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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-03-2014 | Original Article

Factors affecting the myocardial activity acquired during exercise SPECT with a high-sensitivity cardiac CZT camera as compared with conventional Anger camera

Authors: Antoine Verger, Laetitia Imbert, Yalcine Yagdigul, Renaud Fay, Wassila Djaballah, François Rouzet, Nicolas Fourquet, Sylvain Poussier, Véronique Roch, Dominique Le Guludec, Gilles Karcher, Pierre-Yves Marie

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2014

Abstract

Purpose

Injected doses are difficult to optimize for exercise SPECT since they depend on the myocardial fraction of injected activity (MFI) that is detected by the camera. The aim of this study was to analyse the factors affecting MFI determined using a cardiac CZT camera as compared with those determined using conventional Anger cameras.

Methods

Factors affecting MFI were determined and compared in patients who had consecutive exercise SPECT acquisitions with ²⁰¹Tl (84 patients) or ^99mTc-sestamibi (87 patients) with an Anger or a CZT camera. A predictive model was validated in a group of patients routinely referred for ²⁰¹Tl (78 patients) or ^99mTc-sestamibi (80 patients) exercise CZT SPECT.

Results

The predictive model involved: (1) camera type, adjusted mean MFI being ninefold higher for CZT than for Anger SPECT, (2) tracer type, adjusted mean MFI being twofold higher for ²⁰¹Tl than for ^99mTc-sestamibi, and (3) logarithm of body weight. The CZT SPECT model led to a +1 ± 26 % error in the prediction of the actual MFI from the validation group. The mean MFI values estimated for CZT SPECT were more than twofold higher in patients with a body weight of 60 kg than in patients with a body weight of 120 kg (15.9 and 6.8 ppm for ^99mTc-sestamibi and 30.5 and 13.1ppm for ²⁰¹Tl, respectively), and for a 14-min acquisition of up to one million myocardial counts, the corresponding injected activities were only 80 and 186 MBq for ^99mTc-sestamibi and 39 and 91 MBq for ²⁰¹Tl, respectively.

Conclusion

Myocardial activities acquired during exercise CZT SPECT are strongly influenced by body weight and tracer type, and are dramatically higher than those obtained using an Anger camera, allowing very low-dose protocols to be planned, especially for ^99mTc-sestamibi and in non-obese subjects.

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Title: Factors affecting the myocardial activity acquired during exercise SPECT with a high-sensitivity cardiac CZT camera as compared with conventional Anger camera
Authors: Antoine Verger
Laetitia Imbert
Yalcine Yagdigul
Renaud Fay
Wassila Djaballah
François Rouzet
Nicolas Fourquet
Sylvain Poussier
Véronique Roch
Dominique Le Guludec
Gilles Karcher
Pierre-Yves Marie
Publication date: 01-03-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2014
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2617-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Factors affecting the myocardial activity acquired during exercise SPECT with a high-sensitivity cardiac CZT camera as compared with conventional Anger camera

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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