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Intensive Care Medicine

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01-05-2007 | Brief Report

A pilot randomised controlled comparison of continuous veno–venous haemofiltration and extended daily dialysis with filtration: effect on small solutes and acid–base balance

Authors: Ian Baldwin, Toshio Naka, Bill Koch, Nigel Fealy, Rinaldo Bellomo

Published in: Intensive Care Medicine | Issue 5/2007

Abstract

Background and aims

Continuous veno–venous haemofiltration (CVVH) is an established treatment for acute renal failure (ARF). Recently, extended intermittent dialytic techniques have been proposed for the treatment of ARF. The aim of this study was to compare these two approaches.

Setting

Intensive care unit of tertiary hospital.

Subjects

Sixteen critically ill patients with ARF.

Design

Randomised controlled trial.

Intervention

We randomised sixteen patients to three consecutive days of treatment with either CVVH (8) or extended daily dialysis with filtration (EDDf) (8) and compared small-solute, electrolyte and acid–base control.

Results

There was no significant difference between the two therapies for urea or creatinine levels over 3 days. Of 80 electrolyte measurements taken before treatment, 19 were abnormal. All values were corrected as a result of treatment, except for one patient in the CVVH group who developed hypophosphataemia (0.54 mmol/l) at 72 h. After 3 days of treatment, there was a mild but persistent metabolic acidosis in the EDDf group compared to the CVVH group (median bicarbonate: 20 mmol/l vs. 29 mmol/l: p = 0.039; median base deficit: –4 mEq/l vs. –2.1 mEq/l, p = 0.033).

Conclusions

CVVH and EDDf as prescribed achieved similar control of urea, creatinine and electrolytes. Acidosis was better controlled with CVVH.

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Title: A pilot randomised controlled comparison of continuous veno–venous haemofiltration and extended daily dialysis with filtration: effect on small solutes and acid–base balance
Authors: Ian Baldwin
Toshio Naka
Bill Koch
Nigel Fealy
Rinaldo Bellomo
Publication date: 01-05-2007
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 5/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-007-0596-0

At a glance: The STEP trials

Springer Medicine

A pilot randomised controlled comparison of continuous veno–venous haemofiltration and extended daily dialysis with filtration: effect on small solutes and acid–base balance

Abstract

Background and aims

Setting

Subjects

Design

Intervention

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background and aims

Setting

Subjects

Design

Intervention

Results

Conclusions

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