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Abdominal Radiology
Published in: Abdominal Radiology 12/2020

01-12-2020 | Prostate Cancer | Special Section: Prostate cancer update

How should radiologists incorporate non-imaging prostate cancer biomarkers into daily practice?

Authors: Pawel Rajwa, Jamil Syed, Michael S. Leapman

Published in: Abdominal Radiology | Issue 12/2020

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Abstract

Objective

To review the current body of evidence surrounding non-imaging biomarkers in patients with known or suspected prostate cancer.

Results

Several non-imaging biomarkers have been developed and are available that aim to improve risk estimates at several clinical junctures. For patients with suspicion of prostate cancer who are considering first-time or repeat biopsy, blood- and urine-based assays can improve the prediction of harboring clinically significant disease and may reduce unnecessary biopsy. Blood- and urine-based biomarkers have been evaluated in association with prostate MRI, offering insights that might augment decision-making in the pre and post-MRI setting. Tissue-based genomic and proteomic assays have also been developed that provide independent assessments of prostate cancer aggressiveness that can complement imaging.

Conclusion

A growing number of non-imaging biomarkers are available to assist in clinical decision-making for men with known or suspected prostate cancer. An appreciation for the intersection of imaging and biomarkers may improve clinical care and resource utilization for men with prostate cancer.
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Metadata
Title
How should radiologists incorporate non-imaging prostate cancer biomarkers into daily practice?
Authors
Pawel Rajwa
Jamil Syed
Michael S. Leapman
Publication date
01-12-2020
Publisher
Springer US
Published in
Abdominal Radiology / Issue 12/2020
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-020-02496-5

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