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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 10/2019

01-09-2019 | Computed Tomography | Original Article

European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma

Authors: David Taïeb, Rodney J. Hicks, Elif Hindié, Benjamin A. Guillet, Anca Avram, Pietro Ghedini, Henri J. Timmers, Aaron T. Scott, Saeed Elojeimy, Domenico Rubello, Irène J. Virgolini, Stefano Fanti, Sona Balogova, Neeta Pandit-Taskar, Karel Pacak

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2019

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Abstract

Purpose

Diverse radionuclide imaging techniques are available for the diagnosis, staging, and follow-up of phaeochromocytoma and paraganglioma (PPGL). Beyond their ability to detect and localise the disease, these imaging approaches variably characterise these tumours at the cellular and molecular levels and can guide therapy. Here we present updated guidelines jointly approved by the EANM and SNMMI for assisting nuclear medicine practitioners in not only the selection and performance of currently available single-photon emission computed tomography and positron emission tomography procedures, but also the interpretation and reporting of the results.

Methods

Guidelines from related fields and relevant literature have been considered in consultation with leading experts involved in the management of PPGL. The provided information should be applied according to local laws and regulations as well as the availability of various radiopharmaceuticals.

Conclusion

Since the European Association of Nuclear Medicine 2012 guidelines, the excellent results obtained with gallium-68 (68Ga)-labelled somatostatin analogues (SSAs) in recent years have simplified the imaging approach for PPGL patients that can also be used for selecting patients for peptide receptor radionuclide therapy as a potential alternative or complement to the traditional theranostic approach with iodine-123 (123I)/iodine-131 (131I)-labelled meta-iodobenzylguanidine. Genomic characterisation of subgroups with differing risk of lesion development and subsequent metastatic spread is refining the use of molecular imaging in the personalised approach to hereditary PPGL patients for detection, staging, and follow-up surveillance.
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Metadata
Title
European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma
Authors
David Taïeb
Rodney J. Hicks
Elif Hindié
Benjamin A. Guillet
Anca Avram
Pietro Ghedini
Henri J. Timmers
Aaron T. Scott
Saeed Elojeimy
Domenico Rubello
Irène J. Virgolini
Stefano Fanti
Sona Balogova
Neeta Pandit-Taskar
Karel Pacak
Publication date
01-09-2019
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2019
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-019-04398-1

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