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01-07-2020 | Eosinophilia | Original Article

A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction

Authors: Zhao Cheng, Yunya Luo, Yang Zhang, Yewei Wang, Yi Chen, Yunxiao Xu, Honling Peng, Guangsen Zhang

Published in: Annals of Hematology | Issue 7/2020

Abstract

NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (NUTM1) fuses to bromodomain protein family member 4 gene (BRD4), resulting in the formation of BRD4-NUTM1 transcript. Here, we report a case with myeloid neoplasm complicating with eosinophilia (MLN-Eo) and rearrangement of PDGFRA, which co-exists with a new nucleosome assemble protein 1–like 4 gene (NAP1L4) NAP1L4-NUTM1 fusion. The patient have unusually clinical features and therapeutic reaction to imatinib mesylate. The cloned NAP1L4-NUTM1 gene structure is also determined.

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Title: A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction
Authors: Zhao Cheng
Yunya Luo
Yang Zhang
Yewei Wang
Yi Chen
Yunxiao Xu
Honling Peng
Guangsen Zhang
Publication date: 01-07-2020
Publisher: Springer Berlin Heidelberg
Keywords: Eosinophilia
Imatinib
Published in: Annals of Hematology / Issue 7/2020
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-020-04000-x

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A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction

Abstract

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Abstract

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