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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 6/2012

01-06-2012 | Review Article

Current Strategies and Future Perspectives for Intraperitoneal Adhesion Prevention

Authors: Christoph Brochhausen, Volker H. Schmitt, Constanze N. E. Planck, Taufiek K. Rajab, David Hollemann, Christine Tapprich, Bernhard Krämer, Christian Wallwiener, Helmut Hierlemann, Rolf Zehbe, Heinrich Planck, C. James Kirkpatrick

Published in: Journal of Gastrointestinal Surgery | Issue 6/2012

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Abstract

Introduction

The formation of peritoneal adhesions still is a relevant clinical problem after abdominal surgery. Until today, the most important clinical strategies for adhesion prevention are accurate surgical technique and the physical separation of traumatized serosal areas. Despite a variety of barriers which are available in clinical use, the optimal material has not yet been found.

Discussion

Mesothelial cells play a crucial physiological role in frictionless gliding of the serosa and the maintenance of an antiadhesive surface. The formation of postoperative adhesions results from a cascade of events and is regulated by various cellular and humoral factors. Therefore, optimization or functionalization of barrier materials by developments interacting with this cascade on a structural or pharmacological level could give an innovative input for future strategies in peritoneal adhesion prevention. For this purpose, the proper understanding of the formal pathogenesis of adhesion formation is essential. Based on the physiology of the serosa and the pathophysiology of adhesion formation, the available barriers in current clinical practice as well as new innovations are discussed in the present review.
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Metadata
Title
Current Strategies and Future Perspectives for Intraperitoneal Adhesion Prevention
Authors
Christoph Brochhausen
Volker H. Schmitt
Constanze N. E. Planck
Taufiek K. Rajab
David Hollemann
Christine Tapprich
Bernhard Krämer
Christian Wallwiener
Helmut Hierlemann
Rolf Zehbe
Heinrich Planck
C. James Kirkpatrick
Publication date
01-06-2012
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 6/2012
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-011-1819-9

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