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01-04-2009 | Original Paper

Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett’s esophagus, and esophageal adenocarcinoma

Authors: Helen G. Mulholland, Marie M. Cantwell, Lesley A. Anderson, Brian T. Johnston, R. G. Peter Watson, Seamus J. Murphy, Heather R. Ferguson, Jim McGuigan, John V. Reynolds, Harry Comber, Liam J. Murray

Published in: Cancer Causes & Control | Issue 3/2009

Abstract

Objective

To examine the association between dietary glycemic index (GI), glycemic load (GL), total carbohydrate, sugars, starch, and fiber intakes and the risk of reflux esophagitis, Barrett’s esophagus, and esophageal adenocarcinoma.

Methods

In an all-Ireland study, dietary information was collected from patients with esophageal adenocarcinoma (n = 224), long-segment Barrett’s esophagus (n = 220), reflux esophagitis (n = 219), and population-based controls (n = 256). Multiple logistic regression analysis examined the association between dietary variables and disease risk by tertiles of intake and as continuous variables, while adjusting for potential confounders.

Results

Reflux esophagitis risk was positively associated with starch intake and negatively associated with sugar intake. Barrett’s esophagus risk was significantly reduced in people in the highest versus the lowest tertile of fiber intake (OR 0.44 95%CI 0.25–0.80). Fiber intake was also associated with a reduced risk of esophageal adenocarcinoma, as was total carbohydrate intake (OR 0.45 95%CI 0.33–0.61 per 50 g/d increase). However, an increased esophageal adenocarcinoma risk was detected per 10 unit increase in GI intake (OR 1.42 95%CI 1.07–1.89).

Conclusions

Our findings suggest that fiber intake is inversely associated with Barrett’s esophagus and esophageal adenocarcinoma risk. Esophageal adenocarcinoma risk is inversely associated with total carbohydrate consumption but positively associated with high GI intakes.

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Title: Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett’s esophagus, and esophageal adenocarcinoma
Authors: Helen G. Mulholland
Marie M. Cantwell
Lesley A. Anderson
Brian T. Johnston
R. G. Peter Watson
Seamus J. Murphy
Heather R. Ferguson
Jim McGuigan
John V. Reynolds
Harry Comber
Liam J. Murray
Publication date: 01-04-2009
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 3/2009
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-008-9242-6

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