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Published in: Seminars in Immunopathology 5/2013

01-09-2013 | Review

Macrophage heterogeneity in lymphoid tissues

Authors: Joke M. M. den Haan, Luisa Martinez-Pomares

Published in: Seminars in Immunopathology | Issue 5/2013

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Abstract

Macrophages in lymphoid organs exhibit a wide variety of phenotypes and functions. These cells excel in the removal of apoptotic cells that arise during the generation of immune cells and are thereby essential for the prevention of auto-immune responses. In addition to this macrophages in the secondary lymphoid organs form an important barrier for spreading of infections by phagocytosis of pathogens and the activation of both innate and adaptive immune responses. Thus, the remarkable ability of macrophages to phagocytose and handle a wide range of self and non-self material and to produce immunomediators is effectively exploited within lymphoid organs to regulate immune activation.
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Metadata
Title
Macrophage heterogeneity in lymphoid tissues
Authors
Joke M. M. den Haan
Luisa Martinez-Pomares
Publication date
01-09-2013
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 5/2013
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-013-0378-4

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