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Current Rheumatology Reports
Published in: Current Rheumatology Reports 7/2021

01-07-2021 | Systemic Lupus Erythematosus | Systemic Lupus Erythematosus (G Tsokos, Section Editor)

Updates on Clinical Trials in Systemic Lupus Erythematosus

Author: Amir Sharabi

Published in: Current Rheumatology Reports | Issue 7/2021

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Abstract

Purpose of Review

Because of the complexity of systemic lupus erythematosus (SLE), different approaches are undertaken while investigating potential therapeutic compounds to treat the disease. The purpose of this review is to summarize the results from recent clinical trials, which investigated different compounds for treating SLE.

Recent Findings

Targeting B cells and type I interferons constitutes the major focus in recent clinical trials. The potential for therapeutic effects of small molecule inhibition such as JAK, Tyk, and Btk is now being investigated for treating SLE. The immunoregulation of T cell activation in SLE is studied using low-dose IL-2 and CD40 ligand inhibition. There are clinical trials that study bispecific antibodies, with binding specificities for 2 different target molecules related to T- and B-cell activation or to different aspects of B cell activation. An approach of combination treatment is also being studied.

Summary

Clinical trials are underway and new treatment compounds for SLE are being anticipated.
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Metadata
Title
Updates on Clinical Trials in Systemic Lupus Erythematosus
Author
Amir Sharabi
Publication date
01-07-2021
Publisher
Springer US
Published in
Current Rheumatology Reports / Issue 7/2021
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-021-01014-w

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