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Published in: International Ophthalmology 5/2018

01-10-2018 | Original Paper

Evaluation of retrobulbar blood flow and choroidal thickness in patients with rheumatoid arthritis

Authors: Ali Kal, Enes Duman, Almila Sarıgül Sezenöz, Mahmut Oğuz Ulusoy, Öznur Kal

Published in: International Ophthalmology | Issue 5/2018

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Abstract

Purpose

To evaluate whether retrobulbar blood flow and choroidal thickness (CT) are affected in patients with rheumatoid arthritis (RA), and the relationship between these values.

Methods

We evaluated 40 eyes of 20 RA patients and 40 eyes of 20 healthy controls. The enhanced depth imaging optical coherence tomography, color Doppler imaging, was held. Statistical analysis was performed.

Results

Peak systolic velocity (PSV) of ophthalmic (OA) and central retinal artery (CRA) were significantly higher in RA. No significant difference was observed when end-diastolic velocity (EDV) of OA and CRA was compared between the groups. The resistivity index (RI) of OA and CRA was higher in RA. Perifoveal/subfoveal CT was lower in RA. Negative correlation was detected between the RI of OA and the perifoveal CT, and a positive correlation was detected between RI of CRA and CT.

Conclusions

Ocular hemodynamics is effected by RA and can exaggerate ocular complications of various vascular diseases such as diabetes mellitus, hypertension, retinal vascular occlusions.
Literature
1.
go back to reference Itty S, Pulido JS, Bakri SJ, Baratz KH, Matteson EL, Hodge DO (2008) Anti-cyclic citrullinated peptide, rheumatoid factor, and ocular symptoms typical of rheumatoid arthritis. Trans Am Ophthalmol Soc 106:75–81PubMedPubMedCentral Itty S, Pulido JS, Bakri SJ, Baratz KH, Matteson EL, Hodge DO (2008) Anti-cyclic citrullinated peptide, rheumatoid factor, and ocular symptoms typical of rheumatoid arthritis. Trans Am Ophthalmol Soc 106:75–81PubMedPubMedCentral
2.
go back to reference Alamanos Y, Voulgari PV, Drosos AA (2006) Incidence and prevalence of rheumatoid arthritis, based on the 1987 American college of rheumatology criteria: a systematic review. Semin Arthritis Rheum 36:182–188CrossRefPubMed Alamanos Y, Voulgari PV, Drosos AA (2006) Incidence and prevalence of rheumatoid arthritis, based on the 1987 American college of rheumatology criteria: a systematic review. Semin Arthritis Rheum 36:182–188CrossRefPubMed
4.
go back to reference Widdifield J, Paterson JM, Bernatsky S, Tu K, Tomlinson G, Kuriya B (2014) The epidemiology of rheumatoid arthritis in Ontario, Canada. Arthritis Rheum 66:786–793CrossRef Widdifield J, Paterson JM, Bernatsky S, Tu K, Tomlinson G, Kuriya B (2014) The epidemiology of rheumatoid arthritis in Ontario, Canada. Arthritis Rheum 66:786–793CrossRef
5.
go back to reference Turesson C, O’Fallon WM, Crowson CS, Gabriel SE, Matteson EL (2003) Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years. Ann Rheum Dis 62:722–727CrossRefPubMedCentralPubMed Turesson C, O’Fallon WM, Crowson CS, Gabriel SE, Matteson EL (2003) Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years. Ann Rheum Dis 62:722–727CrossRefPubMedCentralPubMed
6.
go back to reference Makol A, Crowson CS, Wetter DA, Sokumbi O, Matteson EL, Warrington KJ (2014) Vasculitis associated with rheumatoid arthritis: a case-control study. Rheumatology 53:890–899CrossRefPubMedCentralPubMed Makol A, Crowson CS, Wetter DA, Sokumbi O, Matteson EL, Warrington KJ (2014) Vasculitis associated with rheumatoid arthritis: a case-control study. Rheumatology 53:890–899CrossRefPubMedCentralPubMed
7.
go back to reference Zlatanovic G, Veselinovic D, Cekic S, Zivković M, Dorđević-Jocić J, Zlatanović M (2010) Ocular manifestation of rheumatoid arthritis-different forms and frequency. Bosn J Basic Med Sci. 10:323–327CrossRefPubMedCentralPubMed Zlatanovic G, Veselinovic D, Cekic S, Zivković M, Dorđević-Jocić J, Zlatanović M (2010) Ocular manifestation of rheumatoid arthritis-different forms and frequency. Bosn J Basic Med Sci. 10:323–327CrossRefPubMedCentralPubMed
8.
go back to reference Hurd ER, Snyder WB, Ziff M (1970) Choroidal nodules and retinal detachments in rheumatoid arthritis. Improvement with fall in immunoglobulin levels following prednisolone and cyclophosphamide therapy. Am J Med 48:273–278CrossRefPubMed Hurd ER, Snyder WB, Ziff M (1970) Choroidal nodules and retinal detachments in rheumatoid arthritis. Improvement with fall in immunoglobulin levels following prednisolone and cyclophosphamide therapy. Am J Med 48:273–278CrossRefPubMed
9.
go back to reference Matsuo T (2001) Multiple occlusive retinal arteritis in both eyes of a patient with rheumatoid arthritis. Jpn J Ophthalmol 45:662–664CrossRefPubMed Matsuo T (2001) Multiple occlusive retinal arteritis in both eyes of a patient with rheumatoid arthritis. Jpn J Ophthalmol 45:662–664CrossRefPubMed
10.
go back to reference Matsuo T, Masuda I, Matsuo N (1998) Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. Jpn J Ophthalmol 42:51–55CrossRefPubMed Matsuo T, Masuda I, Matsuo N (1998) Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. Jpn J Ophthalmol 42:51–55CrossRefPubMed
11.
go back to reference Giordano N, D’Ettorre M, Biasi G, Fioravanti A, Moretti L, Marcolongo R (1990) Retinal vasculitis in rheumatoid arthritis: an angiographic study. Clin Exp Rheumatol 8:121–125PubMed Giordano N, D’Ettorre M, Biasi G, Fioravanti A, Moretti L, Marcolongo R (1990) Retinal vasculitis in rheumatoid arthritis: an angiographic study. Clin Exp Rheumatol 8:121–125PubMed
12.
go back to reference Martin MF, Scott DG, Gilbert C, Dieppe PA, Easty DL (1981) Retinal vasculitis in rheumatoid arthritis. Br Med J (Clin Res Ed) 282:1745–1746CrossRef Martin MF, Scott DG, Gilbert C, Dieppe PA, Easty DL (1981) Retinal vasculitis in rheumatoid arthritis. Br Med J (Clin Res Ed) 282:1745–1746CrossRef
13.
go back to reference Duru N, Altinkaynak H, Erten S, Can ME, Duru Z, Uğurlu FG (2016) Thinning of choroidal thickness in patients with rheumatoid arthritis unrelated to disease activity. Ocul Immunol Inflamm 24:246–253CrossRefPubMed Duru N, Altinkaynak H, Erten S, Can ME, Duru Z, Uğurlu FG (2016) Thinning of choroidal thickness in patients with rheumatoid arthritis unrelated to disease activity. Ocul Immunol Inflamm 24:246–253CrossRefPubMed
14.
go back to reference Erdogmus B, Yazici S, Yazici B, Ataoglu S, Buyukkaya R, Yuksel H (2007) Orbital blood flow velocities in patients with rheumatoid arthritis. J Clin Ultrasound 35:367–371CrossRefPubMed Erdogmus B, Yazici S, Yazici B, Ataoglu S, Buyukkaya R, Yuksel H (2007) Orbital blood flow velocities in patients with rheumatoid arthritis. J Clin Ultrasound 35:367–371CrossRefPubMed
15.
go back to reference Spaide RF, Koizumi H, Pozonni MC (2008) Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 146:496–500CrossRefPubMed Spaide RF, Koizumi H, Pozonni MC (2008) Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 146:496–500CrossRefPubMed
16.
go back to reference Margolis R, Spaide RF (2009) A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol 147:811–815CrossRefPubMed Margolis R, Spaide RF (2009) A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol 147:811–815CrossRefPubMed
17.
go back to reference Hua R, Liu L, Lib C, Chen L (2014) Evaluation of the effects of photodynamic therapy on chronic central serous chorioretinopathy based on the mean choroidal thickness and the lumen area of abnormal choroidal vessels. Photodiagnosis Photodyn Ther 11:519–525CrossRefPubMed Hua R, Liu L, Lib C, Chen L (2014) Evaluation of the effects of photodynamic therapy on chronic central serous chorioretinopathy based on the mean choroidal thickness and the lumen area of abnormal choroidal vessels. Photodiagnosis Photodyn Ther 11:519–525CrossRefPubMed
18.
go back to reference Maruko I, Iida T, Sugano Y, Oyamada H, Sekiryu T, Fujiwara T (2011) Subfoveal choroidal thickness after treatment of Vogt–Koyanagi–Harada disease. Retina 31:510–517CrossRefPubMed Maruko I, Iida T, Sugano Y, Oyamada H, Sekiryu T, Fujiwara T (2011) Subfoveal choroidal thickness after treatment of Vogt–Koyanagi–Harada disease. Retina 31:510–517CrossRefPubMed
19.
go back to reference Ishikawa S, Taguchi M, Muraoka T, Sakurai Y, Kanda T, Takeuchi M (2014) Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Behçet’s disease. Br J Ophthalmol 98:1508–1513CrossRefPubMed Ishikawa S, Taguchi M, Muraoka T, Sakurai Y, Kanda T, Takeuchi M (2014) Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Behçet’s disease. Br J Ophthalmol 98:1508–1513CrossRefPubMed
20.
go back to reference Behdad B, Rahmani S, Montahaei T, Soheilian R, Soheilian M (2015) Enhanced depth imaging OCT (EDI-OCT) findings in acute phase of sympathetic ophthalmia. Int Ophthalmol 35:433–439CrossRefPubMed Behdad B, Rahmani S, Montahaei T, Soheilian R, Soheilian M (2015) Enhanced depth imaging OCT (EDI-OCT) findings in acute phase of sympathetic ophthalmia. Int Ophthalmol 35:433–439CrossRefPubMed
21.
22.
go back to reference Tranquart F, Berges O, Koskas P, Arsene S, Rossazza C, Pisella PJ (2003) Color Doppler imaging of orbital vessels: personal experience and literature review. J Clin Ultrasound 31:258–273CrossRefPubMed Tranquart F, Berges O, Koskas P, Arsene S, Rossazza C, Pisella PJ (2003) Color Doppler imaging of orbital vessels: personal experience and literature review. J Clin Ultrasound 31:258–273CrossRefPubMed
23.
go back to reference Matos KT, Arantes T, Souza AW, Ramos MH, Allemann N, Muccioli C (2014) Retinal angiography and colour Doppler of retrobulbar vessels in Takayasu arteritis. Can J Ophthalmol 49:80–86CrossRefPubMed Matos KT, Arantes T, Souza AW, Ramos MH, Allemann N, Muccioli C (2014) Retinal angiography and colour Doppler of retrobulbar vessels in Takayasu arteritis. Can J Ophthalmol 49:80–86CrossRefPubMed
24.
go back to reference Scott DG, Bacon PA, Tribe CR (1981) Systemic rheumatoid vasculitis: a clinical and laboratory study of 50 cases. Medicine (Baltimore) 60:288–297CrossRef Scott DG, Bacon PA, Tribe CR (1981) Systemic rheumatoid vasculitis: a clinical and laboratory study of 50 cases. Medicine (Baltimore) 60:288–297CrossRef
25.
go back to reference Koutkia P, Mylonakis E, Rounds S, Erickson A (2001) Leucocytoclastic vasculitis: an update for the clinician. Scand J Rheumatol 30:315–322CrossRefPubMed Koutkia P, Mylonakis E, Rounds S, Erickson A (2001) Leucocytoclastic vasculitis: an update for the clinician. Scand J Rheumatol 30:315–322CrossRefPubMed
27.
go back to reference Matsuo T, Koyama T, Morimoto N, Umezu H, Matsuo N (1990) Retinal vasculitis as a complication of rheumatoid arthritis. Ophthalmologica 201:196–200CrossRefPubMed Matsuo T, Koyama T, Morimoto N, Umezu H, Matsuo N (1990) Retinal vasculitis as a complication of rheumatoid arthritis. Ophthalmologica 201:196–200CrossRefPubMed
28.
go back to reference Androudi S, Dastiridou A, Symeonidis C, Kump L, Praidou A, Brazitikos P (2013) Retinal vasculitis in rheumatic diseases: an unseen burden. Clin Rheumatol 32:7–13CrossRefPubMed Androudi S, Dastiridou A, Symeonidis C, Kump L, Praidou A, Brazitikos P (2013) Retinal vasculitis in rheumatic diseases: an unseen burden. Clin Rheumatol 32:7–13CrossRefPubMed
29.
30.
go back to reference Laviers H, Zambarakji H (2014) Enhanced depth imaging-OCT of the choroid: a review of the current literature. Graefes Arch Clin Exp Ophthalmol 252:1871–1883CrossRefPubMed Laviers H, Zambarakji H (2014) Enhanced depth imaging-OCT of the choroid: a review of the current literature. Graefes Arch Clin Exp Ophthalmol 252:1871–1883CrossRefPubMed
31.
go back to reference Wei WB, Xu L, Jonas JB, Shao L, Chen CX, Zhou JQ (2013) Subfoveal choroidal thickness: the Beijing eye study. Ophthalmology 120:175–180CrossRefPubMed Wei WB, Xu L, Jonas JB, Shao L, Chen CX, Zhou JQ (2013) Subfoveal choroidal thickness: the Beijing eye study. Ophthalmology 120:175–180CrossRefPubMed
32.
go back to reference Somer D, Ozkan SB, Ozdemir H, Atilla S, Söylev MF, Duman S (2002) Colour Doppler imaging of superior ophthalmic vein in thyroid associated eye disease. Jpn J Ophthalmol 46:341–345CrossRefPubMed Somer D, Ozkan SB, Ozdemir H, Atilla S, Söylev MF, Duman S (2002) Colour Doppler imaging of superior ophthalmic vein in thyroid associated eye disease. Jpn J Ophthalmol 46:341–345CrossRefPubMed
33.
go back to reference Fitzgerald ME, Wildsoet CF, Reiner A (2002) Temporal relationship of choroidal blood flow and thickness changes during recovery from form deprivation myopia in chicks. Exp Eye Res 74:561–570CrossRefPubMed Fitzgerald ME, Wildsoet CF, Reiner A (2002) Temporal relationship of choroidal blood flow and thickness changes during recovery from form deprivation myopia in chicks. Exp Eye Res 74:561–570CrossRefPubMed
34.
go back to reference Reitsamer HA, Kiel JW (2002) A rabbit model to study orbital venous pressure, intraocular pressure, and ocular hemodynamics simultaneously. Invest Ophthalmol Vis Sci 43:3728–3734PubMed Reitsamer HA, Kiel JW (2002) A rabbit model to study orbital venous pressure, intraocular pressure, and ocular hemodynamics simultaneously. Invest Ophthalmol Vis Sci 43:3728–3734PubMed
35.
go back to reference Tetikoglu M, Temizturk F, Sagdik HM, Aktas S, Ozcura F, Ozkan Y, Temizturk S (2015) Evaluation of the choroid, fovea, and retinal nerve fiber layer in patients with rheumatoid arthritis. Ocul Immunol Inflamm 30:1–5 Tetikoglu M, Temizturk F, Sagdik HM, Aktas S, Ozcura F, Ozkan Y, Temizturk S (2015) Evaluation of the choroid, fovea, and retinal nerve fiber layer in patients with rheumatoid arthritis. Ocul Immunol Inflamm 30:1–5
36.
go back to reference Genta MS, Genta RM, Gabay C (2006) Systemic rheumatoid vasculitis: a review. Semin Arthritis Rheum 36:88–98CrossRefPubMed Genta MS, Genta RM, Gabay C (2006) Systemic rheumatoid vasculitis: a review. Semin Arthritis Rheum 36:88–98CrossRefPubMed
37.
go back to reference Vollertsen RS, Conn DL (1990) Vasculitis associated with rheumatoid arthritis. Rheum Dis Clin North Am 16:445–461PubMed Vollertsen RS, Conn DL (1990) Vasculitis associated with rheumatoid arthritis. Rheum Dis Clin North Am 16:445–461PubMed
38.
39.
go back to reference Tranquart F, Bergès O, Koskas P, Arsene S, Rossazza C, Pisella PJ (2003) Color Doppler imaging of orbital vessels: personal experience and literature review. J Clin Ultrasound 31:258–273CrossRefPubMed Tranquart F, Bergès O, Koskas P, Arsene S, Rossazza C, Pisella PJ (2003) Color Doppler imaging of orbital vessels: personal experience and literature review. J Clin Ultrasound 31:258–273CrossRefPubMed
40.
go back to reference Ozsahin M, Buyukkaya R, Besir FH, Onder HI, Erdogmus B, Ataoglu S, Güclü D, Kolukisa R (2015) Color Doppler imaging of the orbital vessels in ankylosing spondylitis. Semin Ophthalmol 30:360–363CrossRefPubMed Ozsahin M, Buyukkaya R, Besir FH, Onder HI, Erdogmus B, Ataoglu S, Güclü D, Kolukisa R (2015) Color Doppler imaging of the orbital vessels in ankylosing spondylitis. Semin Ophthalmol 30:360–363CrossRefPubMed
41.
go back to reference Oner A, Akal A, Erdogan N, Dogan H, Oner M (2006) Color Doppler imaging of ocular hemodynamic changes in Behçet disease and uveitis patients with different etiologies. Curr Eye Res 31:519–523CrossRefPubMed Oner A, Akal A, Erdogan N, Dogan H, Oner M (2006) Color Doppler imaging of ocular hemodynamic changes in Behçet disease and uveitis patients with different etiologies. Curr Eye Res 31:519–523CrossRefPubMed
42.
go back to reference Duranoğlu Y, Apaydin C, Karaali K, Yücel I, Apaydin A (2001) Color Doppler imaging of the orbital vessels in Behçet’s disease. Ophthalmologica 215:8–15CrossRefPubMed Duranoğlu Y, Apaydin C, Karaali K, Yücel I, Apaydin A (2001) Color Doppler imaging of the orbital vessels in Behçet’s disease. Ophthalmologica 215:8–15CrossRefPubMed
43.
go back to reference Isik C, Yagci B, Yildirim C, Yaylali V, Tatlipinar S, Ozden S (2007) Orbital color Doppler imaging in Behçet’s disease with or without ocular involvement. Int Ophthalmol 27:37–42CrossRefPubMed Isik C, Yagci B, Yildirim C, Yaylali V, Tatlipinar S, Ozden S (2007) Orbital color Doppler imaging in Behçet’s disease with or without ocular involvement. Int Ophthalmol 27:37–42CrossRefPubMed
Metadata
Title
Evaluation of retrobulbar blood flow and choroidal thickness in patients with rheumatoid arthritis
Authors
Ali Kal
Enes Duman
Almila Sarıgül Sezenöz
Mahmut Oğuz Ulusoy
Öznur Kal
Publication date
01-10-2018
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 5/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0656-6

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