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Abdominal Radiology

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01-05-2019 | Ultrasound | Kidneys, Ureters, Bladder, Retroperitoneum

Quantitative contrast-enhanced ultrasound of renal perfusion: a technology for the assessment of early diabetic nephropathy in cynomolgus macaques with type 2 diabetes mellitus

Authors: Jieli Luo, Jianshe Chen, Yang Sun, Hang Zhou, Kailun Xu, Fengbo Huang, Pintong Huang

Published in: Abdominal Radiology | Issue 5/2019

Abstract

Purpose

The aim of this study was to investigate the effectiveness of contrast-enhanced ultrasound (CEUS) in predicting early nephropathy in cynomolgus macaques with spontaneous type 2 diabetes mellitus (T2DM).

Methods

Six cynomolgus macaques with spontaneous T2DM and six normal cynomolgus macaques (Group 1) were included in this study. The time–intensity curve was used to obtain parameters such as peak values, red blood volume (RBV), red blood flow (RBF), time to peak (TTP), and mean transit time (MTT). Biopsy renal tissue samples were assessed histopathologically. Six cynomolgus macaques with spontaneous T2DM were subgrouped into T2DM without nephropathy group (Group 2) and T2DM with nephropathy group (Group 3) based on histopathological findings.

Results

Peak value had the largest area under the curve comparing with RBF, RBV, TTP, MTT. The sensitivity and specificity of peak value with cut-off value of 38.65 dB for the diagnosis of DN were 98.3% and 83%, respectively. Peak value, RBV, and RBF in Group 3 was significantly decreased compared with Group 1 and Group 2 (P = 0.000, x² = 23.99; P = 0.003, x² = 9.14; P = 0.02, x² = 5.14).

Conclusions

The perfusion parameter of peak value in CEUS might be useful in predicting early diabetic nephropathy in spontaneous T2DM cynomolgus macaques.

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Title: Quantitative contrast-enhanced ultrasound of renal perfusion: a technology for the assessment of early diabetic nephropathy in cynomolgus macaques with type 2 diabetes mellitus
Authors: Jieli Luo
Jianshe Chen
Yang Sun
Hang Zhou
Kailun Xu
Fengbo Huang
Pintong Huang
Publication date: 01-05-2019
Publisher: Springer US
Keywords: Ultrasound
Diabetic Nephropathy
Microalbuminuria
Ultrasound
Diabetes
Type 2 Diabetes
Published in: Abdominal Radiology / Issue 5/2019
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-019-01908-5

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Quantitative contrast-enhanced ultrasound of renal perfusion: a technology for the assessment of early diabetic nephropathy in cynomolgus macaques with type 2 diabetes mellitus

Abstract

Purpose

Methods

Results

Conclusions

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