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International Ophthalmology
Published in: International Ophthalmology 1/2024

01-12-2024 | Rheumatoid Arthritis | Original Paper

Choroidal, retinal, and optic nerve changes in rheumatoid arthritis and primary sjogren’s syndrome patients: comparıson with each other and healthy subjects

Authors: Pelin Kiyat, Omer Karti, Önay Gercik, Tuncer Şak

Published in: International Ophthalmology | Issue 1/2024

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Abstract

Purpose

The present study aims to evaluate the optic nerve, macula, and choroidal changes in both rheumatoid arthritis (RA) and primary Sjögren’s syndrome (SjS) patients, and to compare these findings with age-matched healthy volunteers.

Methods

This study included 46 RA patients, 33 primary SjS patients, and 37 age-matched healthy volunteers. All of the patients underwent a thorough ophthalmological examination, during which measurements of the retinal nerve fiber layer (RNFL), ganglion cell layer(GCL), and subfoveal choroidal thickness (CT) were taken using OCT (optical coherence tomography). The measurements taken from the right eye of each patient were used to compare among the groups.

Results

RNFL thickness in superior quadrant was found to be statistically significantly thinner in the eyes with RA when compared to the control group (p = 0.022). In the nasal quadrant, the RNFL thickness was significantly thinner in patients with primary SjS compared to healthy individuals (p = 0.036). Also, the temporal quadrant RNFL was significantly thinner in RA patients than in the primary SjS patients (p = 0.033). GCL thickness was observed to be thinner in all quadrants of both RA and primary SjS groups compared to the control group. However, the difference was not found to be statistically significant. Subfoveal CT was observed to be thicker in RA and SjS groups compared to the control group, but this difference was also not statistically significant.

Conclusion

Systemic autoimmune diseases like RA and primary SjS can lead to a decrease in RNLF and GCL thickness, which can impair visual acuity even in the absence of ocular symptoms. Therefore, monitoring changes in the optic nerve, retina, and choroid layer are crucial in these patients.
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Metadata
Title
Choroidal, retinal, and optic nerve changes in rheumatoid arthritis and primary sjogren’s syndrome patients: comparıson with each other and healthy subjects
Authors
Pelin Kiyat
Omer Karti
Önay Gercik
Tuncer Şak
Publication date
01-12-2024
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-024-02970-9

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