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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-08-2015 | Original Article

Quantifying [¹⁸F]fluorodeoxyglucose uptake in the arterial wall: the effects of dual time-point imaging and partial volume effect correction

Authors: Björn A. Blomberg, Arjun Bashyam, Abhinay Ramachandran, Saeid Gholami, Sina Houshmand, Ali Salavati, Tom Werner, Habib Zaidi, Abass Alavi

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2015

Abstract

Purpose

The human arterial wall is smaller than the spatial resolution of current positron emission tomographs. Therefore, partial volume effects should be considered when quantifying arterial wall ¹⁸F-FDG uptake. We evaluated the impact of a novel method for partial volume effect (PVE) correction with contrast-enhanced CT (CECT) assistance on quantification of arterial wall ¹⁸F-FDG uptake at different imaging time-points.

Methods

Ten subjects were assessed by CECT imaging and dual time-point PET/CT imaging at approximately 60 and 180 min after ¹⁸F-FDG administration. For both time-points, uptake of ¹⁸F-FDG was determined in the aortic wall by calculating the blood pool-corrected maximum standardized uptake value (cSUV_MAX) and cSUV_MEAN. The PVE-corrected SUV_MEAN (pvcSUV_MEAN) was also calculated using ¹⁸F-FDG PET/CT and CECT images. Finally, corresponding target-to-background ratios (TBR) were calculated.

Results

At 60 min, pvcSUV_MEAN was on average 3.1 times greater than cSUV_MAX (P < .0001) and 8.5 times greater than cSUV_MEAN (P < .0001). At 180 min, pvcSUV_MEAN was on average 2.6 times greater than cSUV_MAX (P < .0001) and 6.6 times greater than cSUV_MEAN (P < .0001).

Conclusion

This study demonstrated that CECT-assisted PVE correction significantly influences quantification of arterial wall ¹⁸F-FDG uptake. Therefore, partial volume effects should be considered when quantifying arterial wall ¹⁸F-FDG uptake with PET.

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Title: Quantifying [18F]fluorodeoxyglucose uptake in the arterial wall: the effects of dual time-point imaging and partial volume effect correction
Authors: Björn A. Blomberg
Arjun Bashyam
Abhinay Ramachandran
Saeid Gholami
Sina Houshmand
Ali Salavati
Tom Werner
Habib Zaidi
Abass Alavi
Publication date: 01-08-2015
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2015
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-015-3074-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Quantifying [¹⁸F]fluorodeoxyglucose uptake in the arterial wall: the effects of dual time-point imaging and partial volume effect correction

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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