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Published in: Pediatric Cardiology 5/2014

01-06-2014 | Original Article

Patient Radiation Exposure in a Modern, Large-Volume, Pediatric Cardiac Catheterization Laboratory

Authors: Andrew C. Glatz, Akash Patel, Xiaowei Zhu, Yoav Dori, Brian D. Hanna, Matthew J. Gillespie, Jonathan J. Rome

Published in: Pediatric Cardiology | Issue 5/2014

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Abstract

Radiation exposure from pediatric cardiac catheterization may be substantial, although published estimates vary. We sought to report patient radiation dose across a range of diagnostic and interventional cases in a modern, high-volume pediatric catheterization laboratory. We retrospectively reviewed diagnostic and interventional cases performed in our pediatric catheterization laboratory from 1 April 2009 to 30 September 2011 for which radiation usage data were available as reported by the Artis Zee® (Siemens Medical Solutions) system. Electrophysiology cases were excluded. Radiation dose was quantified as air kerma dose (mGy) and dose-area product (DAP; μGy m2). The DAP was converted to an effective dose millisievert (mSv) using the Monte Carlo method. Radiation usage data were available from 2,265 diagnostic and interventional cases with an overall median air kerma dose of 135 mGy [interquartile range (IQR) 59–433], median DAP of 760 μGy m2 (IQR 281–2,810), of which 75 % (IQR 59–90 %) was derived from fluoroscopy, and median effective dose of 6.2 mSv (IQR 2.7–14.1). Air kerma dose from a single camera >2,000 mGy occurred in 1.8 % of cases. Significant differences in all measures of radiation exposure existed based on procedural and interventional types (p = 0.0001), with interventional cases associated with the highest effective dose after adjusting for patient weight category (p < 0.001). Patient weight, age, fluoroscopy time, and proportional use of digital acquisition were independent predictors of exposure (p ≤ 0.001; R 2 = 0.59–0.64). In a modern, large-volume pediatric catheterization laboratory, the median effective dose is 6.2 mSv with a wide range of exposure based on patient- and procedure-specific factors. Radiation monitoring is an important component of a pediatric laboratory and further dose reduction strategies are warranted.
Literature
1.
go back to reference Adams FH, Norman A, Bass D, Oku G (1978) Chromosome damage in infants and children after cardiac catheterization and angiocardiography. Pediatrics 62(3):312–316PubMed Adams FH, Norman A, Bass D, Oku G (1978) Chromosome damage in infants and children after cardiac catheterization and angiocardiography. Pediatrics 62(3):312–316PubMed
2.
go back to reference Al-Haj AN, Lobriguito AM, Rafeh W (2008) Variation in radiation doses in paediatric cardiac catheterisation procedures. Radiat Prot Dosimetry 129(1–3):173–178CrossRefPubMed Al-Haj AN, Lobriguito AM, Rafeh W (2008) Variation in radiation doses in paediatric cardiac catheterisation procedures. Radiat Prot Dosimetry 129(1–3):173–178CrossRefPubMed
3.
go back to reference Andreassi MG (2009) Radiation risk from pediatric cardiac catheterization: friendly fire on children with congenital heart disease. Circulation 120(19):1847–1849CrossRefPubMed Andreassi MG (2009) Radiation risk from pediatric cardiac catheterization: friendly fire on children with congenital heart disease. Circulation 120(19):1847–1849CrossRefPubMed
4.
go back to reference Andreassi MG, Ait-Ali L, Botto N, Manfredi S, Mottola G, Picano E (2006) Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease. Eur Heart J 27(22):2703–2708CrossRefPubMed Andreassi MG, Ait-Ali L, Botto N, Manfredi S, Mottola G, Picano E (2006) Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease. Eur Heart J 27(22):2703–2708CrossRefPubMed
5.
6.
go back to reference Bacher K, Bogaert E, Lapere R, De Wolf D, Thierens H (2005) Patient-specific dose and radiation risk estimation in pediatric cardiac catheterization. Circulation 111(1):83–89CrossRefPubMed Bacher K, Bogaert E, Lapere R, De Wolf D, Thierens H (2005) Patient-specific dose and radiation risk estimation in pediatric cardiac catheterization. Circulation 111(1):83–89CrossRefPubMed
7.
go back to reference Bakalyar DM, Castellani MD, Safian RD (1997) Radiation exposure to patients undergoing diagnostic and interventional cardiac catheterization procedures. Cathet Cardiovasc Diagn 42(2):121–125CrossRefPubMed Bakalyar DM, Castellani MD, Safian RD (1997) Radiation exposure to patients undergoing diagnostic and interventional cardiac catheterization procedures. Cathet Cardiovasc Diagn 42(2):121–125CrossRefPubMed
8.
go back to reference Beels L, Bacher K, De Wolf D, Werbrouck J, Thierens H (2009) Gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks? Circulation 120(19):1903–1909CrossRefPubMed Beels L, Bacher K, De Wolf D, Werbrouck J, Thierens H (2009) Gamma-H2AX foci as a biomarker for patient X-ray exposure in pediatric cardiac catheterization: are we underestimating radiation risks? Circulation 120(19):1903–1909CrossRefPubMed
9.
go back to reference Bergersen L, Marshall A, Gauvreau K, Beekman R, Hirsch R, Foerster S et al (2010) Adverse event rates in congenital cardiac catheterization: a multi-center experience. Catheter Cardiovasc Interv 75(3):389–400PubMed Bergersen L, Marshall A, Gauvreau K, Beekman R, Hirsch R, Foerster S et al (2010) Adverse event rates in congenital cardiac catheterization: a multi-center experience. Catheter Cardiovasc Interv 75(3):389–400PubMed
10.
go back to reference Berrington de Gonzalez A, Darby S (2004) Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries. Lancet 363(9406):345–351CrossRefPubMed Berrington de Gonzalez A, Darby S (2004) Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries. Lancet 363(9406):345–351CrossRefPubMed
11.
go back to reference Boothroyd A, McDonald E, Moores BM, Sluming V, Carty H (1997) Radiation exposure to children during cardiac catheterization. Br J Radiol 70:180–185CrossRefPubMed Boothroyd A, McDonald E, Moores BM, Sluming V, Carty H (1997) Radiation exposure to children during cardiac catheterization. Br J Radiol 70:180–185CrossRefPubMed
12.
go back to reference Brenner DJ, Elliston CD, Hall EJ, Berdon WE (2001) Estimated risks of radiation-induced fatal cancer from pediatric CT. Am J Roentgenol 176(2):289–296CrossRef Brenner DJ, Elliston CD, Hall EJ, Berdon WE (2001) Estimated risks of radiation-induced fatal cancer from pediatric CT. Am J Roentgenol 176(2):289–296CrossRef
13.
go back to reference Brody AS, Frush DP, Huda W, Brent RL (2007) Radiation risk to children from computed tomography. Pediatrics 120(3):677–682CrossRefPubMed Brody AS, Frush DP, Huda W, Brent RL (2007) Radiation risk to children from computed tomography. Pediatrics 120(3):677–682CrossRefPubMed
14.
go back to reference Cardis E, Vrijheid M, Blettner M, Gilbert E, Hakama M, Hill C et al (2007) The 15-country collaborative study of cancer risk among radiation workers in the nuclear industry: estimates of radiation-related cancer risks. Radiat Res 167(4):396–416CrossRefPubMed Cardis E, Vrijheid M, Blettner M, Gilbert E, Hakama M, Hill C et al (2007) The 15-country collaborative study of cancer risk among radiation workers in the nuclear industry: estimates of radiation-related cancer risks. Radiat Res 167(4):396–416CrossRefPubMed
15.
go back to reference Chambers CE, Fetterly KA, Holzer R, Lin PJP, Blankenship JC, Balter S et al (2011) Radiation safety program for the cardiac catheterization laboratory. Catheter Cardiovasc Interv 77(4):546–556CrossRefPubMed Chambers CE, Fetterly KA, Holzer R, Lin PJP, Blankenship JC, Balter S et al (2011) Radiation safety program for the cardiac catheterization laboratory. Catheter Cardiovasc Interv 77(4):546–556CrossRefPubMed
16.
go back to reference Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation; Board on Radiation Effects Research (BRER); Division on Earth and Life Studies (DELS); National Research Council (2006) Health risks from exposure to low levels of ionizing radiation: BEIR VII phase 2. The National Academies Press, Washington, DC Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation; Board on Radiation Effects Research (BRER); Division on Earth and Life Studies (DELS); National Research Council (2006) Health risks from exposure to low levels of ionizing radiation: BEIR VII phase 2. The National Academies Press, Washington, DC
17.
go back to reference Dragusin O, Gewillig M, Desmet W, Smans K, Struelens L, Bosmans H (2008) Radiation dose survey in a paediatric cardiac catheterisation laboratory equipped with flat-panel detectors. Radiat Prot Dosimetry 129(1–3):91–95CrossRefPubMed Dragusin O, Gewillig M, Desmet W, Smans K, Struelens L, Bosmans H (2008) Radiation dose survey in a paediatric cardiac catheterisation laboratory equipped with flat-panel detectors. Radiat Prot Dosimetry 129(1–3):91–95CrossRefPubMed
18.
go back to reference El Sayed MH, Roushdy AM, El Farghaly H, El Sherbini A (2012) Radiation exposure in children during the current era of pediatric cardiac intervention. Pediatr Cardiol 33(1):27–35CrossRefPubMed El Sayed MH, Roushdy AM, El Farghaly H, El Sherbini A (2012) Radiation exposure in children during the current era of pediatric cardiac intervention. Pediatr Cardiol 33(1):27–35CrossRefPubMed
19.
go back to reference Fetterly KA, Mathew V, Lennon R, Bell MR, Holmes DR, Rihal CS (2012) Radiation dose reduction in the invasive cardiovascular laboratory implementing a culture and philosophy of radiation safety. JACC Cardiovasc Interv 5(8):867–873CrossRef Fetterly KA, Mathew V, Lennon R, Bell MR, Holmes DR, Rihal CS (2012) Radiation dose reduction in the invasive cardiovascular laboratory implementing a culture and philosophy of radiation safety. JACC Cardiovasc Interv 5(8):867–873CrossRef
20.
go back to reference Glatz AC, Zhu X, Gillespie MJ, Hanna BD, Rome JJ (2010) Use of angiographic CT imaging in the cardiac catheterization laboratory for congenital heart disease. JACC Cardiovasc Imaging 3(11):1149–1157CrossRefPubMed Glatz AC, Zhu X, Gillespie MJ, Hanna BD, Rome JJ (2010) Use of angiographic CT imaging in the cardiac catheterization laboratory for congenital heart disease. JACC Cardiovasc Imaging 3(11):1149–1157CrossRefPubMed
21.
go back to reference Hall EJ (2002) Lessons we have learned from our children: cancer risks from diagnostic radiology. Pediatr Radiol 32(10):700–706CrossRefPubMed Hall EJ (2002) Lessons we have learned from our children: cancer risks from diagnostic radiology. Pediatr Radiol 32(10):700–706CrossRefPubMed
22.
go back to reference Hirshfeld JW, Balter SD, Brinker JA, Kern MJ, Klein LW, Lindsay BD et al (2005) ACCF/AHA/HRS/SCAI clinical competence statement on physician knowledge to optimize patient safety and image quality in fluoroscopically guided invasive cardiovascular procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and Training. Circulation 111(4):511–532CrossRefPubMed Hirshfeld JW, Balter SD, Brinker JA, Kern MJ, Klein LW, Lindsay BD et al (2005) ACCF/AHA/HRS/SCAI clinical competence statement on physician knowledge to optimize patient safety and image quality in fluoroscopically guided invasive cardiovascular procedures: a report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and Training. Circulation 111(4):511–532CrossRefPubMed
23.
go back to reference ICRP (1991) Recommendations of the International Commission on Radiologic Protection. Pergamon, Oxford ICRP (1991) Recommendations of the International Commission on Radiologic Protection. Pergamon, Oxford
24.
go back to reference Jabbari K (2011) Review of fast Monte Carlo codes for dose calculation in radiation therapy treatment planning. J Med Signals Sens 1(1):73–86PubMedCentralPubMed Jabbari K (2011) Review of fast Monte Carlo codes for dose calculation in radiation therapy treatment planning. J Med Signals Sens 1(1):73–86PubMedCentralPubMed
25.
go back to reference Justino H (2006) The ALARA concept in pediatric cardiac catheterization: techniques and tactics for managing radiation dose. Pediatr Radiol 36(Suppl 2):146–153PubMedCentralCrossRefPubMed Justino H (2006) The ALARA concept in pediatric cardiac catheterization: techniques and tactics for managing radiation dose. Pediatr Radiol 36(Suppl 2):146–153PubMedCentralCrossRefPubMed
26.
27.
go back to reference Li LB, Kai M, Kusama T (2001) Radiation exposure to patients during paediatric cardiac catheterisation. Radiat Prot Dosimetry 94(4):323–327CrossRefPubMed Li LB, Kai M, Kusama T (2001) Radiation exposure to patients during paediatric cardiac catheterisation. Radiat Prot Dosimetry 94(4):323–327CrossRefPubMed
28.
go back to reference Martin CJ (2008) The application of effective dose to medical exposures. Radiat Prot Dosimetry 128(1):1–4CrossRefPubMed Martin CJ (2008) The application of effective dose to medical exposures. Radiat Prot Dosimetry 128(1):1–4CrossRefPubMed
29.
go back to reference Martin EC, Olson A (1980) Radiation exposure to the paediatric patient from cardiac catheterization and angiocardiography. Br J Radiol 53(626):100–106CrossRefPubMed Martin EC, Olson A (1980) Radiation exposure to the paediatric patient from cardiac catheterization and angiocardiography. Br J Radiol 53(626):100–106CrossRefPubMed
30.
go back to reference Martin EC, Olson AP, Steeg CN, Casarella WJ (1981) Radiation exposure to the pediatric patient during cardiac catheterization and angiocardiography: emphasis on the thyroid gland. Circulation 64(1):153–158CrossRefPubMed Martin EC, Olson AP, Steeg CN, Casarella WJ (1981) Radiation exposure to the pediatric patient during cardiac catheterization and angiocardiography: emphasis on the thyroid gland. Circulation 64(1):153–158CrossRefPubMed
31.
go back to reference Martinez LC, Vano E, Gutierrez F, Rodriguez C, Gilarranz R, Manzanas MJ (2007) Patient doses from fluoroscopically guided cardiac procedures in pediatrics. Phys Med Biol 52(16):4749–4759CrossRefPubMed Martinez LC, Vano E, Gutierrez F, Rodriguez C, Gilarranz R, Manzanas MJ (2007) Patient doses from fluoroscopically guided cardiac procedures in pediatrics. Phys Med Biol 52(16):4749–4759CrossRefPubMed
32.
go back to reference Mclaughlin JR, Kreiger N, Sloan MP, Benson LN, Hilditch S, Clarke EA (1993) An historical cohort study of cardiac catheterization during childhood and the risk of cancer. Int J Epidemiol 22(4):584–591CrossRefPubMed Mclaughlin JR, Kreiger N, Sloan MP, Benson LN, Hilditch S, Clarke EA (1993) An historical cohort study of cardiac catheterization during childhood and the risk of cancer. Int J Epidemiol 22(4):584–591CrossRefPubMed
33.
go back to reference Modan B, Keinan L, Blumstein T, Sadetzki S (2000) Cancer following cardiac catheterization in childhood. Int J Epidemiol 29(3):424–428CrossRefPubMed Modan B, Keinan L, Blumstein T, Sadetzki S (2000) Cancer following cardiac catheterization in childhood. Int J Epidemiol 29(3):424–428CrossRefPubMed
34.
go back to reference Onnasch DGW, Schroder FK, Fischer G, Kramer HH (2007) Diagnostic reference levels and effective dose in paediatric cardiac catheterization. Br J Radiol 80(951):177–185CrossRefPubMed Onnasch DGW, Schroder FK, Fischer G, Kramer HH (2007) Diagnostic reference levels and effective dose in paediatric cardiac catheterization. Br J Radiol 80(951):177–185CrossRefPubMed
35.
go back to reference Pierce DA, Preston DL (2000) Radiation-related cancer risks at low doses among atomic bomb survivors. Radiat Res 154(2):178–186CrossRefPubMed Pierce DA, Preston DL (2000) Radiation-related cancer risks at low doses among atomic bomb survivors. Radiat Res 154(2):178–186CrossRefPubMed
36.
go back to reference Pierce DA, Shimizu Y, Preston DL, Vaeth M, Mabuchi K (1996) Studies of the mortality of atomic bomb survivors. Report 12, Part 1. Cancer: 1950–1990. Radiat Res 146(1):1–27CrossRefPubMed Pierce DA, Shimizu Y, Preston DL, Vaeth M, Mabuchi K (1996) Studies of the mortality of atomic bomb survivors. Report 12, Part 1. Cancer: 1950–1990. Radiat Res 146(1):1–27CrossRefPubMed
38.
go back to reference Rassow J, Schmaltz AA, Hentrich F, Streffer C (2000) Effective doses to patients from paediatric cardiac catheterization. Br J Radiol 73(866):172–183CrossRefPubMed Rassow J, Schmaltz AA, Hentrich F, Streffer C (2000) Effective doses to patients from paediatric cardiac catheterization. Br J Radiol 73(866):172–183CrossRefPubMed
39.
go back to reference Rogers DWO (2006) Fifty years of Monte Carlo simulations for medical physics. Phys Med Biol 51(13):R287–R301CrossRefPubMed Rogers DWO (2006) Fifty years of Monte Carlo simulations for medical physics. Phys Med Biol 51(13):R287–R301CrossRefPubMed
40.
go back to reference Sawdy JM, Kempton TM, Olshove V, Gocha M, Chisolm JL, Hill SL et al (2011) Use of a dose-dependent follow-up protocol and mechanisms to reduce patients and staff radiation exposure in congenital and structural interventions. Catheter Cardiovasc Interv 78(1):136–142CrossRefPubMed Sawdy JM, Kempton TM, Olshove V, Gocha M, Chisolm JL, Hill SL et al (2011) Use of a dose-dependent follow-up protocol and mechanisms to reduce patients and staff radiation exposure in congenital and structural interventions. Catheter Cardiovasc Interv 78(1):136–142CrossRefPubMed
41.
go back to reference Schueler BA, Julsrud PR, Gray JE, Stears JG, Wu KY (1994) Radiation exposure and efficacy of exposure-reduction techniques during cardiac catheterization in children. Am J Roentgenol 162(1):173–177CrossRef Schueler BA, Julsrud PR, Gray JE, Stears JG, Wu KY (1994) Radiation exposure and efficacy of exposure-reduction techniques during cardiac catheterization in children. Am J Roentgenol 162(1):173–177CrossRef
42.
go back to reference Sidhu MK, Goske MJ, Coley BJ, Connolly B, Racadio J, Yoshizumi TT et al (2009) Image gently, step lightly: increasing radiation dose awareness in pediatric interventions through an international social marketing campaign. J Vasc Interv Radiol 20(9):1115–1119CrossRefPubMed Sidhu MK, Goske MJ, Coley BJ, Connolly B, Racadio J, Yoshizumi TT et al (2009) Image gently, step lightly: increasing radiation dose awareness in pediatric interventions through an international social marketing campaign. J Vasc Interv Radiol 20(9):1115–1119CrossRefPubMed
43.
go back to reference Smith BG, Tibby SM, Qureshi SA, Rosenthal E, Krasemann T (2012) Quantification of temporal, procedural, and hardware-related factors influencing radiation exposure during pediatric cardiac catheterization. Catheter Cardiovasc Interv 80(6):931–936CrossRefPubMed Smith BG, Tibby SM, Qureshi SA, Rosenthal E, Krasemann T (2012) Quantification of temporal, procedural, and hardware-related factors influencing radiation exposure during pediatric cardiac catheterization. Catheter Cardiovasc Interv 80(6):931–936CrossRefPubMed
44.
go back to reference Spengler RF, Cook DH, Clarke EA, Olley PM, Newman AM (1983) Cancer mortality following cardiac catheterization: a preliminary follow-up study on 4,891 irradiated children. Pediatrics 71(2):235–239PubMed Spengler RF, Cook DH, Clarke EA, Olley PM, Newman AM (1983) Cancer mortality following cardiac catheterization: a preliminary follow-up study on 4,891 irradiated children. Pediatrics 71(2):235–239PubMed
45.
go back to reference Verghese GR, McElhinney DB, Strauss KJ, Bergersen L (2012) Characterization of radiation exposure and effect of a radiation monitoring policy in a large volume pediatric cardiac catheterization lab. Catheter Cardiovasc Interv 79(2):294–301CrossRefPubMed Verghese GR, McElhinney DB, Strauss KJ, Bergersen L (2012) Characterization of radiation exposure and effect of a radiation monitoring policy in a large volume pediatric cardiac catheterization lab. Catheter Cardiovasc Interv 79(2):294–301CrossRefPubMed
46.
go back to reference Wagner LK, Eifel PJ, Geise RA (1994) Potential biological effects following high X-ray dose interventional procedures. J Vasc Interv Radiol 5(1):71–84CrossRefPubMed Wagner LK, Eifel PJ, Geise RA (1994) Potential biological effects following high X-ray dose interventional procedures. J Vasc Interv Radiol 5(1):71–84CrossRefPubMed
47.
go back to reference Waldman JD, Rummerfield PS, Gilpin EA, Kirkpatrick SE (1981) Radiation exposure to the child during cardiac catheterization. Circulation 64(1):158–163CrossRefPubMed Waldman JD, Rummerfield PS, Gilpin EA, Kirkpatrick SE (1981) Radiation exposure to the child during cardiac catheterization. Circulation 64(1):158–163CrossRefPubMed
48.
go back to reference Yakoumakis E, Kostopoulou H, Makri T, Dimitriadis A, Georgiou E, Tsalafoutas I (2013) Estimation of radiation dose and risk to children undergoing cardiac catheterization for the treatment of a congenital heart disease using Monte Carlo simulations. Pediatr Radiol 43(3):339–346CrossRefPubMed Yakoumakis E, Kostopoulou H, Makri T, Dimitriadis A, Georgiou E, Tsalafoutas I (2013) Estimation of radiation dose and risk to children undergoing cardiac catheterization for the treatment of a congenital heart disease using Monte Carlo simulations. Pediatr Radiol 43(3):339–346CrossRefPubMed
Metadata
Title
Patient Radiation Exposure in a Modern, Large-Volume, Pediatric Cardiac Catheterization Laboratory
Authors
Andrew C. Glatz
Akash Patel
Xiaowei Zhu
Yoav Dori
Brian D. Hanna
Matthew J. Gillespie
Jonathan J. Rome
Publication date
01-06-2014
Publisher
Springer US
Published in
Pediatric Cardiology / Issue 5/2014
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-014-0869-7

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