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Published in:

01-05-2007 | Editorial

Targeting caspase-1 in sepsis: a novel approach to an old problem

Author: Gustavo Matute-Bello

Published in: Intensive Care Medicine | Issue 5/2007

Excerpt

More than 500,000 people develop sepsis each year in the USA alone, and approximately 175,000 of them die [1, 2]. Moreover, the incidence of sepsis has been increasing at an annualized rate of 8.7% [1]. Sepsis is one of the most common risk factors for acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS), accounting for 89% of all ALI/ARDS cases [3]. Approximately 30–50% of patients with ALI/ARDS who die have sepsis [4]. Understandably, the identification of small molecules that can be used as therapeutic agents in the treatment of sepsis has been a major research priority for the past several years. …

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Title: Targeting caspase-1 in sepsis: a novel approach to an old problem
Author: Gustavo Matute-Bello
Publication date: 01-05-2007
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 5/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-007-0589-z

ACC 2024 Congress

Springer Medicine

Targeting caspase-1 in sepsis: a novel approach to an old problem

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ACC 2024 Congress

Springer Medicine

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