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Journal of Endocrinological Investigation

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01-05-2022 | Thyrotoxicosis | Rapid Communication

Thyrotoxicosis following SARS-COV-2 vaccination: a case series and discussion

Authors: B. Pla Peris, A. Á. Merchante Alfaro, F. J. Maravall Royo, P. Abellán Galiana, S. Pérez Naranjo, M. González Boillos

Published in: Journal of Endocrinological Investigation | Issue 5/2022

Abstract

Aim

To describe a case series of thyrotoxicosis likely triggered by SARS-CoV-2 vaccination and to warn physicians about this potential correlation. To report clinical, laboratory and imaging findings and provide further information that goes in line with the underlying mechanisms.

Methods

Single-center case series based on all the information collected in the hospital medical records, as well as the temporal sequence between the onset of symptoms and COVID-19 vaccination.

Results

We report 8 cases with thyrotoxicosis after SARS-CoV-2 vaccination. 4 cases of Graves’ disease (GD), 2 cases of subacute painful thyroiditis (SAT), 1 case of concurrent GD and SAT and 1 case of atypical subacute thyroiditis. Five patients received BNT162b2 mRNA vaccine, 3 patients 1273 mRNA vaccine. The onset of symptoms following vaccination ranged from 10 to 14 days in six of eight patients and from 7 to 8 weeks in two patients.

Conclusions

Several hypotheses have been proposed to explain the potential correlation between SARS-CoV-2 vaccination and thyrotoxicosis, including immune system hyper-stimulation, molecular mimicry and Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA). We should pay greater attention to thyroid disorders in patients receiving vaccine against SARS-CoV-2.

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Title: Thyrotoxicosis following SARS-COV-2 vaccination: a case series and discussion
Authors: B. Pla Peris
A. Á. Merchante Alfaro
F. J. Maravall Royo
P. Abellán Galiana
S. Pérez Naranjo
M. González Boillos
Publication date: 01-05-2022
Publisher: Springer International Publishing
Keywords: Thyrotoxicosis
SARS-CoV-2
Vaccination
Thyroiditis
Subacute Granulomatous Thyroiditis
Neck Pain
COVID-19 Vaccination
Published in: Journal of Endocrinological Investigation / Issue 5/2022
Electronic ISSN: 1720-8386
DOI: https://doi.org/10.1007/s40618-022-01739-0

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