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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-02-2013 | Original Article

Comparison between stress myocardial perfusion SPECT recorded with cadmium-zinc-telluride and Anger cameras in various study protocols

Authors: Antoine Verger, Wassila Djaballah, Nicolas Fourquet, François Rouzet, Grégoire Koehl, Laetitia Imbert, Sylvain Poussier, Renaud Fay, Véronique Roch, Dominique Le Guludec, Gilles Karcher, Pierre-Yves Marie

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2013

Abstract

Purpose

The results of stress myocardial perfusion SPECT could be enhanced by new cadmium-zinc-telluride (CZT) cameras, although differences compared to the results with conventional Anger cameras remain poorly known for most study protocols. This study was aimed at comparing the results of CZT and Anger SPECT according to various study protocols while taking into account the influence of obesity.

Methods

The study population, which was from three different institutions equipped with identical CZT cameras, comprised 276 patients referred for study using protocols involving ²⁰¹Tl (n = 120) or ^99mTc-sestamibi injected at low dose at stress (^99mTc-Low; stress/rest 1-day protocol; n = 110) or at high dose at stress (^99mTc-High; rest/stress 1-day or 2-day protocol; n = 46). Each Anger SPECT scan was followed by a high-speed CZT SPECT scan (2 to 4 min).

Results

Agreement rates between CZT and Anger SPECT were good irrespective of the study protocol (for abnormal SPECT, ²⁰¹Tl 92 %, ^99mTc-Low 86 %, ^99mTc-High 98 %), although quality scores were much higher for CZT SPECT with all study protocols. Overall correlations were high for the extent of myocardial infarction (r = 0.80) and a little lower for ischaemic areas (r = 0.72), the latter being larger on Anger SPECT (p < 0.001). This larger extent was mainly observed in 50 obese patients who were in the ²⁰¹Tl or ^99mTc-Low group and in whom stress myocardial counts were particularly low with Anger SPECT (228 ± 101 kcounts) and dramatically enhanced with CZT SPECT (+279 ± 251 %).

Conclusion

Concordance between the results of CZT and Anger SPECT is good regardless of study protocol and especially when excluding obese patients who have low-count Anger SPECT and for whom myocardial counts are dramatically enhanced on CZT SPECT.

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Title: Comparison between stress myocardial perfusion SPECT recorded with cadmium-zinc-telluride and Anger cameras in various study protocols
Authors: Antoine Verger
Wassila Djaballah
Nicolas Fourquet
François Rouzet
Grégoire Koehl
Laetitia Imbert
Sylvain Poussier
Renaud Fay
Véronique Roch
Dominique Le Guludec
Gilles Karcher
Pierre-Yves Marie
Publication date: 01-02-2013
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2013
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-012-2292-8

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Comparison between stress myocardial perfusion SPECT recorded with cadmium-zinc-telluride and Anger cameras in various study protocols

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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