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Journal of Cardiovascular Translational Research

Published in:

01-02-2020 | Hypertension | Review

Gender Differences in Hypertension

Authors: Juan-Juan Song, Zheng Ma, Juan Wang, Lin-Xi Chen, Jiu-Chang Zhong

Published in: Journal of Cardiovascular Translational Research | Issue 1/2020

Abstract

Hypertension is the leading risk factor for global mortality and morbidity and remains the major preventable cause of cardiovascular diseases. Gender differences in risk factors and awareness, treatment, and control of hypertension have been well established in humans. There are significant differences in epidemiology and clinical characteristic of hypertension between men and women. Moreover, gender differences are linked with several specific types of hypertension, including postmenopausal hypertension, white coat hypertension, masked hypertension, and hypertensive disorders of pregnancy. Gender differences have been implicated in the prevalence and determinants of hypertension and prehypertension whereas the control rate is similar between men and women taking antihypertensive medication. Importantly, distinct roles of the angiotensin-converting enzyme 2/Apelin signaling, sex hormone, endothelin-1, and sympathetic nervous activity contribute to sex differences in blood pressure control. This review summarizes gender differences in clinical features and determinants of hypertension and the underlying mechanisms responsible for hypertension.

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Title: Gender Differences in Hypertension
Authors: Juan-Juan Song
Zheng Ma
Juan Wang
Lin-Xi Chen
Jiu-Chang Zhong
Publication date: 01-02-2020
Publisher: Springer US
Keywords: Hypertension
Hypertension
Published in: Journal of Cardiovascular Translational Research / Issue 1/2020
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-019-09888-z

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