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Published in: Seminars in Immunopathology 5/2013

01-09-2013 | Review

Monocyte heterogeneity in cardiovascular disease

Authors: Peter Libby, Matthias Nahrendorf, Filip K. Swirski

Published in: Seminars in Immunopathology | Issue 5/2013

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Abstract

Only a few decades ago, students of the pathophysiology of cardiovascular disease paid little heed to the involvement of inflammation and immunity. Multiple lines of evidence now point to the participation of innate and adaptive immunity and inflammatory signaling in a variety of cardiovascular conditions. Hence, interest has burgeoned in this intersection. This review will focus on the contribution of innate immunity to both acute injury to the heart muscle itself, notably myocardial infarction, and to chronic inflammation in the artery wall, namely atherosclerosis, the cause of most myocardial infarctions. Our discussion of the operation of innate immunity in cardiovascular diseases will focus on functions of the mononuclear phagocytes, with special attention to emerging data regarding the participation of different functional subsets of these cells in cardiovascular pathophysiology.
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Metadata
Title
Monocyte heterogeneity in cardiovascular disease
Authors
Peter Libby
Matthias Nahrendorf
Filip K. Swirski
Publication date
01-09-2013
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 5/2013
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-013-0387-3

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