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01-09-2016 | Introduction

Basophils and mast cells in immunity and inflammation

Authors: Yoshinori Yamanishi, Hajime Karasuyama

Published in: Seminars in Immunopathology | Issue 5/2016

Excerpt

Basophils and mast cells were originally described, by Paul Ehrlich more than 130 years ago, as characteristic cells showing metachromatic stain with basic aniline dyes. They were long thought to be associated with allergic inflammation and parasitic infection, because their accumulation was frequently observed at inflamed sites of these diseases. However, the functional significance of these cells in vivo, particularly basophils, remained ill-defined compared with other immune cells such as T and B cells. …

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Title: Basophils and mast cells in immunity and inflammation
Authors: Yoshinori Yamanishi
Hajime Karasuyama
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Seminars in Immunopathology / Issue 5/2016
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-016-0582-0

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Other articles of this Issue 5/2016

Regulatory roles of mast cells in immune responses

Role of basophils in protective immunity to parasitic infections

Basophil-derived IL-4 plays versatile roles in immunity

Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells

Roles of basophils and mast cells in cutaneous inflammation

New insights into basophil heterogeneity

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