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01-12-2016 | Magnetic Resonance

In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents

Authors: Enrico Tedeschi, Giuseppe Palma, Antonietta Canna, Sirio Cocozza, Carmela Russo, Pasquale Borrelli, Roberta Lanzillo, Valentina Angelini, Emanuela Postiglione, Vincenzo Brescia Morra, Marco Salvatore, Arturo Brunetti, Mario Quarantelli

Published in: European Radiology | Issue 12/2016

Abstract

Objectives

To evaluate changes in T1 and T2* relaxometry of dentate nuclei (DN) with respect to the number of previous administrations of Gadolinium-based contrast agents (GBCA).

Methods

In 74 relapsing-remitting multiple sclerosis (RR-MS) patients with variable disease duration (9.8±6.8 years) and severity (Expanded Disability Status Scale scores:3.1±0.9), the DN R1 (1/T1) and R2* (1/T2*) relaxation rates were measured using two unenhanced 3D Dual-Echo spoiled Gradient-Echo sequences with different flip angles. Correlations of the number of previous GBCA administrations with DN R1 and R2* relaxation rates were tested, including gender and age effect, in a multivariate regression analysis.

Results

The DN R1 (normalized by brainstem) significantly correlated with the number of GBCA administrations (p<0.001), maintaining the same significance even when including MS-related factors. Instead, the DN R2* values correlated only with age (p=0.003), and not with GBCA administrations (p=0.67). In a subgroup of 35 patients for whom the administered GBCA subtype was known, the effect of GBCA on DN R1 appeared mainly related to linear GBCA.

Conclusions

In RR-MS patients, the number of previous GBCA administrations correlates with R1 relaxation rates of DN, while R2* values remain unaffected, suggesting that T1-shortening in these patients is related to the amount of Gadolinium given.

Key Points

• In multiple sclerosis, previous Gadolinium administrations correlate with dentate nuclei T1 relaxometry.

• Such correlation is linked to linear Gadolinium chelates and unrelated to disease duration or severity.

• Dentate nuclei T2* relaxometry is age-related and independent of previous Gadolinium administrations.

• Changes in dentate nuclei T1 relaxometry are not determined by iron accumulation.

• MR relaxometry can quantitatively assess Gadolinium accumulation in dentate nuclei.

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Title: In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents
Authors: Enrico Tedeschi
Giuseppe Palma
Antonietta Canna
Sirio Cocozza
Carmela Russo
Pasquale Borrelli
Roberta Lanzillo
Valentina Angelini
Emanuela Postiglione
Vincenzo Brescia Morra
Marco Salvatore
Arturo Brunetti
Mario Quarantelli
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 12/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4245-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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