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Seminars in Immunopathology
Published in: Seminars in Immunopathology 5/2016

01-09-2016 | Review

Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells

Authors: Shih Han Tsai, Kiyoshi Takeda

Published in: Seminars in Immunopathology | Issue 5/2016

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Abstract

Adenosine 5′-triphosphate (ATP) is released from dying or damaged cells, as well as from activated cells. Once secreted, extracellular ATP induces several immune responses via P2X and P2Y receptors. Basophils and mast cells release ATP upon FcεRI-crosslinking, and ATP activates basophils and mast cells in an autocrine manner. Nucleotide-converting ectoenzymes, such as E-NTPD1, E-NTPD7, and E-NPP3, inhibit ATP-dependent immune responses by hydrolyzing ATP, thereby contributing to immune response regulation. E-NPP3 is a well-known activation marker for human basophils. E-NPP3’s physiologic function has recently been disclosed in mice. E-NPP3 is rapidly induced on basophils and mast cells after FcεRI-crosslinking and hydrolyzes extracellular ATP on cell surfaces to prevent ATP-dependent excess activation of basophils and mast cells. In the absence of E-NPP3, basophils and mast cells are overactivated and mice suffer from severe chronic allergic inflammation. Thus, the ATP-hydrolyzing ectoenzymes E-NPP3 has a nonnegligible role in the regulation of basophil- and mast cell-mediated allergic responses.
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Metadata
Title
Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells
Authors
Shih Han Tsai
Kiyoshi Takeda
Publication date
01-09-2016
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 5/2016
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-016-0564-2

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