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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 6/2005

01-06-2005 | Image of the Month

68Ga-DOTANOC: a first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5

Authors: Damian Wild, Helmut R. Mäcke, Beatrice Waser, Jean Claude Reubi, Mihaela Ginj, Helmut Rasch, Jan Müller-Brand, Michael Hofmann

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 6/2005

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Excerpt

Existing somatostatin-based radiotracers (e.g. 111In-DOTATOC) have sole affinity for somatostatin receptor subtype 2 (sst2). This represents a drawback, given that sst1–5 have been shown to be over-expressed in different tumours, alone or concomitantly [1]. Our goal, therefore, was to develop radiopeptides with broader receptor subtype profiles. …
Literature
1.
Reubi JC, Waser B. Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting. Eur J Nucl Med Mol Imaging (Review) 2003;30:781–93.
2.
Wild D, Schmitt JS, Ginj M, Macke HR, Bernard BF, Krenning E, et al. DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals. Eur J Nucl Med Mol Imaging 2003;30:1338–47.CrossRefPubMed
3.
Hofmann M, Maecke HR, Börner AR, Weckesser E, Schöffski P, Oei ML, et al. Biokinetics and imaging with the somatostatin receptor PET radioligand 68Ga-DOTATOC: preliminary data. Eur J Nucl Med 2001;28:1751–7.CrossRefPubMed
Metadata
Title
68Ga-DOTANOC: a first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5
Authors
Damian Wild
Helmut R. Mäcke
Beatrice Waser
Jean Claude Reubi
Mihaela Ginj
Helmut Rasch
Jan Müller-Brand
Michael Hofmann
Publication date
01-06-2005
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 6/2005
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-004-1697-4

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