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Current Nutrition Reports
Published in: Current Nutrition Reports 1/2015

01-03-2015 | Cancer (MF Leitzmann, Section Editor)

Dietary Risk Reduction Factors for the Barrett’s Esophagus-Esophageal Adenocarcinoma Continuum: A Review of the Recent Literature

Authors: Jessica L. Petrick, Nan Li, Kathleen M. McClain, Susan E. Steck, Marilie D. Gammon

Published in: Current Nutrition Reports | Issue 1/2015

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Abstract

Esophageal adenocarcinoma (EA) incidence is among the most rapidly increasing of any cancer type in the U.S., and prognosis is poor. Prevalence of the potential precursor lesion, Barrett’s esophagus (BE), is also increasing. Candidates for safe and effective risk reduction strategies are needed, potentially including dietary components. In this qualitative review, we summarize recently published epidemiologic studies, in context of earlier work, on dietary intake and BE-EA outcomes. Potential cohort study/intervention trial candidates which could be increased to reduce BE-EA development include intake of: (1) fruits and vegetables; vegetables; fruit (EA only); (2) β-carotene and vitamins C and E; (3) folate (EA only); and (4) total fiber (EA only). Also, (5) red and processed meat intake could be targeted for dietary reduction/omission to reduce EA development. Few dietary constituents have been evaluated among EA patients to examine associations with mortality, thus interventions conducted among EA patients are premature.
Literature
1.
Simard EP, Ward EM, Siegel R, Jemal A. Cancers with increasing incidence trends in the United States: 1999 through 2008. CA Cancer J Clin. 2012;62(2):118–28.PubMedCrossRef
2.
Trivers KF, De Roos AJ, Gammon MD, Vaughan TL, Risch HA, Olshan AF, et al. Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers. Clin Gastroenterol Hepatol. 2005;3(3):225–30.PubMedCrossRef
3.
Crane SJ, Locke 3rd GR, Harmsen WS, Zinsmeister AR, Romero Y, Talley NJ. Survival trends in patients with gastric and esophageal adenocarcinomas: a population-based study. Mayo Clin Proc. 2008;83(10):1087–94.PubMedCentralPubMedCrossRef
4.
Shaheen N, Ransohoff DF. Gastroesophageal reflux, barrett esophagus, and esophageal cancer: scientific review. JAMA. 2002;287(15):1972–81.PubMedCrossRef
5.
Riddell RH. The genesis of Barrett esophagus: has a histologic transition from gastroesophageal reflux disease-damaged epithelium to columnar metaplasia ever been seen in humans? Arch Pathol Lab Med. 2005;129(2):164–9.PubMed
6.
Sharma P, McQuaid K, Dent J, Fennerty MB, Sampliner R, Spechler S, et al. A critical review of the diagnosis and management of Barrett’s esophagus: the AGA Chicago Workshop. Gastroenterology. 2004;127(1):310–30.PubMedCrossRef
7.
Mawhinney MR, Glasgow RE. Current treatment options for the management of esophageal cancer. Cancer Manag Res. 2012;4:367–77.PubMedCentralPubMed
8.
Falk GW. Risk factors for esophageal cancer development. Surg Oncol Clin N Am. 2009;18(3):469–85.PubMedCrossRef
9.
Agaku IT, King BA, Dube SR, Centers for Disease C, Prevention. Current cigarette smoking among adults—United States, 2005–2012. MMWR Morb Mortal Wkly Rep. 2014;63(2):29–34.PubMed
10.
Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766–81.PubMedCrossRef
11.
Sarlio-Lahteenkorva S, Rissanen A, Kaprio J. A descriptive study of weight loss maintenance: 6 and 15 year follow-up of initially overweight adults. Int J Obes Relat Metab Disord. 2000;24(1):116–25.PubMedCrossRef
12.
Corley DA, Buffler PA. Oesophageal and gastric cardia adenocarcinomas: analysis of regional variation using the Cancer Incidence in Five Continents database. Int J Epidemiol. 2001;30(6):1415–25.PubMedCrossRef
13.
Schottenfeld D, Fraumeni JF. Cancer epidemiology and prevention. 3rd ed. Oxford: Oxford University Press; 2006.CrossRef
14.
Kamineni A, Williams MA, Schwartz SM, Cook LS, Weiss NS. The incidence of gastric carcinoma in Asian migrants to the United States and their descendants. Cancer Causes Control. 1999;10(1):77–83.PubMedCrossRef
15.
Lee J, Demissie K, Lu SE, Rhoads GG. Cancer incidence among Korean-American immigrants in the United States and native Koreans in South Korea. Cancer Control. 2007;14(1):78–85.PubMed
16.
Devesa SS, Blot WJ, Fraumeni Jr JF. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer. 1998;83(10):2049–53.PubMedCrossRef
17.
Tzonou A, Lipworth L, Garidou A, Signorello LB, Lagiou P, Hsieh C, et al. Diet and risk of esophageal cancer by histologic type in a low-risk population. Int J Cancer. 1996;68(3):300–4.PubMedCrossRef
18.
Kubo A, Corley DA, Jensen CD, Kaur R. Dietary factors and the risks of oesophageal adenocarcinoma and Barrett's oesophagus. Nutr Res Rev. 2010;23(2):230–46.PubMedCentralPubMedCrossRef
19.
Pohl H, Wrobel K, Bojarski C, Voderholzer W, Sonnenberg A, Rosch T, et al. Risk factors in the development of esophageal adenocarcinoma. Am J Gastroenterol. 2013;108(2):200–7.PubMedCrossRef
20.•
Ibiebele TI, Hughes MC, Nagle CM, Bain CJ, Whiteman DC, Webb PM, et al. Dietary antioxidants and risk of Barrett's esophagus and adenocarcinoma of the esophagus in an Australian population. Int J Cancer. 2013;133(1):214–24. This is the first study to examine the association between dietary antioxidants and BE, accounting for dysplastic versus nondysplastic BE.PubMedCrossRef
21.•
Li B, Jiang G, Zhang G, Xue Q, Zhang H, Wang C, et al. Intake of vegetables and fruit and risk of esophageal adenocarcinoma: a meta-analysis of observational studies. Eur J Nutr. 2014;53(7):1511–21. This recent meta-analysis provides the most current synthesis of the literature regarding fruit and vegetable intake and EA, suggesting a 32 % decreased risk of EA with high intakes of fruits and vegetables.PubMedCrossRef
22.
Ibiebele TI, Hughes MC, Whiteman DC, Webb PM, Australian Cancer S. Dietary patterns and risk of oesophageal cancers: a population-based case-control study. Br J Nutr. 2012;107(8):1207–16.PubMedCrossRef
23.
Jeurnink SM, Buchner FL, Bueno-de-Mesquita HB, Siersema PD, Boshuizen HC, Numans ME, et al. Variety in vegetable and fruit consumption and the risk of gastric and esophageal cancer in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2012;131(6):E963–73.PubMedCrossRef
24.••
Jiao L, Kramer JR, Rugge M, Parente P, Verstovsek G, Alsarraj A, et al. Dietary intake of vegetables, folate, and antioxidants and the risk of Barrett's esophagus. Cancer Causes Control. 2013;24(5):1005–14. This is the first epidemiologic study to consider the association between isoflavones and BE, suggesting a 55 % decreased risk of BE associated with high intake of isoflavones.PubMedCentralPubMedCrossRef
25.
Keszei AP, Schouten LJ, Driessen AL, Huysentruyt CJ, Keulemans YC, Goldbohm RA, et al. Vegetable, fruit and nitrate intake in relation to the risk of Barrett's oesophagus in a large Dutch cohort. Br J Nutr. 2014;111(8):1452–62.PubMedCrossRef
26.
Navarro Silvera SA, Mayne ST, Gammon MD, Vaughan TL, Chow WH, Dubin JA, et al. Diet and lifestyle factors and risk of subtypes of esophageal and gastric cancers: classification tree analysis. Ann Epidemiol. 2014;24(1):50–7.PubMedCentralPubMedCrossRef
27.
Kubo A, Levin TR, Block G, Rumore GJ, Quesenberry Jr CP, Buffler P, et al. Dietary antioxidants, fruits, and vegetables and the risk of Barrett's esophagus. Am J Gastroenterol. 2008;103(7):1614–23.PubMedCentralPubMedCrossRef
28.
Murphy SJ, Anderson LA, Ferguson HR, Johnston BT, Watson PR, McGuigan J, et al. Dietary antioxidant and mineral intake in humans is associated with reduced risk of esophageal adenocarcinoma but not reflux esophagitis or Barrett's esophagus. J Nutr. 2010;140(10):1757–63.PubMedCrossRef
29.
Fountoulakis A, Martin IG, White KL, Dixon MF, Cade JE, Sue-Ling HM, et al. Plasma and esophageal mucosal levels of vitamin C: role in the pathogenesis and neoplastic progression of Barrett's esophagus. Dig Dis Sci. 2004;49(6):914–9.PubMedCrossRef
30.
Ge XX, Xing MY, Yu LF, Shen P. Carotenoid intake and esophageal cancer risk: a meta-analysis. Asian Pac J Cancer Prev. 2013;14(3):1911–8.PubMedCrossRef
31.
Kubo A, Corley DA. Meta-analysis of antioxidant intake and the risk of esophageal and gastric cardia adenocarcinoma. Am J Gastroenterol. 2007;102(10):2323–30.PubMedCrossRef
32.
Sharp L, Carsin AE, Cantwell MM, Anderson LA, Murray LJ, Group FS. Intakes of dietary folate and other B vitamins are associated with risks of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis. J Nutr. 2013;143(12):1966–73.PubMedCrossRef
33.
Ekiz F, Ormeci N, Coban S, Karabulut HG, Aktas B, Tukun A, et al. Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis. Dis Esophagus. 2012;25(5):437–41.PubMedCrossRef
34.
Xiao Q, Freedman ND, Ren J, Hollenbeck AR, Abnet CC, Park Y. Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study. Br J Cancer. 2014;110(5):1328–33.PubMedCrossRef
35.
Steevens J, Schouten LJ, Driessen AL, Huysentruyt CJ, Keulemans YC, Goldbohm RA, et al. Toenail selenium status and the risk of Barrett's esophagus: the Netherlands Cohort Study. Cancer Causes Control. 2010;21(12):2259–68.PubMedCentralPubMedCrossRef
36.
O'Rorke MA, Cantwell MM, Abnet CC, Brockman AJ, Murray LJ, Group FS. Toenail trace element status and risk of Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study. Int J Cancer. 2012;131(8):1882–91.PubMedCentralPubMedCrossRef
37.
Moe GL, Kristal AR, Levine DS, Vaughan TL, Reid BJ. Waist-to-hip ratio, weight gain, and dietary and serum selenium are associated with DNA content flow cytometry in Barrett's esophagus. Nutr Cancer. 2000;36(1):7–13.PubMedCrossRef
38.
Steevens J, van den Brandt PA, Goldbohm RA, Schouten LJ. Selenium status and the risk of esophageal and gastric cancer subtypes: the Netherlands cohort study. Gastroenterology. 2010;138(5):1704–13.PubMedCrossRef
39.
Takata Y, Kristal AR, Santella RM, King IB, Duggan DJ, Lampe JW, et al. Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants. PLoS One. 2012;7(6):e38612.PubMedCentralPubMedCrossRef
40.••
Dawsey SP, Hollenbeck A, Schatzkin A, Abnet CC. A prospective study of vitamin and mineral supplement use and the risk of upper gastrointestinal cancers. PLoS One. 2014;9(2):e88774. This study is the largest study to date to examine the use of vitamins in association with EA, suggesting a 25 % decreased risk of EA associated with daily intake of multivitamin supplements.PubMedCentralPubMedCrossRef
41.
Dong LM, Kristal AR, Peters U, Schenk JM, Sanchez CA, Rabinovitch PS, et al. Dietary supplement use and risk of neoplastic progression in esophageal adenocarcinoma: a prospective study. Nutr Cancer. 2008;60(1):39–48.PubMedCentralPubMedCrossRef
42.
Dutta SK, Agrawal K, Girotra M, Fleisher AS, Motevalli M, Mah'moud MA, et al. Barrett's esophagus and beta-carotene therapy: symptomatic improvement in GERD and enhanced HSP70 expression in esophageal mucosa. Asian Pac J Cancer Prev. 2012;13(12):6011–6.PubMedCrossRef
43.
Petrick J, Steck S, Bradshaw P, Engel L, He K, Vaughan T, et al. Dietary flavonoid intake and risk of Barrett’s esophagus. Am J Epidemiol. 2013;177(11 Suppl):L02.
44.
Bobe G, Peterson JJ, Gridley G, Hyer M, Dwyer JT, Brown LM. Flavonoid consumption and esophageal cancer among black and white men in the United States. Int J Cancer. 2009;125(5):1147–54.PubMedCrossRef
45.••
Lin Y, Yngve A, Lagergren J, Lu Y. Dietary intake of lignans and risk of adenocarcinoma of the esophagus and gastroesophageal junction. Cancer Causes Control. 2012;23(6):837–44. This is the only epidemiologic study to date to consider the association between lignan intake and EA, suggesting a 35 % decreased risk of EA associated with high lignan intake.PubMedCrossRef
46.
Petrick J, Steck S, Bradshaw P, Chow W, Engel L, He K et al. Dietary flavonoid intake and risk of esophageal and gastric cancers (abstract). 2013 American Institute for Cancer Research Annual Research Conference on Food, Nutrition, Physical Activity and Cancer: Bethesda; 2013.
47.
Vermeulen E, Zamora-Ros R, Duell EJ, Lujan-Barroso L, Boeing H, Aleksandrova K, et al. Dietary flavonoid intake and esophageal cancer risk in the European prospective investigation into cancer and nutrition cohort. Am J Epidemiol. 2013;178(4):570–81.PubMedCrossRef
48.
Kresty LA, Frankel WL, Hammond CD, Baird ME, Mele JM, Stoner GD, et al. Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients. Nutr Cancer. 2006;54(1):148–56.PubMedCrossRef
49.••
Coleman HG, Murray LJ, Hicks B, Bhat SK, Kubo A, Corley DA, et al. Dietary fiber and the risk of precancerous lesions and cancer of the esophagus: a systematic review and meta-analysis. Nutr Rev. 2013;71(7):474–82. This systematic review and meta-analysis provides the most current evidence for the association between fiber intake (including total, fruit, vegetable, and cereal fiber types) and BE-EA, suggesting a 34 % decreased risk of EA associated with high levels of total fiber intake.PubMedCrossRef
50.
Kubo A, Block G, Quesenberry Jr CP, Buffler P, Corley DA. Effects of dietary fiber, fats, and meat intakes on the risk of Barrett's esophagus. Nutr Cancer. 2009;61(5):607–16.PubMedCentralPubMedCrossRef
51.
Mulholland HG, Cantwell MM, Anderson LA, Johnston BT, Watson RG, Murphy SJ, et al. Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Cancer Causes Control. 2009;20(3):279–88.PubMedCrossRef
52.
Tasevska N, Jiao L, Cross AJ, Kipnis V, Subar AF, Hollenbeck A, et al. Sugars in diet and risk of cancer in the NIH-AARP Diet and Health Study. Int J Cancer. 2012;130(1):159–69.PubMedCentralPubMedCrossRef
53.
Chen H, Ward MH, Graubard BI, Heineman EF, Markin RM, Potischman NA, et al. Dietary patterns and adenocarcinoma of the esophagus and distal stomach. Am J Clin Nutr. 2002;75(1):137–44.PubMed
54.
O'Doherty MG, Cantwell MM, Murray LJ, Anderson LA, Abnet CC, Group FS. Dietary fat and meat intakes and risk of reflux esophagitis, Barrett's esophagus and esophageal adenocarcinoma. Int J Cancer. 2011;129(6):1493–502.PubMedCentralPubMedCrossRef
55.
Jiao L, Kramer JR, Chen L, Rugge M, Parente P, Verstovsek G, et al. Dietary consumption of meat, fat, animal products and advanced glycation end-products and the risk of Barrett's oesophagus. Aliment Pharmacol Ther. 2013;38(7):817–24.PubMedCrossRef
56.
Keszei AP, Schouten LJ, Driessen AL, Huysentruyt CJ, Keulemans YC, van den Brandt PA. Meat consumption and the risk of Barrett's esophagus in a large Dutch cohort. Cancer Epidemiol Biomarkers Prev. 2013;22(6):1162–6.PubMedCrossRef
57.•
Salehi M, Moradi-Lakeh M, Salehi MH, Nojomi M, Kolahdooz F. Meat, fish, and esophageal cancer risk: a systematic review and dose-response meta-analysis. Nutr Rev. 2013;71(5):257–67. This is the most recent meta-analysis to examine all types of meat (including total, red, poultry, and processed meats) in association with EA, suggesting little or no association between EA risk and total meat or poultry and 19-37 % increased EA risk assocoiated with red and processed meats.PubMedCrossRef
58.
Keszei AP, Schouten LJ, Goldbohm RA, van den Brandt PA. Red and processed meat consumption and the risk of esophageal and gastric cancer subtypes in The Netherlands Cohort Study. Ann Oncol. 2012;23(9):2319–26.PubMedCrossRef
59.
Jiang G, Li B, Liao X, Zhong C. Poultry and fish intake and risk of esophageal cancer: A meta-analysis of observational studies. Asia Pac J Clin Oncol. 2013.
60.
Corley DA, Kubo A, Levin TR, Habel L, Zhao W, Leighton P, et al. Iron intake and body iron stores as risk factors for Barrett's esophagus: a community-based study. Am J Gastroenterol. 2008;103(12):2997–3004.PubMedCentralPubMedCrossRef
61.
O'Doherty MG, Abnet CC, Murray LJ, Woodside JV, Anderson LA, Brockman JD, et al. Iron intake and markers of iron status and risk of Barrett's esophagus and esophageal adenocarcinoma. Cancer Causes Control. 2010;21(12):2269–79.PubMedCentralPubMedCrossRef
62.
Cross AJ, Freedman ND, Ren J, Ward MH, Hollenbeck AR, Schatzkin A, et al. Meat consumption and risk of esophageal and gastric cancer in a large prospective study. Am J Gastroenterol. 2011;106(3):432–42.PubMedCentralPubMedCrossRef
63.
Jakszyn P, Lujan-Barroso L, Agudo A, Bueno-de-Mesquita HB, Molina E, Sanchez MJ, et al. Meat and heme iron intake and esophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study. Int J Cancer. 2013;133(11):2744–50.PubMed
64.
Ward MH, Cross AJ, Abnet CC, Sinha R, Markin RS, Weisenburger DD. Heme iron from meat and risk of adenocarcinoma of the esophagus and stomach. Eur J Cancer Prev. 2012;21(2):134–8.PubMedCentralPubMedCrossRef
65.
Keszei AP, Goldbohm RA, Schouten LJ, Jakszyn P, van den Brandt PA. Dietary N-nitroso compounds, endogenous nitrosation, and the risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study. Am J Clin Nutr. 2013;97(1):135–46.PubMedCrossRef
66.•
Han YJ, Li J, Huang W, Fang Y, Xiao LN, Liao ZE. Fish consumption and risk of esophageal cancer and its subtypes: a systematic review and meta-analysis of observational studies. Eur J Clin Nutr. 2013;67(2):147–54. This meta-analysis provides the most complete and up-to-date synthesis of the literature on the association between fish consumption and EA, but is unable to distinguish cooking methods used in preparation that could influence this association.PubMedCrossRef
67.••
O'Doherty MG, Freedman ND, Hollenbeck AR, Schatzkin A, Murray LJ, Cantwell MM, et al. Association of dietary fat intakes with risk of esophageal and gastric cancer in the NIH-AARP diet and health study. Int J Cancer. 2012;131(6):1376–87. This is the first epidemiologic study to consider a specific type of polyunsaturatted fatty acids (i.e., omega-3) and EA, suggesting little or no association.PubMedCentralPubMedCrossRef
68.
Bravi F, Edefonti V, Randi G, Ferraroni M, La Vecchia C, Decarli A. Dietary patterns and upper aerodigestive tract cancers: an overview and review. Ann Oncol. 2012;23(12):3024–39.PubMedCrossRef
69.
Kubo A, Levin TR, Block G, Rumore GJ, Quesenberry Jr CP, Buffler P, et al. Dietary patterns and the risk of Barrett's esophagus. Am J Epidemiol. 2008;167(7):839–46.PubMedCrossRef
70.
Hu FB. Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol. 2002;13(1):3–9.PubMedCrossRef
71.
Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc. 1996;96(10):1027–39.PubMedCrossRef
72.
Watzl B. Anti-inflammatory effects of plant-based foods and of their constituents. Int J Vitam Nutr Res. 2008;78(6):293–8.PubMedCrossRef
73.
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006;160(1):1–40.PubMedCrossRef
74.
Pierini R, Kroon PA, Guyot S, Ivory K, Johnson IT, Belshaw NJ. Procyanidin effects on oesophageal adenocarcinoma cells strongly depend on flavan-3-ol degree of polymerization. Mol Nutr Food Res. 2008;52(12):1399–407.PubMedCrossRef
75.
Lee LT, Huang YT, Hwang JJ, Lee AY, Ke FC, Huang CJ, et al. Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells. Biochem Pharmacol. 2004;67(11):2103–14.PubMedCrossRef
76.
Aiyer HS, Li Y, Losso JN, Gao C, Schiffman SC, Slone SP, et al. Effect of freeze-dried berries on the development of reflux-induced esophageal adenocarcinoma. Nutr Cancer. 2011;63(8):1256–62.PubMedCrossRef
77.
Song S, Krishnan K, Liu K, Bresalier RS. Polyphenon E inhibits the growth of human Barrett's and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expression. Clin Cancer Res. 2009;15(2):622–31.PubMedCentralPubMedCrossRef
78.
Lechpammer M, Xu X, Ellis FH, Bhattacharaya N, Shapiro GI, Loda M. Flavopiridol reduces malignant transformation of the esophageal mucosa in p27 knockout mice. Oncogene. 2005;24(10):1683–8.PubMedCrossRef
79.
Slavin JL. Mechanisms for the impact of whole grain foods on cancer risk. J Am Coll Nutr. 2000;19(3 Suppl):300S–7S.PubMedCrossRef
80.
Kaaks R, Lukanova A. Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc. 2001;60(1):91–106.PubMedCrossRef
81.
Greer KB, Thompson CL, Brenner L, Bednarchik B, Dawson D, Willis J, et al. Association of insulin and insulin-like growth factors with Barrett's oesophagus. Gut. 2012;61(5):665–72.PubMedCentralPubMedCrossRef
82.
Ryan AM, Healy LA, Power DG, Byrne M, Murphy S, Byrne PJ, et al. Barrett esophagus: prevalence of central adiposity, metabolic syndrome, and a proinflammatory state. Ann Surg. 2008;247(6):909–15.PubMedCrossRef
83.
Duggan C, Onstad L, Hardikar S, Blount PL, Reid BJ, Vaughan TL. Association between markers of obesity and progression from Barrett's esophagus to esophageal adenocarcinoma. Clin Gastroenterol Hepatol. 2013;11(8):934–43.PubMedCentralPubMedCrossRef
84.
Barton JC, Acton RT, Dawkins FW, Adams PC, Lovato L, Leiendecker-Foster C, et al. Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in whites and blacks in the Hemochromatosis and Iron Overload Screening Study. Genet Test. 2005;9(3):231–41.PubMedCrossRef
85.
Beutler E, West C. Hematologic differences between African-Americans and whites: the roles of iron deficiency and alpha-thalassemia on hemoglobin levels and mean corpuscular volume. Blood. 2005;106(2):740–5.PubMedCentralPubMedCrossRef
86.
Wang W, Zhu J, Lyu F, Panigrahy D, Ferrara KW, Hammock B et al. omega-3 Polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer. Prostaglandins Other Lipid Mediat. 2014.
87.
Pauwels EK, Kairemo K. Fatty acid facts, part II: role in the prevention of carcinogenesis, or, more fish on the dish? Drug News Perspect. 2008;21(9):504–10.PubMedCrossRef
Metadata
Title
Dietary Risk Reduction Factors for the Barrett’s Esophagus-Esophageal Adenocarcinoma Continuum: A Review of the Recent Literature
Authors
Jessica L. Petrick
Nan Li
Kathleen M. McClain
Susan E. Steck
Marilie D. Gammon
Publication date
01-03-2015
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 1/2015
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-014-0108-0

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