Top

Abdominal Radiology

Published in:

01-08-2021 | Liver Transplantation | Hepatobiliary

Change in hepatic volume profile in potential live liver donors after lifestyle modification for reduction of hepatic steatosis

Authors: Hyo Jung Park, Kyoung Won Kim, Jeongjin Lee, Taeyong Park, Heon-Ju Kwon, Gi-Won Song, Sung-Gyu Lee

Published in: Abdominal Radiology | Issue 8/2021

Abstract

Purpose

We aimed to evaluate changes in hepatic volume and hemiliver volume percentage in potential liver donors after hepatic steatosis (HS) reduction through lifestyle modification.

Methods

Fifty liver donor candidates with HS (macrovesicular fat [MaF] ≥ 20%) underwent abdominal computed tomography (CT) and liver biopsy before (baseline) and after (follow-up) lifestyle modification. According to the change in MaF, subjects were classified as group A (MaF reduction ≥ 20%, n = 25), and group B (MaF reduction < 20%, n = 25). The hepatic volume and hemiliver volume percentage were measured using CT volumetric analysis.

Results

Volume percentage of the left hemiliver + S1 (over the whole liver) significantly increased at follow-up in group A (P < 0.001) but not in group B (P = 0.598). The absolute volume change of the right hemiliver and its percentage change from the baseline were significantly greater than those of the left hemiliver + S1 in group A (P < 0.007). There were no significant differences in these values in group B (P = 0.064 and 0.507, respectively). The percentage of subjects that earned the benefit of becoming suitable donors from the change in hepatic volume distribution caused by HS improvement was 52.0% (13/25) and 40.0% (10/25) in group A and group B, respectively. Regarding posthepatectomy liver failure, none was identified in group A after donation, whereas 12% (3/25) was identified in group B.

Conclusion

Hepatic volume profile may change considerably in potential liver donors with HS (MaF ≥ 20%) after HS reduction through lifestyle modification. Reevaluation of the hepatic volume is required before liver procurement after lifestyle modification in these subjects.

Available only for authorised users

Abdel Razek AAK, El-Serougy LG, Saleh GA, Shabana W, Abd El-Wahab R (20MMMM20) Liver Imaging Reporting and Data System Version 2018: What Radiologists Need to Know. J Comput Assist Tomogr 44 (2):168-177. https://doi.org/10.1097/rct.0000000000000995

deLemos AS, Vagefi PA (20MMMM13) Expanding the donor pool in liver transplantation: Extended criteria donors. Clin Liver Dis (Hoboken) 2 (4):156–159. https://doi.org/10.1002/cld.222

Perez-Daga JA, Santoyo J, Suarez MA, Fernandez-Aguilar JA, Ramirez C, Rodriguez-Canete A, Aranda JM, Sanchez-Perez B, Montiel C, Palomo D, Ruiz M, Mate A (20MMMM06) Influence of degree of hepatic steatosis on graft function and postoperative complications of liver transplantation. Transplant Proc 38 (8):2468–2470. https://doi.org/10.1016/j.transproceed.2006.08.077

Spitzer AL, Lao OB, Dick AA, Bakthavatsalam R, Halldorson JB, Yeh MM, Upton MP, Reyes JD, Perkins JD (20MMMM10) The biopsied donor liver: incorporating macrosteatosis into high-risk donor assessment. Liver Transpl 16 (7):874–884. https://doi.org/10.1002/lt.22085

Tang A, Chen J, Le TA, Changchien C, Hamilton G, Middleton MS, Loomba R, Sirlin CB (20MMMM15) Cross-sectional and longitudinal evaluation of liver volume and total liver fat burden in adults with nonalcoholic steatohepatitis. Abdom Imaging 40 (1):26–37. https://doi.org/10.1007/s00261-014-0175-0

Lewis MC, Phillips ML, Slavotinek JP, Kow L, Thompson CH, Toouli J (20MMMM06) Change in liver size and fat content after treatment with Optifast very low calorie diet. Obes Surg 16 (6):697–701. https://doi.org/10.1381/096089206777346682

Chen TY, Chen CL, Tsang LL, Huang TL, Wang CC, Concejero AM, Lu CH, Cheng YF (20MMMM08) Correlation between hepatic steatosis, hepatic volume, and spleen volume in live liver donors. Transplant Proc 40 (8):2481–2483. https://doi.org/10.1016/j.transproceed.2008.08.045

Bonekamp S, Tang A, Mashhood A, Wolfson T, Changchien C, Middleton MS, Clark L, Gamst A, Loomba R, Sirlin CB (20MMMM14) Spatial distribution of MRI-Determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease. J Magn Reson Imaging 39 (6):1525–1532. https://doi.org/10.1002/jmri.24321

Lee H, Jun DW, Kang BK, Nam E, Chang M, Kim M, Song S, Yoon BC, Lee HL, Lee OY, Choi HS, Lee KN (20MMMM17) Estimating of hepatic fat amount using MRI proton density fat fraction in a real practice setting. Medicine (Baltimore) 96 (33):e7778. https://doi.org/10.1097/MD.0000000000007778

10.

Choi Y, Lee JM, Yi NJ, Kim H, Park MS, Hong G, Yoo T, Suh SW, Lee HW, Lee KW, Suh KS (20MMMM15) Heterogeneous living donor hepatic fat distribution on MRI chemical shift imaging. Ann Surg Treat Res 89 (1):37–42. https://doi.org/10.4174/astr.2015.89.1.37

11.

Park HJ, Kim KW, Kwon JH, Lee J, Park T, Kwon HJ, Song GW, Lee SG (20MMMM20) Lifestyle modification leads to spatially variable reduction in hepatic steatosis in potential living liver donors. Liver Transpl 26 (4):487–497. https://doi.org/10.1002/lt.25733

12.

Lee SG (20MMMM15) A complete treatment of adult living donor liver transplantation: a review of surgical technique and current challenges to expand indication of patients. Am J Transplant 15 (1):17–38. https://doi.org/10.1111/ajt.12907

13.

Oja P, Titze S (20MMMM11) Physical activity recommendations for public health: development and policy context. EPMA J 2 (3):253–259. https://doi.org/10.1007/s13167-011-0090-1

14.

Laurent I, Astère M, Paul B, Liliane N, Li Y, Cheng Q, Li Q, Xiao X (20MMMM20) The use of Broca index to assess cut- off points for overweight in adults: A short review. Rev Endocr Metab Disord 21 (4):521–526. https://doi.org/10.1007/s11154-020-09566-5

15.

Oscai LB, Holloszy JO (19MMMM69) Effects of weight changes produced by exercise, food restriction, or overeating on body composition. J Clin Invest 48 (11):2124–2128. https://doi.org/10.1172/JCI106179

16.

Lee J, Kim N, Lee H, Seo JB, Won HJ, Shin YM, Shin YG, Kim SH (20MMMM07) Efficient liver segmentation using a level-set method with optimal detection of the initial liver boundary from level-set speed images. Comput Methods Programs Biomed 88 (1):26–38. https://doi.org/10.1016/j.cmpb.2007.07.005

17.

Malladi R, Sethian JA, Vemuri BC (19MMMM95) Shape modeling with front propagation - a level set approach. IEEE Trans Pattern Anal Mach Intell 17 (2):158–175. https://doi.org/10.1109/34.368173

18.

Kreyszig E (20MMMM06) Advanced Engineering Mathematics. 9th edn. John Wily & Sons, New York, USA

19.

Rahbari NN, Garden OJ, Padbury R, Brooke-Smith M, Crawford M, Adam R, Koch M, Makuuchi M, Dematteo RP, Christophi C, Banting S, Usatoff V, Nagino M, Maddern G, Hugh TJ, Vauthey JN, Greig P, Rees M, Yokoyama Y, Fan ST, Nimura Y, Figueras J, Capussotti L, Buchler MW, Weitz J (20MMMM11) Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery 149 (5):713–724. https://doi.org/10.1016/j.surg.2010.10.001

20.

Koo TK, Li MY (20MMMM16) A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. J Chiropr Med 15 (2):155–163. https://doi.org/10.1016/j.jcm.2016.02.012

21.

Incedayı M, Arıbal S, Sivrioğlu AK, Sönmez G, Oztürk E, Yalçın B, Başekim CÇ (20MMMM12) Are hepatic portal venous system components distributed equally in the liver? A multidetector computerized tomography study. Balkan Med J 29 (4):419–423. https://doi.org/10.5152/balkanmedj.2012.050

22.

Konopke R, Distler M, Ludwig S, Kersting S (20MMMM08) Location of liver metastases reflects the site of the primary colorectal carcinoma. Scand J Gastroenterol 43 (2):192–195. https://doi.org/10.1080/00365520701677755

23.

Miller CM, Durand F, Heimbach JK, Kim-Schluger L, Lee SG, Lerut J, Lo CM, Quintini C, Pomfret EA (20MMMM16) The International Liver Transplant Society guideline on living liver donation. Transplantation 100 (6):1238–1243. https://doi.org/10.1097/TP.0000000000001247

24.

Living donor liver transplantation: left or right lobe? (20MMMM06). Nat Rev Gastroenterol Hepatol 3 (7):360. https://doi.org/10.1038/ncpgasthep0504

25.

Park GC, Song GW, Moon DB, Lee SG (20MMMM16) A review of current status of living donor liver transplantation. Hepatobiliary Surg Nutr 5 (2):107–117. https://doi.org/10.3978/j.issn.2304-3881.2015.08.04

Title: Change in hepatic volume profile in potential live liver donors after lifestyle modification for reduction of hepatic steatosis
Authors: Hyo Jung Park
Kyoung Won Kim
Jeongjin Lee
Taeyong Park
Heon-Ju Kwon
Gi-Won Song
Sung-Gyu Lee
Publication date: 01-08-2021
Publisher: Springer US
Keywords: Liver Transplantation
Computed Tomography
Computed Tomography
Liver Transplantation
Fatty Liver
Liver Transplantation
Liver Transplantation
Liver Transplantation
Published in: Abdominal Radiology / Issue 8/2021
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-021-03058-z

ACC 2024 Congress Coverage

Heart Failure Video

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Change in hepatic volume profile in potential live liver donors after lifestyle modification for reduction of hepatic steatosis

Abstract

Purpose

Methods

Results

Conclusion

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 8/2021

LI-RADS treatment response algorithm for detecting incomplete necrosis in hepatocellular carcinoma after locoregional treatment: a systematic review and meta-analysis using individual patient data

Performance of imaging interpretation, intra- and inter-reader agreement for diagnosis of pelvic endometriosis: comparison between an abbreviated and full MRI protocol

Risk of nephrogenic systemic fibrosis in patients with impaired renal function undergoing fixed-dose gadoxetic acid-enhanced magnetic resonance imaging

Value of bowel preparation techniques for prostate MRI: a preliminary study

Can procedure time for paracentesis be optimized based on bottle selection?

Comparison of diffusion-weighted imaging and MR elastography in staging liver fibrosis: a meta-analysis

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page