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Pediatric Radiology

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01-11-2017 | Letter to the Editor

Reply to Lancelot et al.: ‘Lack of evidence of a relationship between magnetic resonance signal intensity changes in the globus pallidus and dentate nucleus, and repeated administrations of gadoterate meglumine in children’

Authors: Maria Camilla Rossi Espagnet, Paolo Tomà, Antonio Napolitano

Published in: Pediatric Radiology | Issue 12/2017

Excerpt

Dear Editors, …

Lancelot E, Raynaud J-S, Desché P (2017) Lack of evidence of a relationship between magnetic resonance signal intensity changes in the globus pallidus and dentate nucleus, and repeated administrations of gadoterate meglumine in children. Pediatri Radiol. https://doi.org/10.1007/s00247-017-3947-1

Rossi Espagnet CA, Bernardi B, Pasquini L et al (2017) Signal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children. Pediatr Radiol 47:633–648CrossRefPubMed

Murata N, Gonzalez-Cuyar LF, Murata K et al (2016) Macrocyclic and other non-group 1 gadolinium contrast agents deposit low levels of gadolinium in brain and bone tissue: preliminary results from 9 patients with normal renal function. Investig Radiol 51:447–453CrossRef

Ramalho J, Semelka R, AlObaidy M et al (2016) Signal intensity change on unenhanced T1-weighted images of the dentate nucleus following gadobenate dimeglumine in patients with and without previous multiple administrations of gadodiamide. Eur Radiol 26:4080–4088CrossRefPubMed

Weberling LD, Kieslich PJ, Kickingereder P et al (2016) Increased signal intensity in the dentate nucleus on unenhanced T1-weighted images after gadobenate dimeglumine administration. Investig Radiol 50:743–748CrossRef

Radbruch A, Weberling LD, Kieslich PJ et al (2016) High-signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted images: evaluation of the macrocyclic gadolinium-based contrast agent gadobutrol. Investig Radiol 50:805–810CrossRef

Radbruch A, Weberling LD, Kieslich PJ et al (2016) Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent. Radiology 275:783–791CrossRef

Radbruch A, Haase R, Kickingereder P et al (2017) Pediatric brain: no increased signal intensity in the dentate nucleus on unenhanced T1-weighted MR images after consecutive exposure to a macrocyclic gadolinium-based contrast agent. Radiology 283:828–836CrossRefPubMed

Hu HH, Pokorney A, Towbin RB et al (2016) Increased signal intensities in the dentate nucleus and globus pallidus on unenhanced T1-weighted images: evidence in children undergoing multiple gadolinium MRI exams. Pediatr Radiol 46:1590–1598CrossRefPubMed

10.

Kahn J, Posch H, Steffen IG et al (2017) Is there long-term signal intensity increase in the central nervous system on T1-weighted images after MR imaging with the hepatospecific contrast agent gadoxetic acid? A cross-sectional study in 91 patients. Radiology 282:708–716CrossRefPubMed

11.

Tedeschi E, Palma G, Canna A et al (2016) In vivo dentate nucleus MRI relaxometry correlates with previous administration of gadolinium-based contrast agents. Eur Radiol 26:4577–4584CrossRefPubMed

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Flood TF, Stence NV, Maloney JA et al (2017) Pediatric brain: repeated exposure to linear gadolinium-based contrast material is associated with increased signal intensity at unenhanced T1-weighted MR imaging. Radiology 282:222–228CrossRefPubMed

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Smith AP, Marino M, Roberts J et al (2017) Clearance of gadolinium from the brain with no pathologic effect after repeated administration of gadodiamide in healthy rats: an analytical and histologic study. Radiology 282:743–751CrossRefPubMed

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Adin ME, Kleinberg L, Vaidya D et al (2015) Hyperintense dentate nuclei on T1-weighted MRI: relation to repeat gadolinium administration. AJNR Am J Neuroradiol 36:1859–1865CrossRefPubMedPubMedCentral

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Ramalho J, Ramalho M, AlObaidy M et al (2016) T1 signal-intensity increase in the dentate nucleus after multiple exposures to gadodiamide: intraindividual comparison between 2 commonly used sequences. AJNR Am J Neuroradiol 37:1427–1431CrossRefPubMed

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Shen Y, Goerner FL, Snyder C et al (2015) T1 relaxivities of gadolinium-based magnetic resonance contrast agents in human whole blood at 1.5, 3, and 7 T. Investig Radiol 50:330–338CrossRef

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Roberts DR, Welsh CA, DP LB 2nd, Davis WC (2017) Distribution map of gadolinium deposition within the cerebellum following GBCA administration. Neurology 88:1206–1208CrossRefPubMed

Title: Reply to Lancelot et al.: ‘Lack of evidence of a relationship between magnetic resonance signal intensity changes in the globus pallidus and dentate nucleus, and repeated administrations of gadoterate meglumine in children’
Authors: Maria Camilla Rossi Espagnet
Paolo Tomà
Antonio Napolitano
Publication date: 01-11-2017
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Radiology / Issue 12/2017
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-017-3948-0

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