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Open Access 01-06-2021 | Graft-Versus-Host Disease | Review Article

What is known about palliative care in adult patients with allogeneic stem cell transplantation (allo-SCT)?

Authors: Steffen T. Simon, Anne Pralong, Michael Hallek, Christoph Scheid, Udo Holtick, Marco Herling

Published in: Annals of Hematology | Issue 6/2021

Abstract

Patients undergoing allogeneic stem cell transplantation (allo-SCT) are given a real chance of cure, but at the same time are confronted with a considerable risk of mortality and of severe long-term impediments. This narrative, non-systematic literature review aims to describe the supportive and palliative care needs of allo-SCT recipients, including long-term survivors or those relapsing or dying after transplantation. It also evaluates the feasibility and effectivity of integrating palliative care early in transplant procedures. In this appraisal of available literature, the main findings relate to symptoms like fatigue and psychological distress, which appear to be very common in the whole allo-SCT trajectory and might even persist many years post-transplantation. Chronic GvHD has a major negative impact on quality of life. Overall, there is a paucity of research on further issues in the context of allo-SCT, like the distress related to the frequently unpredictable post-transplant trajectory and prognosis, as well as the end-of-life phase. First randomized controlled results support the effectiveness of early integration of specialized palliative care expertise into transplant algorithms. Barriers to this implementation are discussed.

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Title: What is known about palliative care in adult patients with allogeneic stem cell transplantation (allo-SCT)?
Authors: Steffen T. Simon
Anne Pralong
Michael Hallek
Christoph Scheid
Udo Holtick
Marco Herling
Publication date: 01-06-2021
Publisher: Springer Berlin Heidelberg
Keywords: Graft-Versus-Host Disease
Care
Graft-Versus-Host Disease
Anxiety
Fatigue
Stem Cell Transplantation
Stem Cell Transplantion
Stem Cell Transplantation
Published in: Annals of Hematology / Issue 6/2021
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-021-04538-4

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What is known about palliative care in adult patients with allogeneic stem cell transplantation (allo-SCT)?

Abstract

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