
49.
go back to reference Maestú C, Blanco M, Nevado A, Romero J, Rodríguez-Rubio P, Galindo J, Bautista Lorite J, de las Morenas F, Fernández-Argüelles P (2013) Reduction of pain thresholds in fibromyalgia after very low-intensity magnetic stimulation: a double-blinded, randomized placebo-controlled clinical trial. Pain Res Manag 18:e101–e106CrossRef Maestú C, Blanco M, Nevado A, Romero J, Rodríguez-Rubio P, Galindo J, Bautista Lorite J, de las Morenas F, Fernández-Argüelles P (2013) Reduction of pain thresholds in fibromyalgia after very low-intensity magnetic stimulation: a double-blinded, randomized placebo-controlled clinical trial. Pain Res Manag 18:e101–e106CrossRef
51.
go back to reference Germano Maciel D, Trajano da Silva M, Rodrigues JA, Viana Neto JB, de França IM, Melo ABM, Barros da Silva TYP, de Brito Vieira WH (2018) Low-level laser therapy combined to functional exercise on treatment of fibromyalgia: a double-blind randomized clinical trial. Lasers Med Sci 33:1949–1959. https://doi.org/10.1007/s10103-018-2561-2CrossRefPubMed Germano Maciel D, Trajano da Silva M, Rodrigues JA, Viana Neto JB, de França IM, Melo ABM, Barros da Silva TYP, de Brito Vieira WH (2018) Low-level laser therapy combined to functional exercise on treatment of fibromyalgia: a double-blind randomized clinical trial. Lasers Med Sci 33:1949–1959. https://​doi.​org/​10.​1007/​s10103-018-2561-2CrossRefPubMed
53.
go back to reference Molina-Torres G, Rodríguez-Archilla A, Matarán-Peñarrocha G, Albornoz-Cabello M, Aguilar-Ferrándiz ME, Castro-Sánchez AM (2016) Laser therapy and occlusal stabilization splint for temporomandibular disorders in patients with fibromyalgia syndrome: a randomized, clinical trial. Altern Ther Health Med 22:23–31PubMed Molina-Torres G, Rodríguez-Archilla A, Matarán-Peñarrocha G, Albornoz-Cabello M, Aguilar-Ferrándiz ME, Castro-Sánchez AM (2016) Laser therapy and occlusal stabilization splint for temporomandibular disorders in patients with fibromyalgia syndrome: a randomized, clinical trial. Altern Ther Health Med 22:23–31PubMed
58.
go back to reference da Silva MM, Albertini R, de Tarso Camillo, de Carvalho P, Leal-Junior ECP, Bussadori SK, Vieira SS, Bocalini DS, de Oliveira LVF, Grandinetti V, Silva JA Jr, Serra AJ (2018) Randomized, blinded, controlled trial on effectiveness of photobiomodulation therapy and exercise training in the fibromyalgia treatment. Lasers Med Sci 33:343–351. https://doi.org/10.1007/s10103-017-2388-2CrossRefPubMed da Silva MM, Albertini R, de Tarso Camillo, de Carvalho P, Leal-Junior ECP, Bussadori SK, Vieira SS, Bocalini DS, de Oliveira LVF, Grandinetti V, Silva JA Jr, Serra AJ (2018) Randomized, blinded, controlled trial on effectiveness of photobiomodulation therapy and exercise training in the fibromyalgia treatment. Lasers Med Sci 33:343–351. https://​doi.​org/​10.​1007/​s10103-017-2388-2CrossRefPubMed
59.
go back to reference de Souza RC, de Sousa ET, Scudine KG, Meira UM, de Oliveira E, Silva EM, Gomes AC, Limeira-Junior FA (2018) Low-level laser therapy and anesthetic infiltration for orofacial pain in patients with fibromyalgia: a randomized clinical trial. Med Oral Patol Oral Cir Bucal 23:e65–e71. https://doi.org/10.4317/medoral.21965CrossRefPubMed de Souza RC, de Sousa ET, Scudine KG, Meira UM, de Oliveira E, Silva EM, Gomes AC, Limeira-Junior FA (2018) Low-level laser therapy and anesthetic infiltration for orofacial pain in patients with fibromyalgia: a randomized clinical trial. Med Oral Patol Oral Cir Bucal 23:e65–e71. https://​doi.​org/​10.​4317/​medoral.​21965CrossRefPubMed
66.
go back to reference Thieme K, Meller T, Evermann U, Malinowski R, Mathys MG, Graceley RH, Maixner W, Turk DC (2019) Efficacy of systolic extinction training in fibromyalgia patients with elevated blood pressure response to stress: a tailored randomized controlled trial. Arthr Care Res (Hoboken) 71:678–688. https://doi.org/10.1002/acr.23615CrossRef Thieme K, Meller T, Evermann U, Malinowski R, Mathys MG, Graceley RH, Maixner W, Turk DC (2019) Efficacy of systolic extinction training in fibromyalgia patients with elevated blood pressure response to stress: a tailored randomized controlled trial. Arthr Care Res (Hoboken) 71:678–688. https://​doi.​org/​10.​1002/​acr.​23615CrossRef
Metadata
Title
The effectiveness and safety of electrotherapy in the management of fibromyalgia
Author
Ilke Coskun Benlidayi
Publication date
01-10-2020
Publisher
Springer Berlin Heidelberg
Published in
Rheumatology International / Issue 10/2020
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-020-04618-0

Other articles of this Issue 10/2020

Rheumatology International 10/2020 Go to the issue